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Fusion gene ID: 6932 |
FusionGeneSummary for CHAC1_C16orf72 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHAC1_C16orf72 | Fusion gene ID: 6932 | Hgene | Tgene | Gene symbol | CHAC1 | C16orf72 | Gene ID | 79094 | 29035 |
| Gene name | ChaC glutathione specific gamma-glutamylcyclotransferase 1 | chromosome 16 open reading frame 72 | |
| Synonyms | - | PRO0149 | |
| Cytomap | 15q15.1 | 16p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutathione-specific gamma-glutamylcyclotransferase 1ChaC, cation transport regulator homolog 1ChaC, cation transport regulator-like 1blocks Notch proteinbotchgamma-GCG 1gamma-GCT acting on glutathione homolog 1 | UPF0472 protein C16orf72 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9BUX1 | Q14CZ0 | |
| Ensembl transtripts involved in fusion gene | ENST00000444189, ENST00000446533, ENST00000487220, | ENST00000327827, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 1=16 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/16*10)=1.64385618977472 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CHAC1 [Title/Abstract] AND C16orf72 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA374390 | CHAC1 | chr15 | 41248361 | + | C16orf72 | chr16 | 9204863 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000444189 | ENST00000327827 | CHAC1 | chr15 | 41248361 | + | C16orf72 | chr16 | 9204863 | + |
| 3UTR-intron | ENST00000446533 | ENST00000327827 | CHAC1 | chr15 | 41248361 | + | C16orf72 | chr16 | 9204863 | + |
| 5CDS-intron | ENST00000487220 | ENST00000327827 | CHAC1 | chr15 | 41248361 | + | C16orf72 | chr16 | 9204863 | + |
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FusionProtFeatures for CHAC1_C16orf72 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHAC1 | C16orf72 |