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Fusion gene ID: 6927 |
FusionGeneSummary for CGNL1_HTN3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CGNL1_HTN3 | Fusion gene ID: 6927 | Hgene | Tgene | Gene symbol | CGNL1 | HTN3 | Gene ID | 84952 | 3347 |
| Gene name | cingulin like 1 | histatin 3 | |
| Synonyms | JACOP|PCING | HIS2|HTN2|HTN5 | |
| Cytomap | 15q21.3 | 4q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cingulin-like protein 1junction-associated coiled-coil proteinparacingulin | histatin-3PBbasic histidine-rich proteinhistatin-4histatin-5histatin-6histatin-7histatin-8histatin-9histidine-rich protein 3hst | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q0VF96 | P15516 | |
| Ensembl transtripts involved in fusion gene | ENST00000281282, ENST00000557813, | ENST00000526767, ENST00000530128, ENST00000381057, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 4 X 4 X 2=32 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CGNL1 [Title/Abstract] AND HTN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AK130503 | CGNL1 | chr15 | 57816385 | + | HTN3 | chr4 | 70894176 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000281282 | ENST00000526767 | CGNL1 | chr15 | 57816385 | + | HTN3 | chr4 | 70894176 | + |
| intron-5UTR | ENST00000281282 | ENST00000530128 | CGNL1 | chr15 | 57816385 | + | HTN3 | chr4 | 70894176 | + |
| intron-5UTR | ENST00000281282 | ENST00000381057 | CGNL1 | chr15 | 57816385 | + | HTN3 | chr4 | 70894176 | + |
| intron-5UTR | ENST00000557813 | ENST00000526767 | CGNL1 | chr15 | 57816385 | + | HTN3 | chr4 | 70894176 | + |
| intron-5UTR | ENST00000557813 | ENST00000530128 | CGNL1 | chr15 | 57816385 | + | HTN3 | chr4 | 70894176 | + |
| intron-5UTR | ENST00000557813 | ENST00000381057 | CGNL1 | chr15 | 57816385 | + | HTN3 | chr4 | 70894176 | + |
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FusionProtFeatures for CGNL1_HTN3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CGNL1 | HTN3 |