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Fusion gene ID: 6911

FusionGeneSummary for CFLAR_NDUFB3

Fusion gene summary

Fusion gene information	Fusion gene name: CFLAR_NDUFB3
	Fusion gene ID: 6911
		Hgene	Tgene
	Gene symbol	CFLAR	NDUFB3
	Gene ID	8837	4709
	Gene name	CASP8 and FADD like apoptosis regulator	NADH:ubiquinone oxidoreductase subunit B3
	Synonyms	CASH\|CASP8AP1\|CLARP\|Casper\|FLAME\|FLAME-1\|FLAME1\|FLIP\|I-FLICE\|MRIT\|c-FLIP\|c-FLIPL\|c-FLIPR\|c-FLIPS	B12\|CI-B12
	Cytomap	2q33.1	2q33.1
	Type of gene	protein-coding	protein-coding
	Description	CASP8 and FADD-like apoptosis regulatorFADD-like antiapoptotic molecule 1MACH-related inducer of toxicitycaspase homologcaspase-eight-related proteincaspase-like apoptosis regulatory proteincaspase-related inducer of apoptosiscellular FLICE-like in	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDaNADH-ubiquinone oxidoreductase B12 subunitcomplex I-B12
	Modification date	20180523	20180523
	UniProtAcc	O15519	O43676
	Ensembl transtripts involved in fusion gene	ENST00000309955, ENST00000443227, ENST00000341222, ENST00000340870, ENST00000355558, ENST00000341582, ENST00000342795, ENST00000395148, ENST00000423241, ENST00000490965, ENST00000440180, ENST00000457277, ENST00000494258, ENST00000479953,	ENST00000237889, ENST00000433898, ENST00000454214,
Fusion gene scores	* DoF score	3 X 5 X 4=60	2 X 2 X 3=12
	# samples	5	4
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CFLAR [Title/Abstract] AND NDUFB3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CFLAR	GO:0060544	regulation of necroptotic process	21737330
Hgene	CFLAR	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	26582200
Hgene	CFLAR	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	9208847

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	HNSC	TCGA-P3-A6T4-01A	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
TCGA	RV	UCS	TCGA-QN-A5NN-01A	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
TCGA	RV	UCS	TCGA-N5-A59E-01A	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000309955	ENST00000237889	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000309955	ENST00000433898	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000309955	ENST00000454214	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000443227	ENST00000237889	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000443227	ENST00000433898	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000443227	ENST00000454214	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000341222	ENST00000237889	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000341222	ENST00000433898	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000341222	ENST00000454214	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000340870	ENST00000237889	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000340870	ENST00000433898	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000340870	ENST00000454214	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000355558	ENST00000237889	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000355558	ENST00000433898	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000355558	ENST00000454214	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000341582	ENST00000237889	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000341582	ENST00000433898	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000341582	ENST00000454214	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000342795	ENST00000237889	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000342795	ENST00000433898	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000342795	ENST00000454214	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000395148	ENST00000237889	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000395148	ENST00000433898	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000395148	ENST00000454214	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000423241	ENST00000237889	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000423241	ENST00000433898	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000423241	ENST00000454214	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000490965	ENST00000237889	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000490965	ENST00000433898	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000490965	ENST00000454214	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000440180	ENST00000237889	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000440180	ENST00000433898	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000440180	ENST00000454214	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000457277	ENST00000237889	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000457277	ENST00000433898	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000457277	ENST00000454214	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000494258	ENST00000237889	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000494258	ENST00000433898	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000494258	ENST00000454214	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000479953	ENST00000237889	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000479953	ENST00000433898	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
In-frame	ENST00000479953	ENST00000454214	CFLAR	chr2	202005162	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000309955	ENST00000237889	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000309955	ENST00000433898	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000309955	ENST00000454214	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000443227	ENST00000237889	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000443227	ENST00000433898	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000443227	ENST00000454214	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000341222	ENST00000237889	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000341222	ENST00000433898	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000341222	ENST00000454214	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000340870	ENST00000237889	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000340870	ENST00000433898	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000340870	ENST00000454214	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000355558	ENST00000237889	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000355558	ENST00000433898	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000355558	ENST00000454214	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000341582	ENST00000237889	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000341582	ENST00000433898	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000341582	ENST00000454214	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000342795	ENST00000237889	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000342795	ENST00000433898	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000342795	ENST00000454214	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000395148	ENST00000237889	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000395148	ENST00000433898	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000395148	ENST00000454214	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000423241	ENST00000237889	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000423241	ENST00000433898	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000423241	ENST00000454214	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000490965	ENST00000237889	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000490965	ENST00000433898	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000490965	ENST00000454214	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000440180	ENST00000237889	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000440180	ENST00000433898	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000440180	ENST00000454214	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000457277	ENST00000237889	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000457277	ENST00000433898	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000457277	ENST00000454214	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000494258	ENST00000237889	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000494258	ENST00000433898	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000494258	ENST00000454214	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000479953	ENST00000237889	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000479953	ENST00000433898	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
Frame-shift	ENST00000479953	ENST00000454214	CFLAR	chr2	202014558	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000309955	ENST00000237889	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000309955	ENST00000433898	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000309955	ENST00000454214	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000443227	ENST00000237889	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000443227	ENST00000433898	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000443227	ENST00000454214	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000341222	ENST00000237889	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000341222	ENST00000433898	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000341222	ENST00000454214	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000340870	ENST00000237889	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000340870	ENST00000433898	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000340870	ENST00000454214	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000355558	ENST00000237889	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000355558	ENST00000433898	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000355558	ENST00000454214	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000341582	ENST00000237889	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000341582	ENST00000433898	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000341582	ENST00000454214	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000342795	ENST00000237889	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000342795	ENST00000433898	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000342795	ENST00000454214	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000395148	ENST00000237889	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000395148	ENST00000433898	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
5UTR-3CDS	ENST00000395148	ENST00000454214	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000423241	ENST00000237889	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000423241	ENST00000433898	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000423241	ENST00000454214	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000490965	ENST00000237889	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000490965	ENST00000433898	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000490965	ENST00000454214	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000440180	ENST00000237889	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000440180	ENST00000433898	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000440180	ENST00000454214	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000457277	ENST00000237889	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000457277	ENST00000433898	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000457277	ENST00000454214	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000494258	ENST00000237889	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000494258	ENST00000433898	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000494258	ENST00000454214	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000479953	ENST00000237889	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000479953	ENST00000433898	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+
intron-3CDS	ENST00000479953	ENST00000454214	CFLAR	chr2	201981204	+	NDUFB3	chr2	201950182	+

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FusionProtFeatures for CFLAR_NDUFB3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CFLAR O15519	NDUFB3 O43676

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Fusion gene ID: 6911

FusionGeneSummary for CFLAR_NDUFB3

FusionProtFeatures for CFLAR_NDUFB3