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Fusion gene ID: 6906 |
FusionGeneSummary for CFL1_TXNDC5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CFL1_TXNDC5 | Fusion gene ID: 6906 | Hgene | Tgene | Gene symbol | CFL1 | TXNDC5 | Gene ID | 6944 | 81567 |
| Gene name | vacuolar protein sorting 72 homolog | thioredoxin domain containing 5 | |
| Synonyms | CFL1|Swc2|TCFL1|YL-1|YL1 | ENDOPDI|ERP46|HCC-2|HCC2|PDIA15|STRF8|UNQ364 | |
| Cytomap | 1q21.3 | 6p24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vacuolar protein sorting-associated protein 72 homologtranscription factor-like 1transformation suppressor gene YL-1 | thioredoxin domain-containing protein 5ER protein 46endoplasmic reticulum protein ERp46endoplasmic reticulum resident protein 46endothelial protein disulphide isomeraseprotein disulfide isomerase family A, member 15thioredoxin domain containing 5 (e | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P23528 | Q8NBS9 | |
| Ensembl transtripts involved in fusion gene | ENST00000530157, ENST00000525451, ENST00000308162, ENST00000527344, ENST00000531407, ENST00000524553, ENST00000534769, ENST00000531413, | ENST00000539054, ENST00000379757, ENST00000473453, | |
| Fusion gene scores | * DoF score | 7 X 8 X 2=112 | 7 X 7 X 2=98 |
| # samples | 8 | 7 | |
| ** MAII score | log2(8/112*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CFL1 [Title/Abstract] AND TXNDC5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP358611 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000530157 | ENST00000539054 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000530157 | ENST00000379757 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000530157 | ENST00000473453 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000525451 | ENST00000539054 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000525451 | ENST00000379757 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000525451 | ENST00000473453 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000308162 | ENST00000539054 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000308162 | ENST00000379757 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000308162 | ENST00000473453 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000527344 | ENST00000539054 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000527344 | ENST00000379757 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000527344 | ENST00000473453 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000531407 | ENST00000539054 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000531407 | ENST00000379757 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000531407 | ENST00000473453 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000524553 | ENST00000539054 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000524553 | ENST00000379757 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000524553 | ENST00000473453 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000534769 | ENST00000539054 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000534769 | ENST00000379757 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000534769 | ENST00000473453 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000531413 | ENST00000539054 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000531413 | ENST00000379757 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
| intron-3CDS | ENST00000531413 | ENST00000473453 | CFL1 | chr11 | 65622881 | - | TXNDC5 | chr6 | 7883469 | - |
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FusionProtFeatures for CFL1_TXNDC5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CFL1 | TXNDC5 |