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Fusion gene ID: 6882 |
FusionGeneSummary for CES4A_AKT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CES4A_AKT2 | Fusion gene ID: 6882 | Hgene | Tgene | Gene symbol | CES4A | AKT2 | Gene ID | 283848 | 208 |
| Gene name | carboxylesterase 4A | AKT serine/threonine kinase 2 | |
| Synonyms | CES6|CES8 | HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA | |
| Cytomap | 16q22.1 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | carboxylesterase 4Acarboxylesterase 6carboxylesterase 8 (putative) | RAC-beta serine/threonine-protein kinasePKB betaRAC-PK-betamurine thymoma viral (v-akt) homolog-2protein kinase Akt-2protein kinase B betaputative v-akt murine thymoma viral oncoprotein 2rac protein kinase betav-akt murine thymoma viral oncogene h | |
| Modification date | 20180526 | 20180527 | |
| UniProtAcc | Q5XG92 | P31751 | |
| Ensembl transtripts involved in fusion gene | ENST00000540947, ENST00000338718, ENST00000541479, ENST00000398354, ENST00000326686, ENST00000540579, ENST00000535696, ENST00000397205, | ENST00000392038, ENST00000424901, ENST00000311278, ENST00000579047, ENST00000581582, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 7 X 5=280 |
| # samples | 1 | 8 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CES4A [Title/Abstract] AND AKT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | AKT2 | GO:0030335 | positive regulation of cell migration | 25428377 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF950673 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000540947 | ENST00000392038 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000540947 | ENST00000424901 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000540947 | ENST00000311278 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000540947 | ENST00000579047 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000540947 | ENST00000581582 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000338718 | ENST00000392038 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000338718 | ENST00000424901 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000338718 | ENST00000311278 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000338718 | ENST00000579047 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000338718 | ENST00000581582 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000541479 | ENST00000392038 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000541479 | ENST00000424901 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000541479 | ENST00000311278 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000541479 | ENST00000579047 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000541479 | ENST00000581582 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000398354 | ENST00000392038 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000398354 | ENST00000424901 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000398354 | ENST00000311278 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000398354 | ENST00000579047 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000398354 | ENST00000581582 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000326686 | ENST00000392038 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000326686 | ENST00000424901 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000326686 | ENST00000311278 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000326686 | ENST00000579047 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000326686 | ENST00000581582 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| intron-intron | ENST00000540579 | ENST00000392038 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| intron-intron | ENST00000540579 | ENST00000424901 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| intron-intron | ENST00000540579 | ENST00000311278 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| intron-intron | ENST00000540579 | ENST00000579047 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| intron-intron | ENST00000540579 | ENST00000581582 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| intron-intron | ENST00000535696 | ENST00000392038 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| intron-intron | ENST00000535696 | ENST00000424901 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| intron-intron | ENST00000535696 | ENST00000311278 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| intron-intron | ENST00000535696 | ENST00000579047 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| intron-intron | ENST00000535696 | ENST00000581582 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000397205 | ENST00000392038 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000397205 | ENST00000424901 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000397205 | ENST00000311278 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000397205 | ENST00000579047 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
| 3UTR-intron | ENST00000397205 | ENST00000581582 | CES4A | chr16 | 67043557 | + | AKT2 | chr19 | 40773373 | + |
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FusionProtFeatures for CES4A_AKT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CES4A | AKT2 |