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Fusion gene ID: 6754 |
FusionGeneSummary for CEL_CPA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CEL_CPA1 | Fusion gene ID: 6754 | Hgene | Tgene | Gene symbol | CEL | CPA1 | Gene ID | 1056 | 1357 |
| Gene name | carboxyl ester lipase | carboxypeptidase A1 | |
| Synonyms | BAL|BSDL|BSSL|CELL|CEase|FAP|FAPP|LIPA|MODY8 | CPA | |
| Cytomap | 9q34.13 | 7q32.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bile salt-activated lipasebile salt-dependent lipase, oncofetal isoformbucelipasecarboxyl ester hydrolasecarboxyl ester lipase (bile salt-stimulated lipase)cholesterol esterasefetoacinar pancreatic proteinlysophospholipase, pancreaticsterol estera | carboxypeptidase A1carboxypeptidase A1 (pancreatic)pancreatic carboxypeptidase A | |
| Modification date | 20180528 | 20180523 | |
| UniProtAcc | P19835 | P15085 | |
| Ensembl transtripts involved in fusion gene | ENST00000351304, ENST00000372080, | ENST00000011292, ENST00000484324, | |
| Fusion gene scores | * DoF score | 3 X 4 X 2=24 | 5 X 6 X 2=60 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CEL [Title/Abstract] AND CPA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CEL | GO:0006707 | cholesterol catabolic process | 12031288 |
| Hgene | CEL | GO:0030157 | pancreatic juice secretion | 1854805 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PAAD | TCGA-F2-6880-01A | CEL | chr9 | 135937455 | + | CPA1 | chr7 | 130027665 | + |
| TCGA | LD | PAAD | TCGA-IB-7652-01A | CEL | chr9 | 135940149 | + | CPA1 | chr7 | 130024987 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000351304 | ENST00000011292 | CEL | chr9 | 135937455 | + | CPA1 | chr7 | 130027665 | + |
| Frame-shift | ENST00000351304 | ENST00000484324 | CEL | chr9 | 135937455 | + | CPA1 | chr7 | 130027665 | + |
| Frame-shift | ENST00000372080 | ENST00000011292 | CEL | chr9 | 135937455 | + | CPA1 | chr7 | 130027665 | + |
| Frame-shift | ENST00000372080 | ENST00000484324 | CEL | chr9 | 135937455 | + | CPA1 | chr7 | 130027665 | + |
| In-frame | ENST00000351304 | ENST00000011292 | CEL | chr9 | 135940149 | + | CPA1 | chr7 | 130024987 | + |
| In-frame | ENST00000351304 | ENST00000484324 | CEL | chr9 | 135940149 | + | CPA1 | chr7 | 130024987 | + |
| In-frame | ENST00000372080 | ENST00000011292 | CEL | chr9 | 135940149 | + | CPA1 | chr7 | 130024987 | + |
| In-frame | ENST00000372080 | ENST00000484324 | CEL | chr9 | 135940149 | + | CPA1 | chr7 | 130024987 | + |
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FusionProtFeatures for CEL_CPA1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CEL | CPA1 |