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Fusion gene ID: 6716 |
FusionGeneSummary for CELF1_MYOM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CELF1_MYOM1 | Fusion gene ID: 6716 | Hgene | Tgene | Gene symbol | CELF1 | MYOM1 | Gene ID | 10658 | 8736 |
| Gene name | CUGBP Elav-like family member 1 | myomesin 1 | |
| Synonyms | BRUNOL2|CUG-BP|CUGBP|CUGBP1|EDEN-BP|NAB50|NAPOR|hNab50 | SKELEMIN | |
| Cytomap | 11p11.2 | 18p11.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CUGBP Elav-like family member 150 kDa nuclear polyadenylated RNA-binding proteinCELF-1CUG RNA-binding proteinCUG triplet repeat RNA-binding protein 1CUG-BP- and ETR-3-like factor 1CUG-BP1EDEN-BP homologRNA-binding protein BRUNOL-2bruno-like 2bru | myomesin-1190 kDa connectin-associated protein190 kDa titin-associated proteinEH-myomesinmyomesin (M-protein) 1 (190kD)myomesin 1 (skelemin) 185kDamyomesin 1 variant 1myomesin 1, 185kDamyomesin family member 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q92879 | P52179 | |
| Ensembl transtripts involved in fusion gene | ENST00000395290, ENST00000358597, ENST00000395292, ENST00000310513, ENST00000361904, ENST00000539455, ENST00000531165, ENST00000532048, | ENST00000400569, ENST00000356443, ENST00000261606, ENST00000582016, | |
| Fusion gene scores | * DoF score | 13 X 11 X 11=1573 | 5 X 5 X 5=125 |
| # samples | 18 | 7 | |
| ** MAII score | log2(18/1573*10)=-3.12744985908601 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/125*10)=-0.836501267717121 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CELF1 [Title/Abstract] AND MYOM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CELF1 | GO:0006376 | mRNA splice site selection | 11158314 |
| Hgene | CELF1 | GO:0043484 | regulation of RNA splicing | 16946708 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-55-1592-01A | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000395290 | ENST00000400569 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000395290 | ENST00000356443 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000395290 | ENST00000261606 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-intron | ENST00000395290 | ENST00000582016 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000358597 | ENST00000400569 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000358597 | ENST00000356443 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000358597 | ENST00000261606 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-intron | ENST00000358597 | ENST00000582016 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000395292 | ENST00000400569 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000395292 | ENST00000356443 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000395292 | ENST00000261606 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-intron | ENST00000395292 | ENST00000582016 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| 5UTR-3CDS | ENST00000310513 | ENST00000400569 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| 5UTR-3CDS | ENST00000310513 | ENST00000356443 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| 5UTR-3CDS | ENST00000310513 | ENST00000261606 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| 5UTR-intron | ENST00000310513 | ENST00000582016 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000361904 | ENST00000400569 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000361904 | ENST00000356443 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000361904 | ENST00000261606 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-intron | ENST00000361904 | ENST00000582016 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000539455 | ENST00000400569 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000539455 | ENST00000356443 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000539455 | ENST00000261606 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-intron | ENST00000539455 | ENST00000582016 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| 5UTR-3CDS | ENST00000531165 | ENST00000400569 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| 5UTR-3CDS | ENST00000531165 | ENST00000356443 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| 5UTR-3CDS | ENST00000531165 | ENST00000261606 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| 5UTR-intron | ENST00000531165 | ENST00000582016 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000532048 | ENST00000400569 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000532048 | ENST00000356443 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-3CDS | ENST00000532048 | ENST00000261606 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
| intron-intron | ENST00000532048 | ENST00000582016 | CELF1 | chr11 | 47574544 | - | MYOM1 | chr18 | 3131494 | - |
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FusionProtFeatures for CELF1_MYOM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CELF1 | MYOM1 |