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Fusion gene ID: 6672

FusionGeneSummary for CDS2_CRK

Fusion gene summary

Fusion gene information	Fusion gene name: CDS2_CRK
	Fusion gene ID: 6672
		Hgene	Tgene
	Gene symbol	CDS2	CRK
	Gene ID	8760	1398
	Gene name	CDP-diacylglycerol synthase 2	CRK proto-oncogene, adaptor protein
	Synonyms	-	CRKII\|p38
	Cytomap	20p12.3	17p13.3
	Type of gene	protein-coding	protein-coding
	Description	phosphatidate cytidylyltransferase 2CDP-DAG synthase 2CDP-DG synthase 2CDP-DG synthetase 2CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2CDP-diglyceride diphosphorylase 2CDP-diglyceride pyrophosphorylase 2CDP-diglyceride synthase	adapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like protein
	Modification date	20180523	20180522
	UniProtAcc	O95674	P46108
	Ensembl transtripts involved in fusion gene	ENST00000460006, ENST00000379062, ENST00000379070, ENST00000535100,	ENST00000398970, ENST00000300574, ENST00000574295, ENST00000572145,
Fusion gene scores	* DoF score	2 X 2 X 2=8	8 X 8 X 2=128
	# samples	2	8
	** MAII score	log2(2/8*10)=1.32192809488736	log2(8/128*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CDS2 [Title/Abstract] AND CRK [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CRK	GO:0009966	regulation of signal transduction	17515907
Tgene	CRK	GO:0032956	regulation of actin cytoskeleton organization	11870224
Tgene	CRK	GO:0043087	regulation of GTPase activity	11870224
Tgene	CRK	GO:0048013	ephrin receptor signaling pathway	11870224
Tgene	CRK	GO:0061045	negative regulation of wound healing	17515907
Tgene	CRK	GO:0071538	SH2 domain-mediated complex assembly	12384576
Tgene	CRK	GO:2000146	negative regulation of cell motility	17515907

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			DN999202	CDS2	chr20	5176289	+	CRK	chr17	1325788	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3UTR	ENST00000460006	ENST00000398970	CDS2	chr20	5176289	+	CRK	chr17	1325788	-
3UTR-3UTR	ENST00000460006	ENST00000300574	CDS2	chr20	5176289	+	CRK	chr17	1325788	-
3UTR-3UTR	ENST00000460006	ENST00000574295	CDS2	chr20	5176289	+	CRK	chr17	1325788	-
3UTR-intron	ENST00000460006	ENST00000572145	CDS2	chr20	5176289	+	CRK	chr17	1325788	-
intron-3UTR	ENST00000379062	ENST00000398970	CDS2	chr20	5176289	+	CRK	chr17	1325788	-
intron-3UTR	ENST00000379062	ENST00000300574	CDS2	chr20	5176289	+	CRK	chr17	1325788	-
intron-3UTR	ENST00000379062	ENST00000574295	CDS2	chr20	5176289	+	CRK	chr17	1325788	-
intron-intron	ENST00000379062	ENST00000572145	CDS2	chr20	5176289	+	CRK	chr17	1325788	-
intron-3UTR	ENST00000379070	ENST00000398970	CDS2	chr20	5176289	+	CRK	chr17	1325788	-
intron-3UTR	ENST00000379070	ENST00000300574	CDS2	chr20	5176289	+	CRK	chr17	1325788	-
intron-3UTR	ENST00000379070	ENST00000574295	CDS2	chr20	5176289	+	CRK	chr17	1325788	-
intron-intron	ENST00000379070	ENST00000572145	CDS2	chr20	5176289	+	CRK	chr17	1325788	-
intron-3UTR	ENST00000535100	ENST00000398970	CDS2	chr20	5176289	+	CRK	chr17	1325788	-
intron-3UTR	ENST00000535100	ENST00000300574	CDS2	chr20	5176289	+	CRK	chr17	1325788	-
intron-3UTR	ENST00000535100	ENST00000574295	CDS2	chr20	5176289	+	CRK	chr17	1325788	-
intron-intron	ENST00000535100	ENST00000572145	CDS2	chr20	5176289	+	CRK	chr17	1325788	-

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FusionProtFeatures for CDS2_CRK

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CDS2 O95674	CRK P46108

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Fusion gene ID: 6672

FusionGeneSummary for CDS2_CRK

FusionProtFeatures for CDS2_CRK