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Fusion gene ID: 6666 |
FusionGeneSummary for CDS1_UGT1A4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDS1_UGT1A4 | Fusion gene ID: 6666 | Hgene | Tgene | Gene symbol | CDS1 | UGT1A4 | Gene ID | 11200 | 54657 |
| Gene name | checkpoint kinase 2 | UDP glucuronosyltransferase family 1 member A4 | |
| Synonyms | CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53|hCds1 | HUG-BR2|UDPGT|UDPGT 1-4|UGT-1D|UGT1-04|UGT1.4|UGT1A4S|UGT1D | |
| Cytomap | 22q12.1 | 2q37.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase Chk2CHK2 checkpoint homologcds1 homologcheckpoint-like protein CHK2 | UDP-glucuronosyltransferase 1-4UDP glucuronosyltransferase 1 family, polypeptide A4UDP glycosyltransferase 1 family, polypeptide A4UDP-glucuronosyltransferase 1 family polypeptide A4sUDP-glucuronosyltransferase 1-DUDP-glucuronosyltransferase 1A4bili | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q92903 | P22310 | |
| Ensembl transtripts involved in fusion gene | ENST00000295887, | ENST00000373409, | |
| Fusion gene scores | * DoF score | 10 X 2 X 2=40 | 2 X 1 X 2=4 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/40*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: CDS1 [Title/Abstract] AND UGT1A4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDS1 | GO:0006355 | regulation of transcription, DNA-templated | 12717439 |
| Hgene | CDS1 | GO:0006468 | protein phosphorylation | 12717439 |
| Hgene | CDS1 | GO:0006974 | cellular response to DNA damage stimulus | 24550317 |
| Hgene | CDS1 | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | 12402044 |
| Hgene | CDS1 | GO:0042770 | signal transduction in response to DNA damage | 14744935 |
| Hgene | CDS1 | GO:0045893 | positive regulation of transcription, DNA-templated | 17101782 |
| Hgene | CDS1 | GO:0046777 | protein autophosphorylation | 16794575|18644861 |
| Hgene | CDS1 | GO:0050821 | protein stabilization | 12717439 |
| Tgene | UGT1A4 | GO:0052695 | cellular glucuronidation | 22579593 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-2F-A9KW-01A | CDS1 | chr4 | 85530678 | + | UGT1A4 | chr2 | 234675680 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000295887 | ENST00000373409 | CDS1 | chr4 | 85530678 | + | UGT1A4 | chr2 | 234675680 | + |
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FusionProtFeatures for CDS1_UGT1A4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDS1 | UGT1A4 |