|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 6620 |
FusionGeneSummary for CDKL2_CXCL11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDKL2_CXCL11 | Fusion gene ID: 6620 | Hgene | Tgene | Gene symbol | CDKL2 | CXCL11 | Gene ID | 8999 | 6373 |
| Gene name | cyclin dependent kinase like 2 | C-X-C motif chemokine ligand 11 | |
| Synonyms | KKIAMRE|P56 | H174|I-TAC|IP-9|IP9|SCYB11|SCYB9B|b-R1 | |
| Cytomap | 4q21.1 | 4q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclin-dependent kinase-like 2CDC2-related kinasep56 KKIAMRE protein kinaseprotein kinase p56 KKIAMREserine/threonine protein kinase KKIAMREtesticular tissue protein Li 35 | C-X-C motif chemokine 11beta-R1chemokine (C-X-C motif) ligand 11interferon gamma-inducible protein 9interferon-inducible T-cell alpha chemoattractantsmall inducible cytokine B11small inducible cytokine subfamily B (Cys-X-Cys), member 11small induci | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q92772 | O14625 | |
| Ensembl transtripts involved in fusion gene | ENST00000429927, ENST00000307465, | ENST00000306621, ENST00000503860, | |
| Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 4 X 1 X 4=16 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CDKL2 [Title/Abstract] AND CXCL11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CXCL11 | GO:0006935 | chemotaxis | 12782716 |
| Tgene | CXCL11 | GO:0030816 | positive regulation of cAMP metabolic process | 12782716 |
| Tgene | CXCL11 | GO:0043950 | positive regulation of cAMP-mediated signaling | 12782716 |
| Tgene | CXCL11 | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 12782716 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-55-7914-01A | CDKL2 | chr4 | 76551005 | - | CXCL11 | chr4 | 76957217 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000429927 | ENST00000306621 | CDKL2 | chr4 | 76551005 | - | CXCL11 | chr4 | 76957217 | - |
| 5CDS-5UTR | ENST00000429927 | ENST00000503860 | CDKL2 | chr4 | 76551005 | - | CXCL11 | chr4 | 76957217 | - |
| 5CDS-5UTR | ENST00000307465 | ENST00000306621 | CDKL2 | chr4 | 76551005 | - | CXCL11 | chr4 | 76957217 | - |
| 5CDS-5UTR | ENST00000307465 | ENST00000503860 | CDKL2 | chr4 | 76551005 | - | CXCL11 | chr4 | 76957217 | - |
Top |
FusionProtFeatures for CDKL2_CXCL11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDKL2 | CXCL11 |