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Fusion gene ID: 6590 |
FusionGeneSummary for CDK8_GCNT7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDK8_GCNT7 | Fusion gene ID: 6590 | Hgene | Tgene | Gene symbol | CDK8 | GCNT7 | Gene ID | 1024 | 140687 |
| Gene name | cyclin dependent kinase 8 | glucosaminyl (N-acetyl) transferase family member 7 | |
| Synonyms | K35 | C20orf105|dJ1153D9.2|gcnt | |
| Cytomap | 13q12.13 | 20q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclin-dependent kinase 8CDK8 protein kinasecell division protein kinase 8mediator complex subunit CDK8mediator of RNA polymerase II transcription subunit CDK8protein kinase K35 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7beta 1,6-N-acetylglucosaminyltransferase | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | P49336 | Q6ZNI0 | |
| Ensembl transtripts involved in fusion gene | ENST00000381527, ENST00000536792, ENST00000480323, | ENST00000243913, | |
| Fusion gene scores | * DoF score | 6 X 3 X 6=108 | 2 X 2 X 2=8 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CDK8 [Title/Abstract] AND GCNT7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-SI-AA8B-01A | CDK8 | chr13 | 26928017 | + | GCNT7 | chr20 | 55070353 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000381527 | ENST00000243913 | CDK8 | chr13 | 26928017 | + | GCNT7 | chr20 | 55070353 | - |
| Frame-shift | ENST00000536792 | ENST00000243913 | CDK8 | chr13 | 26928017 | + | GCNT7 | chr20 | 55070353 | - |
| intron-3CDS | ENST00000480323 | ENST00000243913 | CDK8 | chr13 | 26928017 | + | GCNT7 | chr20 | 55070353 | - |
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FusionProtFeatures for CDK8_GCNT7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDK8 | GCNT7 |