	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 6538

FusionGeneSummary for CDK19_USP14

Fusion gene summary

Fusion gene information	Fusion gene name: CDK19_USP14
	Fusion gene ID: 6538
		Hgene	Tgene
	Gene symbol	CDK19	USP14
	Gene ID	23097	9097
	Gene name	cyclin dependent kinase 19	ubiquitin specific peptidase 14
	Synonyms	CDC2L6\|CDK11\|bA346C16.3	TGT
	Cytomap	6q21	18p11.32
	Type of gene	protein-coding	protein-coding
	Description	cyclin-dependent kinase 19CDC2-related protein kinase 6CDK8-like cyclin-dependent kinasecell division cycle 2-like 6 (CDK8-like)cell division cycle 2-like protein kinase 6cell division protein kinase 19cyclin dependent kinase 19 variant 2cyclin-dep	ubiquitin carboxyl-terminal hydrolase 14deubiquitinating enzyme 14tRNA-guanine transglycosylase, 60-kD subunitubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)ubiquitin specific protease 14 (tRNA-guanine transglycosylase)ubiquitin thioe
	Modification date	20180523	20180523
	UniProtAcc	Q9BWU1	P54578
	Ensembl transtripts involved in fusion gene	ENST00000368911, ENST00000323817, ENST00000413605, ENST00000497709,	ENST00000582707, ENST00000400266, ENST00000383589, ENST00000261601,
Fusion gene scores	* DoF score	7 X 6 X 6=252	1 X 1 X 1=1
	# samples	9	1
	** MAII score	log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: CDK19 [Title/Abstract] AND USP14 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	USP14	GO:0016579	protein deubiquitination	23958854

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AI207519	CDK19	chr6	110974176	+	USP14	chr18	211368	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000368911	ENST00000582707	CDK19	chr6	110974176	+	USP14	chr18	211368	+
intron-intron	ENST00000368911	ENST00000400266	CDK19	chr6	110974176	+	USP14	chr18	211368	+
intron-3UTR	ENST00000368911	ENST00000383589	CDK19	chr6	110974176	+	USP14	chr18	211368	+
intron-3UTR	ENST00000368911	ENST00000261601	CDK19	chr6	110974176	+	USP14	chr18	211368	+
intron-3UTR	ENST00000323817	ENST00000582707	CDK19	chr6	110974176	+	USP14	chr18	211368	+
intron-intron	ENST00000323817	ENST00000400266	CDK19	chr6	110974176	+	USP14	chr18	211368	+
intron-3UTR	ENST00000323817	ENST00000383589	CDK19	chr6	110974176	+	USP14	chr18	211368	+
intron-3UTR	ENST00000323817	ENST00000261601	CDK19	chr6	110974176	+	USP14	chr18	211368	+
intron-3UTR	ENST00000413605	ENST00000582707	CDK19	chr6	110974176	+	USP14	chr18	211368	+
intron-intron	ENST00000413605	ENST00000400266	CDK19	chr6	110974176	+	USP14	chr18	211368	+
intron-3UTR	ENST00000413605	ENST00000383589	CDK19	chr6	110974176	+	USP14	chr18	211368	+
intron-3UTR	ENST00000413605	ENST00000261601	CDK19	chr6	110974176	+	USP14	chr18	211368	+
intron-3UTR	ENST00000497709	ENST00000582707	CDK19	chr6	110974176	+	USP14	chr18	211368	+
intron-intron	ENST00000497709	ENST00000400266	CDK19	chr6	110974176	+	USP14	chr18	211368	+
intron-3UTR	ENST00000497709	ENST00000383589	CDK19	chr6	110974176	+	USP14	chr18	211368	+
intron-3UTR	ENST00000497709	ENST00000261601	CDK19	chr6	110974176	+	USP14	chr18	211368	+

Top

FusionProtFeatures for CDK19_USP14

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CDK19 Q9BWU1	USP14 P54578

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 6538

FusionGeneSummary for CDK19_USP14

FusionProtFeatures for CDK19_USP14