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Fusion gene ID: 6528 |
FusionGeneSummary for CDK16_TIMP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDK16_TIMP1 | Fusion gene ID: 6528 | Hgene | Tgene | Gene symbol | CDK16 | TIMP1 | Gene ID | 5127 | 7076 |
| Gene name | cyclin dependent kinase 16 | TIMP metallopeptidase inhibitor 1 | |
| Synonyms | PCTAIRE|PCTAIRE1|PCTGAIRE|PCTK1 | CLGI|EPA|EPO|HCI|TIMP|TIMP-1 | |
| Cytomap | Xp11.3 | Xp11.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclin-dependent kinase 16PCTAIRE-motif protein kinase 1cell division protein kinase 16serine/threonine-protein kinase PCTAIRE-1testis secretory sperm-binding protein Li 224n | metalloproteinase inhibitor 1collagenase inhibitorerythroid potentiating activityfibroblast collagenase inhibitortissue inhibitor of metalloproteinases 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q00536 | P01033 | |
| Ensembl transtripts involved in fusion gene | ENST00000517997, ENST00000457458, ENST00000357227, ENST00000518022, ENST00000276052, | ENST00000218388, ENST00000377018, ENST00000456754, ENST00000377017, | |
| Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CDK16 [Title/Abstract] AND TIMP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TIMP1 | GO:0008284 | positive regulation of cell proliferation | 3839290 |
| Tgene | TIMP1 | GO:0010951 | negative regulation of endopeptidase activity | 3903517 |
| Tgene | TIMP1 | GO:0043086 | negative regulation of catalytic activity | 3903517 |
| Tgene | TIMP1 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis | 12714508 |
| Tgene | TIMP1 | GO:1905049 | negative regulation of metallopeptidase activity | 9573338 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCS | TCGA-N5-A4RD-01A | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000517997 | ENST00000218388 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| intron-5UTR | ENST00000517997 | ENST00000377018 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| intron-5UTR | ENST00000517997 | ENST00000456754 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| intron-5UTR | ENST00000517997 | ENST00000377017 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| intron-3CDS | ENST00000457458 | ENST00000218388 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| intron-5UTR | ENST00000457458 | ENST00000377018 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| intron-5UTR | ENST00000457458 | ENST00000456754 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| intron-5UTR | ENST00000457458 | ENST00000377017 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| 5UTR-3CDS | ENST00000357227 | ENST00000218388 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| 5UTR-5UTR | ENST00000357227 | ENST00000377018 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| 5UTR-5UTR | ENST00000357227 | ENST00000456754 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| 5UTR-5UTR | ENST00000357227 | ENST00000377017 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| intron-3CDS | ENST00000518022 | ENST00000218388 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| intron-5UTR | ENST00000518022 | ENST00000377018 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| intron-5UTR | ENST00000518022 | ENST00000456754 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| intron-5UTR | ENST00000518022 | ENST00000377017 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| intron-3CDS | ENST00000276052 | ENST00000218388 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| intron-5UTR | ENST00000276052 | ENST00000377018 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| intron-5UTR | ENST00000276052 | ENST00000456754 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
| intron-5UTR | ENST00000276052 | ENST00000377017 | CDK16 | chrX | 47078504 | + | TIMP1 | chrX | 47444604 | + |
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FusionProtFeatures for CDK16_TIMP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDK16 | TIMP1 |