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Fusion gene ID: 6506

FusionGeneSummary for CDK13_CLDN12

Fusion gene summary

Fusion gene information	Fusion gene name: CDK13_CLDN12
	Fusion gene ID: 6506
		Hgene	Tgene
	Gene symbol	CDK13	CLDN12
	Gene ID	8621	9069
	Gene name	cyclin dependent kinase 13	claudin 12
	Synonyms	CDC2L\|CDC2L5\|CHDFIDD\|CHED\|hCDK13	-
	Cytomap	7p14.1	7q21.13
	Type of gene	protein-coding	protein-coding
	Description	cyclin-dependent kinase 13CDC2-related protein kinase 5cell division cycle 2-like protein kinase 5cell division protein kinase 13cholinesterase-related cell division controller	claudin-12
	Modification date	20180523	20180519
	UniProtAcc	Q14004	P56749
	Ensembl transtripts involved in fusion gene	ENST00000181839, ENST00000340829, ENST00000484589,	ENST00000287916, ENST00000535571, ENST00000394605, ENST00000478752,
Fusion gene scores	* DoF score	11 X 9 X 11=1089	1 X 1 X 1=1
	# samples	16	1
	** MAII score	log2(16/1089*10)=-2.76686014382954 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: CDK13 [Title/Abstract] AND CLDN12 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CDK13	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	20952539

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-A2-A0CO-01A	CDK13	chr7	40102699	+	CLDN12	chr7	90034833	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000181839	ENST00000287916	CDK13	chr7	40102699	+	CLDN12	chr7	90034833	+
5CDS-intron	ENST00000181839	ENST00000535571	CDK13	chr7	40102699	+	CLDN12	chr7	90034833	+
5CDS-5UTR	ENST00000181839	ENST00000394605	CDK13	chr7	40102699	+	CLDN12	chr7	90034833	+
5CDS-intron	ENST00000181839	ENST00000478752	CDK13	chr7	40102699	+	CLDN12	chr7	90034833	+
5CDS-5UTR	ENST00000340829	ENST00000287916	CDK13	chr7	40102699	+	CLDN12	chr7	90034833	+
5CDS-intron	ENST00000340829	ENST00000535571	CDK13	chr7	40102699	+	CLDN12	chr7	90034833	+
5CDS-5UTR	ENST00000340829	ENST00000394605	CDK13	chr7	40102699	+	CLDN12	chr7	90034833	+
5CDS-intron	ENST00000340829	ENST00000478752	CDK13	chr7	40102699	+	CLDN12	chr7	90034833	+
3UTR-5UTR	ENST00000484589	ENST00000287916	CDK13	chr7	40102699	+	CLDN12	chr7	90034833	+
3UTR-intron	ENST00000484589	ENST00000535571	CDK13	chr7	40102699	+	CLDN12	chr7	90034833	+
3UTR-5UTR	ENST00000484589	ENST00000394605	CDK13	chr7	40102699	+	CLDN12	chr7	90034833	+
3UTR-intron	ENST00000484589	ENST00000478752	CDK13	chr7	40102699	+	CLDN12	chr7	90034833	+

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FusionProtFeatures for CDK13_CLDN12

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CDK13 Q14004	CLDN12 P56749

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Fusion gene ID: 6506

FusionGeneSummary for CDK13_CLDN12

FusionProtFeatures for CDK13_CLDN12