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Fusion gene ID: 6440 |
FusionGeneSummary for CDH1_CDH1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDH1_CDH1 | Fusion gene ID: 6440 | Hgene | Tgene | Gene symbol | CDH1 | CDH1 | Gene ID | 51343 | 51343 |
| Gene name | fizzy and cell division cycle 20 related 1 | fizzy and cell division cycle 20 related 1 | |
| Synonyms | CDC20C|CDH1|FZR|FZR2|HCDH|HCDH1 | CDC20C|CDH1|FZR|FZR2|HCDH|HCDH1 | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fizzy-related protein homologCDC20 homolog 1CDC20-like 1bCDC20-like protein 1cdh1/Hct1 homologfizzy/cell division cycle 20 related 1 | fizzy-related protein homologCDC20 homolog 1CDC20-like 1bCDC20-like protein 1cdh1/Hct1 homologfizzy/cell division cycle 20 related 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P12830 | P12830 | |
| Ensembl transtripts involved in fusion gene | ENST00000261769, ENST00000422392, ENST00000562836, | ENST00000261769, ENST00000422392, ENST00000562836, | |
| Fusion gene scores | * DoF score | 11 X 10 X 4=440 | 9 X 10 X 3=270 |
| # samples | 13 | 12 | |
| ** MAII score | log2(13/440*10)=-1.7589919004962 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/270*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CDH1 [Title/Abstract] AND CDH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDH1 | GO:0031145 | anaphase-promoting complex-dependent catabolic process | 18662541|21596315 |
| Hgene | CDH1 | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint | 18662541 |
| Hgene | CDH1 | GO:1904668 | positive regulation of ubiquitin protein ligase activity | 11459826 |
| Tgene | CDH1 | GO:0031145 | anaphase-promoting complex-dependent catabolic process | 18662541|21596315 |
| Tgene | CDH1 | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint | 18662541 |
| Tgene | CDH1 | GO:1904668 | positive regulation of ubiquitin protein ligase activity | 11459826 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF771649 | CDH1 | chr16 | 68868453 | - | CDH1 | chr16 | 68868806 | + | ||
| ChiTaRS3.1 | AW843356 | CDH1 | chr16 | 68868970 | + | CDH1 | chr16 | 68868933 | - | ||
| ChiTaRS3.1 | BF155173 | CDH1 | chr16 | 68847242 | - | CDH1 | chr16 | 68844170 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000261769 | ENST00000261769 | CDH1 | chr16 | 68868453 | - | CDH1 | chr16 | 68868806 | + |
| 3UTR-intron | ENST00000261769 | ENST00000422392 | CDH1 | chr16 | 68868453 | - | CDH1 | chr16 | 68868806 | + |
| 3UTR-intron | ENST00000261769 | ENST00000562836 | CDH1 | chr16 | 68868453 | - | CDH1 | chr16 | 68868806 | + |
| intron-3UTR | ENST00000422392 | ENST00000261769 | CDH1 | chr16 | 68868453 | - | CDH1 | chr16 | 68868806 | + |
| intron-intron | ENST00000422392 | ENST00000422392 | CDH1 | chr16 | 68868453 | - | CDH1 | chr16 | 68868806 | + |
| intron-intron | ENST00000422392 | ENST00000562836 | CDH1 | chr16 | 68868453 | - | CDH1 | chr16 | 68868806 | + |
| intron-3UTR | ENST00000562836 | ENST00000261769 | CDH1 | chr16 | 68868453 | - | CDH1 | chr16 | 68868806 | + |
| intron-intron | ENST00000562836 | ENST00000422392 | CDH1 | chr16 | 68868453 | - | CDH1 | chr16 | 68868806 | + |
| intron-intron | ENST00000562836 | ENST00000562836 | CDH1 | chr16 | 68868453 | - | CDH1 | chr16 | 68868806 | + |
| 3UTR-3UTR | ENST00000261769 | ENST00000261769 | CDH1 | chr16 | 68868970 | + | CDH1 | chr16 | 68868933 | - |
| 3UTR-intron | ENST00000261769 | ENST00000422392 | CDH1 | chr16 | 68868970 | + | CDH1 | chr16 | 68868933 | - |
| 3UTR-intron | ENST00000261769 | ENST00000562836 | CDH1 | chr16 | 68868970 | + | CDH1 | chr16 | 68868933 | - |
| intron-3UTR | ENST00000422392 | ENST00000261769 | CDH1 | chr16 | 68868970 | + | CDH1 | chr16 | 68868933 | - |
| intron-intron | ENST00000422392 | ENST00000422392 | CDH1 | chr16 | 68868970 | + | CDH1 | chr16 | 68868933 | - |
| intron-intron | ENST00000422392 | ENST00000562836 | CDH1 | chr16 | 68868970 | + | CDH1 | chr16 | 68868933 | - |
| intron-3UTR | ENST00000562836 | ENST00000261769 | CDH1 | chr16 | 68868970 | + | CDH1 | chr16 | 68868933 | - |
| intron-intron | ENST00000562836 | ENST00000422392 | CDH1 | chr16 | 68868970 | + | CDH1 | chr16 | 68868933 | - |
| intron-intron | ENST00000562836 | ENST00000562836 | CDH1 | chr16 | 68868970 | + | CDH1 | chr16 | 68868933 | - |
| In-frame | ENST00000261769 | ENST00000261769 | CDH1 | chr16 | 68847242 | - | CDH1 | chr16 | 68844170 | + |
| In-frame | ENST00000261769 | ENST00000422392 | CDH1 | chr16 | 68847242 | - | CDH1 | chr16 | 68844170 | + |
| 5CDS-3UTR | ENST00000261769 | ENST00000562836 | CDH1 | chr16 | 68847242 | - | CDH1 | chr16 | 68844170 | + |
| intron-3CDS | ENST00000422392 | ENST00000261769 | CDH1 | chr16 | 68847242 | - | CDH1 | chr16 | 68844170 | + |
| intron-3CDS | ENST00000422392 | ENST00000422392 | CDH1 | chr16 | 68847242 | - | CDH1 | chr16 | 68844170 | + |
| intron-3UTR | ENST00000422392 | ENST00000562836 | CDH1 | chr16 | 68847242 | - | CDH1 | chr16 | 68844170 | + |
| 3UTR-3CDS | ENST00000562836 | ENST00000261769 | CDH1 | chr16 | 68847242 | - | CDH1 | chr16 | 68844170 | + |
| 3UTR-3CDS | ENST00000562836 | ENST00000422392 | CDH1 | chr16 | 68847242 | - | CDH1 | chr16 | 68844170 | + |
| 3UTR-3UTR | ENST00000562836 | ENST00000562836 | CDH1 | chr16 | 68847242 | - | CDH1 | chr16 | 68844170 | + |
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FusionProtFeatures for CDH1_CDH1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDH1 | CDH1 |