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Fusion gene ID: 6430 |
FusionGeneSummary for CDH13_WFDC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDH13_WFDC1 | Fusion gene ID: 6430 | Hgene | Tgene | Gene symbol | CDH13 | WFDC1 | Gene ID | 1012 | 58189 |
| Gene name | cadherin 13 | WAP four-disulfide core domain 1 | |
| Synonyms | CDHH|P105 | PS20 | |
| Cytomap | 16q23.3 | 16q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cadherin-13H-cadherin (heart)T-cadT-cadherincadherin 13, H-cadherin (heart)heart cadherin | WAP four-disulfide core domain protein 1WAP four-disulfide core domain 1 homologprostate stromal protein ps20ps20 growth inhibitor | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P55290 | Q9HC57 | |
| Ensembl transtripts involved in fusion gene | ENST00000566620, ENST00000268613, ENST00000565636, ENST00000431540, ENST00000428848, ENST00000567445, ENST00000446376, ENST00000569454, | ENST00000219454, ENST00000568638, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 1 X 2=4 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: CDH13 [Title/Abstract] AND WFDC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDH13 | GO:0002040 | sprouting angiogenesis | 16873731 |
| Hgene | CDH13 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 10601632 |
| Hgene | CDH13 | GO:0007162 | negative regulation of cell adhesion | 14729458 |
| Hgene | CDH13 | GO:0008285 | negative regulation of cell proliferation | 10737605 |
| Hgene | CDH13 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | 10601632 |
| Hgene | CDH13 | GO:0030032 | lamellipodium assembly | 15703273 |
| Hgene | CDH13 | GO:0030335 | positive regulation of cell migration | 14729458 |
| Hgene | CDH13 | GO:0043542 | endothelial cell migration | 14729458 |
| Hgene | CDH13 | GO:0043616 | keratinocyte proliferation | 15816843 |
| Hgene | CDH13 | GO:0050850 | positive regulation of calcium-mediated signaling | 16013438 |
| Hgene | CDH13 | GO:0050927 | positive regulation of positive chemotaxis | 16013438 |
| Hgene | CDH13 | GO:0055096 | low-density lipoprotein particle mediated signaling | 16013438 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-JY-A6FA-01A | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000566620 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| Frame-shift | ENST00000566620 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| Frame-shift | ENST00000268613 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| Frame-shift | ENST00000268613 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| intron-3CDS | ENST00000565636 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| intron-3CDS | ENST00000565636 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| intron-3CDS | ENST00000431540 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| intron-3CDS | ENST00000431540 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| Frame-shift | ENST00000428848 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| Frame-shift | ENST00000428848 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| intron-3CDS | ENST00000567445 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| intron-3CDS | ENST00000567445 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| intron-3CDS | ENST00000446376 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| intron-3CDS | ENST00000446376 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| In-frame | ENST00000569454 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
| In-frame | ENST00000569454 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
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FusionProtFeatures for CDH13_WFDC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDH13 | WFDC1 |