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Fusion gene ID: 6422 |
FusionGeneSummary for CDH11_KIFC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDH11_KIFC3 | Fusion gene ID: 6422 | Hgene | Tgene | Gene symbol | CDH11 | KIFC3 | Gene ID | 1009 | 3801 |
| Gene name | cadherin 11 | kinesin family member C3 | |
| Synonyms | CAD11|CDHOB|ESWS|OB|OSF-4 | - | |
| Cytomap | 16q21 | 16q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cadherin-11cadherin 11, type 2, OB-cadherin (osteoblast) | kinesin-like protein KIFC3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P55287 | Q9BVG8 | |
| Ensembl transtripts involved in fusion gene | ENST00000394156, ENST00000268603, ENST00000566827, ENST00000569624, | ENST00000465878, ENST00000379655, ENST00000445690, ENST00000421376, ENST00000541240, ENST00000540079, ENST00000543930, ENST00000562903, ENST00000539578, ENST00000566975, | |
| Fusion gene scores | * DoF score | 4 X 6 X 3=72 | 6 X 6 X 3=108 |
| # samples | 8 | 5 | |
| ** MAII score | log2(8/72*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/108*10)=-1.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CDH11 [Title/Abstract] AND KIFC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-EE-A2MN-06A | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394156 | ENST00000465878 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| In-frame | ENST00000394156 | ENST00000379655 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| In-frame | ENST00000394156 | ENST00000445690 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| In-frame | ENST00000394156 | ENST00000421376 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| In-frame | ENST00000394156 | ENST00000541240 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| In-frame | ENST00000394156 | ENST00000540079 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| In-frame | ENST00000394156 | ENST00000543930 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| In-frame | ENST00000394156 | ENST00000562903 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| In-frame | ENST00000394156 | ENST00000539578 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| 5CDS-intron | ENST00000394156 | ENST00000566975 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000268603 | ENST00000465878 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000268603 | ENST00000379655 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000268603 | ENST00000445690 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000268603 | ENST00000421376 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000268603 | ENST00000541240 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000268603 | ENST00000540079 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000268603 | ENST00000543930 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000268603 | ENST00000562903 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000268603 | ENST00000539578 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-intron | ENST00000268603 | ENST00000566975 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000566827 | ENST00000465878 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000566827 | ENST00000379655 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000566827 | ENST00000445690 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000566827 | ENST00000421376 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000566827 | ENST00000541240 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000566827 | ENST00000540079 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000566827 | ENST00000543930 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000566827 | ENST00000562903 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000566827 | ENST00000539578 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-intron | ENST00000566827 | ENST00000566975 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000569624 | ENST00000465878 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000569624 | ENST00000379655 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000569624 | ENST00000445690 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000569624 | ENST00000421376 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000569624 | ENST00000541240 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000569624 | ENST00000540079 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000569624 | ENST00000543930 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000569624 | ENST00000562903 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-3CDS | ENST00000569624 | ENST00000539578 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
| intron-intron | ENST00000569624 | ENST00000566975 | CDH11 | chr16 | 64982512 | - | KIFC3 | chr16 | 57795448 | - |
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FusionProtFeatures for CDH11_KIFC3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDH11 | KIFC3 |