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Fusion gene ID: 6416 |
FusionGeneSummary for CDCA7L_PASD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDCA7L_PASD1 | Fusion gene ID: 6416 | Hgene | Tgene | Gene symbol | CDCA7L | PASD1 | Gene ID | 55536 | 139135 |
| Gene name | cell division cycle associated 7 like | PAS domain containing repressor 1 | |
| Synonyms | JPO2|R1|RAM2 | CT63|CT64|OXTES1 | |
| Cytomap | 7p15.3 | Xq28 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cell division cycle-associated 7-like proteintranscription factor RAM2 | circadian clock protein PASD1PAS domain containing 1cancer/testis antigen 63 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q96GN5 | Q8IV76 | |
| Ensembl transtripts involved in fusion gene | ENST00000356195, ENST00000406877, ENST00000373934, ENST00000465490, | ENST00000370357, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 2 X 3=18 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CDCA7L [Title/Abstract] AND PASD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDCA7L | GO:0008284 | positive regulation of cell proliferation | 15994933 |
| Tgene | PASD1 | GO:0042754 | negative regulation of circadian rhythm | 25936801 |
| Tgene | PASD1 | GO:0045892 | negative regulation of transcription, DNA-templated | 25936801 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | MESO | TCGA-ZN-A9VP-01A | CDCA7L | chr7 | 21956372 | - | PASD1 | chrX | 150828185 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000356195 | ENST00000370357 | CDCA7L | chr7 | 21956372 | - | PASD1 | chrX | 150828185 | + |
| In-frame | ENST00000406877 | ENST00000370357 | CDCA7L | chr7 | 21956372 | - | PASD1 | chrX | 150828185 | + |
| In-frame | ENST00000373934 | ENST00000370357 | CDCA7L | chr7 | 21956372 | - | PASD1 | chrX | 150828185 | + |
| 5UTR-3CDS | ENST00000465490 | ENST00000370357 | CDCA7L | chr7 | 21956372 | - | PASD1 | chrX | 150828185 | + |
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FusionProtFeatures for CDCA7L_PASD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDCA7L | PASD1 |