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Fusion gene ID: 638 |
FusionGeneSummary for ACTR3_ZRANB3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACTR3_ZRANB3 | Fusion gene ID: 638 | Hgene | Tgene | Gene symbol | ACTR3 | ZRANB3 | Gene ID | 10096 | 84083 |
| Gene name | ARP3 actin related protein 3 homolog | zinc finger RANBP2-type containing 3 | |
| Synonyms | ARP3 | 4933425L19Rik|AH2 | |
| Cytomap | 2q14.1 | 2q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | actin-related protein 3actin-like protein 3 | DNA annealing helicase and endonuclease ZRANB3annealing helicase 2zinc finger Ran-binding domain-containing protein 3zinc finger, RAN-binding domain containing 3 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P61158 | Q5FWF4 | |
| Ensembl transtripts involved in fusion gene | ENST00000263238, ENST00000536059, ENST00000535589, | ENST00000412849, ENST00000401392, ENST00000264159, ENST00000536680, | |
| Fusion gene scores | * DoF score | 10 X 9 X 5=450 | 5 X 5 X 3=75 |
| # samples | 10 | 6 | |
| ** MAII score | log2(10/450*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ACTR3 [Title/Abstract] AND ZRANB3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACTR3 | GO:0034314 | Arp2/3 complex-mediated actin nucleation | 11741539 |
| Tgene | ZRANB3 | GO:0006281 | DNA repair | 22759634 |
| Tgene | ZRANB3 | GO:0006974 | cellular response to DNA damage stimulus | 22704558|22705370|22759634 |
| Tgene | ZRANB3 | GO:0009411 | response to UV | 22704558 |
| Tgene | ZRANB3 | GO:0031297 | replication fork processing | 22704558|22705370 |
| Tgene | ZRANB3 | GO:0036292 | DNA rewinding | 21078962|22705370 |
| Tgene | ZRANB3 | GO:0045910 | negative regulation of DNA recombination | 22704558 |
| Tgene | ZRANB3 | GO:0048478 | replication fork protection | 22704558|22705370 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-V1-A8WS-01A | ACTR3 | chr2 | 114699936 | + | ZRANB3 | chr2 | 135988497 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000263238 | ENST00000412849 | ACTR3 | chr2 | 114699936 | + | ZRANB3 | chr2 | 135988497 | - |
| 5CDS-5UTR | ENST00000263238 | ENST00000401392 | ACTR3 | chr2 | 114699936 | + | ZRANB3 | chr2 | 135988497 | - |
| 5CDS-5UTR | ENST00000263238 | ENST00000264159 | ACTR3 | chr2 | 114699936 | + | ZRANB3 | chr2 | 135988497 | - |
| 5CDS-5UTR | ENST00000263238 | ENST00000536680 | ACTR3 | chr2 | 114699936 | + | ZRANB3 | chr2 | 135988497 | - |
| 5CDS-5UTR | ENST00000536059 | ENST00000412849 | ACTR3 | chr2 | 114699936 | + | ZRANB3 | chr2 | 135988497 | - |
| 5CDS-5UTR | ENST00000536059 | ENST00000401392 | ACTR3 | chr2 | 114699936 | + | ZRANB3 | chr2 | 135988497 | - |
| 5CDS-5UTR | ENST00000536059 | ENST00000264159 | ACTR3 | chr2 | 114699936 | + | ZRANB3 | chr2 | 135988497 | - |
| 5CDS-5UTR | ENST00000536059 | ENST00000536680 | ACTR3 | chr2 | 114699936 | + | ZRANB3 | chr2 | 135988497 | - |
| 5CDS-5UTR | ENST00000535589 | ENST00000412849 | ACTR3 | chr2 | 114699936 | + | ZRANB3 | chr2 | 135988497 | - |
| 5CDS-5UTR | ENST00000535589 | ENST00000401392 | ACTR3 | chr2 | 114699936 | + | ZRANB3 | chr2 | 135988497 | - |
| 5CDS-5UTR | ENST00000535589 | ENST00000264159 | ACTR3 | chr2 | 114699936 | + | ZRANB3 | chr2 | 135988497 | - |
| 5CDS-5UTR | ENST00000535589 | ENST00000536680 | ACTR3 | chr2 | 114699936 | + | ZRANB3 | chr2 | 135988497 | - |
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FusionProtFeatures for ACTR3_ZRANB3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACTR3 | ZRANB3 |