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Fusion gene ID: 6254 |
FusionGeneSummary for CD74_NTRK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CD74_NTRK1 | Fusion gene ID: 6254 | Hgene | Tgene | Gene symbol | CD74 | NTRK1 | Gene ID | 972 | 4914 |
| Gene name | CD74 molecule | neurotrophic receptor tyrosine kinase 1 | |
| Synonyms | DHLAG|HLADG|II|Ia-GAMMA | MTC|TRK|TRK1|TRKA|Trk-A|p140-TrkA | |
| Cytomap | 5q33.1 | 1q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | HLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated | high affinity nerve growth factor receptorOncogene TRKTRK1-transforming tyrosine kinase proteingp140trkneurotrophic tyrosine kinase, receptor, type 1tropomyosin-related kinase Atyrosine kinase receptor A | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P04233 | P04629 | |
| Ensembl transtripts involved in fusion gene | ENST00000377795, ENST00000353334, ENST00000524315, ENST00000009530, | ENST00000392302, ENST00000368196, ENST00000524377, ENST00000358660, ENST00000531606, | |
| Fusion gene scores | * DoF score | 33 X 31 X 10=10230 | 15 X 12 X 8=1440 |
| # samples | 48 | 23 | |
| ** MAII score | log2(48/10230*10)=-4.41362792902417 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(23/1440*10)=-2.6463630453853 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CD74 [Title/Abstract] AND NTRK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CD74 | GO:0001516 | prostaglandin biosynthetic process | 12782713 |
| Hgene | CD74 | GO:0001934 | positive regulation of protein phosphorylation | 24942581 |
| Hgene | CD74 | GO:0002792 | negative regulation of peptide secretion | 19849849 |
| Hgene | CD74 | GO:0007165 | signal transduction | 12782713 |
| Hgene | CD74 | GO:0008283 | cell proliferation | 12782713 |
| Hgene | CD74 | GO:0033674 | positive regulation of kinase activity | 24942581 |
| Hgene | CD74 | GO:0043066 | negative regulation of apoptotic process | 12782713 |
| Hgene | CD74 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 24942581 |
| Hgene | CD74 | GO:0043410 | positive regulation of MAPK cascade | 24942581 |
| Hgene | CD74 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 17045821 |
| Hgene | CD74 | GO:0045657 | positive regulation of monocyte differentiation | 24942581 |
| Hgene | CD74 | GO:0045893 | positive regulation of transcription, DNA-templated | 24942581 |
| Hgene | CD74 | GO:0046598 | positive regulation of viral entry into host cell | 24942581 |
| Hgene | CD74 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 17045821 |
| Hgene | CD74 | GO:0051290 | protein heterotetramerization | 24942581 |
| Hgene | CD74 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 17045821|24942581 |
| Tgene | NTRK1 | GO:0006468 | protein phosphorylation | 15488758 |
| Tgene | NTRK1 | GO:0008285 | negative regulation of cell proliferation | 15488758 |
| Tgene | NTRK1 | GO:0010976 | positive regulation of neuron projection development | 15488758 |
| Tgene | NTRK1 | GO:0018108 | peptidyl-tyrosine phosphorylation | 2927393 |
| Tgene | NTRK1 | GO:0043547 | positive regulation of GTPase activity | 15488758 |
| Tgene | NTRK1 | GO:0046579 | positive regulation of Ras protein signal transduction | 15488758 |
| Tgene | NTRK1 | GO:0046777 | protein autophosphorylation | 15488758 |
| Tgene | NTRK1 | GO:0048011 | neurotrophin TRK receptor signaling pathway | 15488758 |
| Tgene | NTRK1 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 15488758 |
| Tgene | NTRK1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 15488758 |
| Tgene | NTRK1 | GO:1904646 | cellular response to amyloid-beta | 11927634 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | HG532018 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000377795 | ENST00000392302 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| 3UTR-3CDS | ENST00000377795 | ENST00000368196 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| 3UTR-3CDS | ENST00000377795 | ENST00000524377 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| 3UTR-3CDS | ENST00000377795 | ENST00000358660 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| 3UTR-intron | ENST00000377795 | ENST00000531606 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| In-frame | ENST00000353334 | ENST00000392302 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| In-frame | ENST00000353334 | ENST00000368196 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| In-frame | ENST00000353334 | ENST00000524377 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| In-frame | ENST00000353334 | ENST00000358660 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| 5CDS-intron | ENST00000353334 | ENST00000531606 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| intron-3CDS | ENST00000524315 | ENST00000392302 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| intron-3CDS | ENST00000524315 | ENST00000368196 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| intron-3CDS | ENST00000524315 | ENST00000524377 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| intron-3CDS | ENST00000524315 | ENST00000358660 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| intron-intron | ENST00000524315 | ENST00000531606 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| In-frame | ENST00000009530 | ENST00000392302 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| In-frame | ENST00000009530 | ENST00000368196 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| In-frame | ENST00000009530 | ENST00000524377 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| In-frame | ENST00000009530 | ENST00000358660 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
| 5CDS-intron | ENST00000009530 | ENST00000531606 | CD74 | chr5 | 149782126 | - | NTRK1 | chr1 | 156844360 | + |
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FusionProtFeatures for CD74_NTRK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CD74 | NTRK1 |