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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6241

FusionGeneSummary for CD74_CD74

check button Fusion gene summary
Fusion gene informationFusion gene name: CD74_CD74
Fusion gene ID: 6241
HgeneTgene
Gene symbol

CD74

CD74

Gene ID

972

972

Gene nameCD74 moleculeCD74 molecule
SynonymsDHLAG|HLADG|II|Ia-GAMMADHLAG|HLADG|II|Ia-GAMMA
Cytomap

5q33.1

5q33.1

Type of geneprotein-codingprotein-coding
DescriptionHLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated HLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated
Modification date2018052220180522
UniProtAcc

P04233

P04233

Ensembl transtripts involved in fusion geneENST00000377795, ENST00000353334, 
ENST00000524315, ENST00000009530, 
ENST00000377795, ENST00000353334, 
ENST00000524315, ENST00000009530, 
Fusion gene scores* DoF score33 X 31 X 10=1023016 X 15 X 5=1200
# samples 4827
** MAII scorelog2(48/10230*10)=-4.41362792902417
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/1200*10)=-2.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD74 [Title/Abstract] AND CD74 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD74

GO:0001516

prostaglandin biosynthetic process

12782713

HgeneCD74

GO:0001934

positive regulation of protein phosphorylation

24942581

HgeneCD74

GO:0002792

negative regulation of peptide secretion

19849849

HgeneCD74

GO:0007165

signal transduction

12782713

HgeneCD74

GO:0008283

cell proliferation

12782713

HgeneCD74

GO:0033674

positive regulation of kinase activity

24942581

HgeneCD74

GO:0043066

negative regulation of apoptotic process

12782713

HgeneCD74

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

24942581

HgeneCD74

GO:0043410

positive regulation of MAPK cascade

24942581

HgeneCD74

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

17045821

HgeneCD74

GO:0045657

positive regulation of monocyte differentiation

24942581

HgeneCD74

GO:0045893

positive regulation of transcription, DNA-templated

24942581

HgeneCD74

GO:0046598

positive regulation of viral entry into host cell

24942581

HgeneCD74

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

17045821

HgeneCD74

GO:0051290

protein heterotetramerization

24942581

HgeneCD74

GO:0070374

positive regulation of ERK1 and ERK2 cascade

17045821|24942581

TgeneCD74

GO:0001516

prostaglandin biosynthetic process

12782713

TgeneCD74

GO:0001934

positive regulation of protein phosphorylation

24942581

TgeneCD74

GO:0002792

negative regulation of peptide secretion

19849849

TgeneCD74

GO:0007165

signal transduction

12782713

TgeneCD74

GO:0008283

cell proliferation

12782713

TgeneCD74

GO:0033674

positive regulation of kinase activity

24942581

TgeneCD74

GO:0043066

negative regulation of apoptotic process

12782713

TgeneCD74

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

24942581

TgeneCD74

GO:0043410

positive regulation of MAPK cascade

24942581

TgeneCD74

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

17045821

TgeneCD74

GO:0045657

positive regulation of monocyte differentiation

24942581

TgeneCD74

GO:0045893

positive regulation of transcription, DNA-templated

24942581

TgeneCD74

GO:0046598

positive regulation of viral entry into host cell

24942581

TgeneCD74

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

17045821

TgeneCD74

GO:0051290

protein heterotetramerization

24942581

TgeneCD74

GO:0070374

positive regulation of ERK1 and ERK2 cascade

17045821|24942581


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA731479CD74chr5

149781474

+CD74chr5

149781536

-
ChiTaRS3.1H20340CD74chr5

149781523

+CD74chr5

149781367

-
ChiTaRS3.1AW512420CD74chr5

149781493

+CD74chr5

149792295

-
ChiTaRS3.1AW974280CD74chr5

149781293

-CD74chr5

149781208

+
ChiTaRS3.1H20291CD74chr5

149781367

+CD74chr5

149781523

-
ChiTaRS3.1AA593162CD74chr5

149781293

-CD74chr5

149781208

+
ChiTaRS3.1AA262125CD74chr5

149781727

+CD74chr5

149781467

-
ChiTaRS3.1H21087CD74chr5

149781367

+CD74chr5

149781523

-
ChiTaRS3.1H20268CD74chr5

149781367

+CD74chr5

149781523

-
ChiTaRS3.1H22438CD74chr5

149781367

+CD74chr5

149781523

-
ChiTaRS3.1H42916CD74chr5

149781367

+CD74chr5

149781523

-
ChiTaRS3.1BU618143CD74chr5

149781270

+CD74chr5

149792310

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000377795ENST00000377795CD74chr5

149781474

+CD74chr5

149781536

-
intron-3UTRENST00000377795ENST00000353334CD74chr5

149781474

+CD74chr5

149781536

-
intron-3UTRENST00000377795ENST00000524315CD74chr5

149781474

+CD74chr5

149781536

-
intron-intronENST00000377795ENST00000009530CD74chr5

149781474

+CD74chr5

149781536

-
intron-3UTRENST00000353334ENST00000377795CD74chr5

149781474

+CD74chr5

149781536

-
intron-3UTRENST00000353334ENST00000353334CD74chr5

149781474

+CD74chr5

149781536

-
intron-3UTRENST00000353334ENST00000524315CD74chr5

149781474

+CD74chr5

149781536

-
intron-intronENST00000353334ENST00000009530CD74chr5

149781474

+CD74chr5

149781536

-
intron-3UTRENST00000524315ENST00000377795CD74chr5

149781474

+CD74chr5

149781536

-
intron-3UTRENST00000524315ENST00000353334CD74chr5

149781474

+CD74chr5

149781536

-
intron-3UTRENST00000524315ENST00000524315CD74chr5

149781474

+CD74chr5

149781536

-
intron-intronENST00000524315ENST00000009530CD74chr5

149781474

+CD74chr5

149781536

-
intron-3UTRENST00000009530ENST00000377795CD74chr5

149781474

+CD74chr5

149781536

-
intron-3UTRENST00000009530ENST00000353334CD74chr5

149781474

+CD74chr5

149781536

-
intron-3UTRENST00000009530ENST00000524315CD74chr5

149781474

+CD74chr5

149781536

-
intron-intronENST00000009530ENST00000009530CD74chr5

149781474

+CD74chr5

149781536

-
intron-3UTRENST00000377795ENST00000377795CD74chr5

149781523

+CD74chr5

149781367

-
intron-3UTRENST00000377795ENST00000353334CD74chr5

149781523

+CD74chr5

149781367

-
intron-intronENST00000377795ENST00000524315CD74chr5

149781523

+CD74chr5

149781367

-
intron-intronENST00000377795ENST00000009530CD74chr5

149781523

+CD74chr5

149781367

-
intron-3UTRENST00000353334ENST00000377795CD74chr5

149781523

+CD74chr5

149781367

-
intron-3UTRENST00000353334ENST00000353334CD74chr5

149781523

+CD74chr5

149781367

-
intron-intronENST00000353334ENST00000524315CD74chr5

149781523

+CD74chr5

149781367

-
intron-intronENST00000353334ENST00000009530CD74chr5

149781523

+CD74chr5

149781367

-
intron-3UTRENST00000524315ENST00000377795CD74chr5

149781523

+CD74chr5

149781367

-
intron-3UTRENST00000524315ENST00000353334CD74chr5

149781523

+CD74chr5

149781367

-
intron-intronENST00000524315ENST00000524315CD74chr5

149781523

+CD74chr5

149781367

-
intron-intronENST00000524315ENST00000009530CD74chr5

149781523

+CD74chr5

149781367

-
intron-3UTRENST00000009530ENST00000377795CD74chr5

149781523

+CD74chr5

149781367

-
intron-3UTRENST00000009530ENST00000353334CD74chr5

149781523

+CD74chr5

149781367

-
intron-intronENST00000009530ENST00000524315CD74chr5

149781523

+CD74chr5

149781367

-
intron-intronENST00000009530ENST00000009530CD74chr5

149781523

+CD74chr5

149781367

-
intron-3CDSENST00000377795ENST00000377795CD74chr5

149781493

+CD74chr5

149792295

-
intron-3CDSENST00000377795ENST00000353334CD74chr5

149781493

+CD74chr5

149792295

-
intron-3CDSENST00000377795ENST00000524315CD74chr5

149781493

+CD74chr5

149792295

-
intron-3CDSENST00000377795ENST00000009530CD74chr5

149781493

+CD74chr5

149792295

-
intron-3CDSENST00000353334ENST00000377795CD74chr5

149781493

+CD74chr5

149792295

-
intron-3CDSENST00000353334ENST00000353334CD74chr5

149781493

+CD74chr5

149792295

-
intron-3CDSENST00000353334ENST00000524315CD74chr5

149781493

+CD74chr5

149792295

-
intron-3CDSENST00000353334ENST00000009530CD74chr5

149781493

+CD74chr5

149792295

-
intron-3CDSENST00000524315ENST00000377795CD74chr5

149781493

+CD74chr5

149792295

-
intron-3CDSENST00000524315ENST00000353334CD74chr5

149781493

+CD74chr5

149792295

-
intron-3CDSENST00000524315ENST00000524315CD74chr5

149781493

+CD74chr5

149792295

-
intron-3CDSENST00000524315ENST00000009530CD74chr5

149781493

+CD74chr5

149792295

-
intron-3CDSENST00000009530ENST00000377795CD74chr5

149781493

+CD74chr5

149792295

-
intron-3CDSENST00000009530ENST00000353334CD74chr5

149781493

+CD74chr5

149792295

-
intron-3CDSENST00000009530ENST00000524315CD74chr5

149781493

+CD74chr5

149792295

-
intron-3CDSENST00000009530ENST00000009530CD74chr5

149781493

+CD74chr5

149792295

-
intron-3UTRENST00000377795ENST00000377795CD74chr5

149781293

-CD74chr5

149781208

+
intron-intronENST00000377795ENST00000353334CD74chr5

149781293

-CD74chr5

149781208

+
intron-intronENST00000377795ENST00000524315CD74chr5

149781293

-CD74chr5

149781208

+
intron-intronENST00000377795ENST00000009530CD74chr5

149781293

-CD74chr5

149781208

+
intron-3UTRENST00000353334ENST00000377795CD74chr5

149781293

-CD74chr5

149781208

+
intron-intronENST00000353334ENST00000353334CD74chr5

149781293

-CD74chr5

149781208

+
intron-intronENST00000353334ENST00000524315CD74chr5

149781293

-CD74chr5

149781208

+
intron-intronENST00000353334ENST00000009530CD74chr5

149781293

-CD74chr5

149781208

+
intron-3UTRENST00000524315ENST00000377795CD74chr5

149781293

-CD74chr5

149781208

+
intron-intronENST00000524315ENST00000353334CD74chr5

149781293

-CD74chr5

149781208

+
intron-intronENST00000524315ENST00000524315CD74chr5

149781293

-CD74chr5

149781208

+
intron-intronENST00000524315ENST00000009530CD74chr5

149781293

-CD74chr5

149781208

+
intron-3UTRENST00000009530ENST00000377795CD74chr5

149781293

-CD74chr5

149781208

+
intron-intronENST00000009530ENST00000353334CD74chr5

149781293

-CD74chr5

149781208

+
intron-intronENST00000009530ENST00000524315CD74chr5

149781293

-CD74chr5

149781208

+
intron-intronENST00000009530ENST00000009530CD74chr5

149781293

-CD74chr5

149781208

+
intron-3UTRENST00000377795ENST00000377795CD74chr5

149781367

+CD74chr5

149781523

-
intron-3UTRENST00000377795ENST00000353334CD74chr5

149781367

+CD74chr5

149781523

-
intron-3UTRENST00000377795ENST00000524315CD74chr5

149781367

+CD74chr5

149781523

-
intron-intronENST00000377795ENST00000009530CD74chr5

149781367

+CD74chr5

149781523

-
intron-3UTRENST00000353334ENST00000377795CD74chr5

149781367

+CD74chr5

149781523

-
intron-3UTRENST00000353334ENST00000353334CD74chr5

149781367

+CD74chr5

149781523

-
intron-3UTRENST00000353334ENST00000524315CD74chr5

149781367

+CD74chr5

149781523

-
intron-intronENST00000353334ENST00000009530CD74chr5

149781367

+CD74chr5

149781523

-
intron-3UTRENST00000524315ENST00000377795CD74chr5

149781367

+CD74chr5

149781523

-
intron-3UTRENST00000524315ENST00000353334CD74chr5

149781367

+CD74chr5

149781523

-
intron-3UTRENST00000524315ENST00000524315CD74chr5

149781367

+CD74chr5

149781523

-
intron-intronENST00000524315ENST00000009530CD74chr5

149781367

+CD74chr5

149781523

-
intron-3UTRENST00000009530ENST00000377795CD74chr5

149781367

+CD74chr5

149781523

-
intron-3UTRENST00000009530ENST00000353334CD74chr5

149781367

+CD74chr5

149781523

-
intron-3UTRENST00000009530ENST00000524315CD74chr5

149781367

+CD74chr5

149781523

-
intron-intronENST00000009530ENST00000009530CD74chr5

149781367

+CD74chr5

149781523

-
intron-3UTRENST00000377795ENST00000377795CD74chr5

149781727

+CD74chr5

149781467

-
intron-3UTRENST00000377795ENST00000353334CD74chr5

149781727

+CD74chr5

149781467

-
intron-3UTRENST00000377795ENST00000524315CD74chr5

149781727

+CD74chr5

149781467

-
intron-intronENST00000377795ENST00000009530CD74chr5

149781727

+CD74chr5

149781467

-
intron-3UTRENST00000353334ENST00000377795CD74chr5

149781727

+CD74chr5

149781467

-
intron-3UTRENST00000353334ENST00000353334CD74chr5

149781727

+CD74chr5

149781467

-
intron-3UTRENST00000353334ENST00000524315CD74chr5

149781727

+CD74chr5

149781467

-
intron-intronENST00000353334ENST00000009530CD74chr5

149781727

+CD74chr5

149781467

-
intron-3UTRENST00000524315ENST00000377795CD74chr5

149781727

+CD74chr5

149781467

-
intron-3UTRENST00000524315ENST00000353334CD74chr5

149781727

+CD74chr5

149781467

-
intron-3UTRENST00000524315ENST00000524315CD74chr5

149781727

+CD74chr5

149781467

-
intron-intronENST00000524315ENST00000009530CD74chr5

149781727

+CD74chr5

149781467

-
intron-3UTRENST00000009530ENST00000377795CD74chr5

149781727

+CD74chr5

149781467

-
intron-3UTRENST00000009530ENST00000353334CD74chr5

149781727

+CD74chr5

149781467

-
intron-3UTRENST00000009530ENST00000524315CD74chr5

149781727

+CD74chr5

149781467

-
intron-intronENST00000009530ENST00000009530CD74chr5

149781727

+CD74chr5

149781467

-
intron-3CDSENST00000377795ENST00000377795CD74chr5

149781270

+CD74chr5

149792310

-
intron-3CDSENST00000377795ENST00000353334CD74chr5

149781270

+CD74chr5

149792310

-
intron-3CDSENST00000377795ENST00000524315CD74chr5

149781270

+CD74chr5

149792310

-
intron-3CDSENST00000377795ENST00000009530CD74chr5

149781270

+CD74chr5

149792310

-
intron-3CDSENST00000353334ENST00000377795CD74chr5

149781270

+CD74chr5

149792310

-
intron-3CDSENST00000353334ENST00000353334CD74chr5

149781270

+CD74chr5

149792310

-
intron-3CDSENST00000353334ENST00000524315CD74chr5

149781270

+CD74chr5

149792310

-
intron-3CDSENST00000353334ENST00000009530CD74chr5

149781270

+CD74chr5

149792310

-
intron-3CDSENST00000524315ENST00000377795CD74chr5

149781270

+CD74chr5

149792310

-
intron-3CDSENST00000524315ENST00000353334CD74chr5

149781270

+CD74chr5

149792310

-
intron-3CDSENST00000524315ENST00000524315CD74chr5

149781270

+CD74chr5

149792310

-
intron-3CDSENST00000524315ENST00000009530CD74chr5

149781270

+CD74chr5

149792310

-
intron-3CDSENST00000009530ENST00000377795CD74chr5

149781270

+CD74chr5

149792310

-
intron-3CDSENST00000009530ENST00000353334CD74chr5

149781270

+CD74chr5

149792310

-
intron-3CDSENST00000009530ENST00000524315CD74chr5

149781270

+CD74chr5

149792310

-
intron-3CDSENST00000009530ENST00000009530CD74chr5

149781270

+CD74chr5

149792310

-

Top

FusionProtFeatures for CD74_CD74


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD74

P04233

CD74

P04233