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Fusion gene ID: 6181

FusionGeneSummary for CD44_CAPRIN1

Fusion gene summary

Fusion gene information	Fusion gene name: CD44_CAPRIN1
	Fusion gene ID: 6181
		Hgene	Tgene
	Gene symbol	CD44	CAPRIN1
	Gene ID	960	4076
	Gene name	CD44 molecule (Indian blood group)	cell cycle associated protein 1
	Synonyms	CDW44\|CSPG8\|ECMR-III\|HCELL\|HUTCH-I\|IN\|LHR\|MC56\|MDU2\|MDU3\|MIC4\|Pgp1	GPIAP1\|GPIP137\|GRIP137\|M11S1\|RNG105\|p137GPI
	Cytomap	11p13	11p13
	Type of gene	protein-coding	protein-coding
	Description	CD44 antigenGP90 lymphocyte homing/adhesion receptorHermes antigencell surface glycoprotein CD44chondroitin sulfate proteoglycan 8epicanextracellular matrix receptor IIIhematopoietic cell E- and L-selectin ligandheparan sulfate proteoglycanhoming	caprin-1GPI-anchored membrane protein 1GPI-anchored protein p137GPI-p137RNA granule protein 105activation/proliferation-associated protein 1caprin 1cytoplasmic activation- and proliferation-associated protein 1cytoplasmic activation/proliferation-
	Modification date	20180527	20180519
	UniProtAcc	P16070	Q14444
	Ensembl transtripts involved in fusion gene	ENST00000263398, ENST00000526025, ENST00000449691, ENST00000360158, ENST00000415148, ENST00000437706, ENST00000433354, ENST00000428726, ENST00000526669, ENST00000433892, ENST00000278386, ENST00000434472, ENST00000352818, ENST00000528922,	ENST00000341394, ENST00000389645, ENST00000532820, ENST00000530820, ENST00000529307, ENST00000533657,
Fusion gene scores	* DoF score	11 X 10 X 7=770	6 X 5 X 4=120
	# samples	14	8
	** MAII score	log2(14/770*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CD44 [Title/Abstract] AND CAPRIN1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CD44	GO:0030214	hyaluronan catabolic process	17170110
Hgene	CD44	GO:0033138	positive regulation of peptidyl-serine phosphorylation	17045821
Hgene	CD44	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	17045821
Hgene	CD44	GO:0044344	cellular response to fibroblast growth factor stimulus	19577615
Hgene	CD44	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	17045821
Hgene	CD44	GO:0070374	positive regulation of ERK1 and ERK2 cascade	17045821
Hgene	CD44	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	17045821

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	UCS	TCGA-NG-A4VU-01A	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
TCGA	LD	UCS	TCGA-N5-A4RO-01A	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000263398	ENST00000341394	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000263398	ENST00000389645	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000263398	ENST00000532820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000263398	ENST00000530820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000263398	ENST00000529307	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
5CDS-intron	ENST00000263398	ENST00000533657	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000526025	ENST00000341394	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000526025	ENST00000389645	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000526025	ENST00000532820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000526025	ENST00000530820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000526025	ENST00000529307	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
5CDS-intron	ENST00000526025	ENST00000533657	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000449691	ENST00000341394	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000449691	ENST00000389645	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000449691	ENST00000532820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000449691	ENST00000530820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000449691	ENST00000529307	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
5CDS-intron	ENST00000449691	ENST00000533657	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000360158	ENST00000341394	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000360158	ENST00000389645	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000360158	ENST00000532820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000360158	ENST00000530820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000360158	ENST00000529307	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
5CDS-intron	ENST00000360158	ENST00000533657	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000415148	ENST00000341394	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000415148	ENST00000389645	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000415148	ENST00000532820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000415148	ENST00000530820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000415148	ENST00000529307	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
5CDS-intron	ENST00000415148	ENST00000533657	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000437706	ENST00000341394	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000437706	ENST00000389645	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000437706	ENST00000532820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000437706	ENST00000530820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000437706	ENST00000529307	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
5CDS-intron	ENST00000437706	ENST00000533657	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000433354	ENST00000341394	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000433354	ENST00000389645	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000433354	ENST00000532820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000433354	ENST00000530820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000433354	ENST00000529307	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
5CDS-intron	ENST00000433354	ENST00000533657	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000428726	ENST00000341394	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000428726	ENST00000389645	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000428726	ENST00000532820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000428726	ENST00000530820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000428726	ENST00000529307	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
5CDS-intron	ENST00000428726	ENST00000533657	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000526669	ENST00000341394	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000526669	ENST00000389645	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000526669	ENST00000532820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000526669	ENST00000530820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000526669	ENST00000529307	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
5CDS-intron	ENST00000526669	ENST00000533657	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000433892	ENST00000341394	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000433892	ENST00000389645	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000433892	ENST00000532820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000433892	ENST00000530820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000433892	ENST00000529307	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
5CDS-intron	ENST00000433892	ENST00000533657	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000278386	ENST00000341394	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000278386	ENST00000389645	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000278386	ENST00000532820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000278386	ENST00000530820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000278386	ENST00000529307	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
5CDS-intron	ENST00000278386	ENST00000533657	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000434472	ENST00000341394	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000434472	ENST00000389645	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000434472	ENST00000532820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000434472	ENST00000530820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000434472	ENST00000529307	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
5CDS-intron	ENST00000434472	ENST00000533657	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000352818	ENST00000341394	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000352818	ENST00000389645	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000352818	ENST00000532820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000352818	ENST00000530820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
In-frame	ENST00000352818	ENST00000529307	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
5CDS-intron	ENST00000352818	ENST00000533657	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
intron-3CDS	ENST00000528922	ENST00000341394	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
intron-3CDS	ENST00000528922	ENST00000389645	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
intron-3CDS	ENST00000528922	ENST00000532820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
intron-3CDS	ENST00000528922	ENST00000530820	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
intron-3CDS	ENST00000528922	ENST00000529307	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
intron-intron	ENST00000528922	ENST00000533657	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+

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FusionProtFeatures for CD44_CAPRIN1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CD44 P16070	CAPRIN1 Q14444

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Fusion gene ID: 6181

FusionGeneSummary for CD44_CAPRIN1

FusionProtFeatures for CD44_CAPRIN1