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Fusion gene ID: 6139

FusionGeneSummary for CD244_AHCYL2

Fusion gene summary

Fusion gene information	Fusion gene name: CD244_AHCYL2
	Fusion gene ID: 6139
		Hgene	Tgene
	Gene symbol	CD244	AHCYL2
	Gene ID	51744	23382
	Gene name	CD244 molecule	adenosylhomocysteinase like 2
	Synonyms	2B4\|NAIL\|NKR2B4\|Nmrk\|SLAMF4	ADOHCYASE3\|IRBIT2
	Cytomap	1q23.3	7q32.1
	Type of gene	protein-coding	protein-coding
	Description	natural killer cell receptor 2B4CD244 molecule, natural killer cell receptor 2B4NK cell activation inducing ligand NAILNK cell activation-inducing ligandNK cell type I receptor protein 2B4SLAM family member 4h2B4signaling lymphocytic activation mol	adenosylhomocysteinase 3IP(3)Rs binding protein released with IP(3) 2S-adenosyl-L-homocysteine hydrolase 3S-adenosylhomocysteine hydrolase-like 2long-IRBITputative adenosylhomocysteinase 3
	Modification date	20180519	20180523
	UniProtAcc	Q9BZW8	Q96HN2
	Ensembl transtripts involved in fusion gene	ENST00000368034, ENST00000368033, ENST00000322302, ENST00000368032, ENST00000481677,	ENST00000325006, ENST00000446544, ENST00000531335, ENST00000474594, ENST00000446212, ENST00000490911, ENST00000472554,
Fusion gene scores	* DoF score	2 X 2 X 2=8	7 X 5 X 5=175
	# samples	2	7
	** MAII score	log2(2/8*10)=1.32192809488736	log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CD244 [Title/Abstract] AND AHCYL2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CD244	GO:0002323	natural killer cell activation involved in immune response	11714776
Hgene	CD244	GO:0060732	positive regulation of inositol phosphate biosynthetic process	8376943
Hgene	CD244	GO:0071663	positive regulation of granzyme B production	11714776
Hgene	CD244	GO:1902715	positive regulation of interferon-gamma secretion	11714776
Hgene	CD244	GO:2000484	positive regulation of interleukin-8 secretion	8376943

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AW947006	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000368034	ENST00000325006	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000368034	ENST00000446544	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000368034	ENST00000531335	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-intron	ENST00000368034	ENST00000474594	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000368034	ENST00000446212	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-intron	ENST00000368034	ENST00000490911	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-intron	ENST00000368034	ENST00000472554	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000368033	ENST00000325006	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000368033	ENST00000446544	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000368033	ENST00000531335	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-intron	ENST00000368033	ENST00000474594	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000368033	ENST00000446212	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-intron	ENST00000368033	ENST00000490911	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-intron	ENST00000368033	ENST00000472554	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000322302	ENST00000325006	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000322302	ENST00000446544	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000322302	ENST00000531335	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-intron	ENST00000322302	ENST00000474594	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000322302	ENST00000446212	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-intron	ENST00000322302	ENST00000490911	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-intron	ENST00000322302	ENST00000472554	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000368032	ENST00000325006	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000368032	ENST00000446544	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000368032	ENST00000531335	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-intron	ENST00000368032	ENST00000474594	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000368032	ENST00000446212	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-intron	ENST00000368032	ENST00000490911	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-intron	ENST00000368032	ENST00000472554	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000481677	ENST00000325006	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000481677	ENST00000446544	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000481677	ENST00000531335	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-intron	ENST00000481677	ENST00000474594	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-3UTR	ENST00000481677	ENST00000446212	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-intron	ENST00000481677	ENST00000490911	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-
intron-intron	ENST00000481677	ENST00000472554	CD244	chr1	160810825	+	AHCYL2	chr7	129069615	-

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FusionProtFeatures for CD244_AHCYL2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CD244 Q9BZW8	AHCYL2 Q96HN2

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Fusion gene ID: 6139

FusionGeneSummary for CD244_AHCYL2

FusionProtFeatures for CD244_AHCYL2