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Fusion gene ID: 6083 |
FusionGeneSummary for CCT2_CXCR5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCT2_CXCR5 | Fusion gene ID: 6083 | Hgene | Tgene | Gene symbol | CCT2 | CXCR5 | Gene ID | 10576 | 643 |
| Gene name | chaperonin containing TCP1 subunit 2 | C-X-C motif chemokine receptor 5 | |
| Synonyms | 99D8.1|CCT-beta|CCTB|HEL-S-100n|PRO1633|TCP-1-beta | BLR1|CD185|MDR15 | |
| Cytomap | 12q15 | 11q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | T-complex protein 1 subunit betaT-complex protein 1, beta subunitchaperonin containing TCP1, subunit 2 (beta)chaperonin containing t-complex polypeptide 1, beta subunitchaperonin containing t-complex polypeptide 1, subunit 2epididymis secretory sperm | C-X-C chemokine receptor type 5Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)Burkitt lymphoma receptor 1, GTP-binding proteinCXC-R5CXCR-5MDR-15chemokine (C-X-C motif) receptor 5monocyte-derived receptor 15 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P78371 | P32302 | |
| Ensembl transtripts involved in fusion gene | ENST00000299300, ENST00000544368, ENST00000543146, | ENST00000292174, | |
| Fusion gene scores | * DoF score | 11 X 9 X 7=693 | 11 X 3 X 7=231 |
| # samples | 13 | 11 | |
| ** MAII score | log2(13/693*10)=-2.41434372910876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/231*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CCT2 [Title/Abstract] AND CXCR5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E9-A22B-01A | CCT2 | chr12 | 69995350 | + | CXCR5 | chr11 | 118754475 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000299300 | ENST00000292174 | CCT2 | chr12 | 69995350 | + | CXCR5 | chr11 | 118754475 | + |
| intron-3CDS | ENST00000544368 | ENST00000292174 | CCT2 | chr12 | 69995350 | + | CXCR5 | chr11 | 118754475 | + |
| Frame-shift | ENST00000543146 | ENST00000292174 | CCT2 | chr12 | 69995350 | + | CXCR5 | chr11 | 118754475 | + |
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FusionProtFeatures for CCT2_CXCR5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCT2 | CXCR5 |