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Fusion gene ID: 6016 |
FusionGeneSummary for CCNG2_SLC4A4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCNG2_SLC4A4 | Fusion gene ID: 6016 | Hgene | Tgene | Gene symbol | CCNG2 | SLC4A4 | Gene ID | 901 | 8671 |
| Gene name | cyclin G2 | solute carrier family 4 member 4 | |
| Synonyms | - | HNBC1|KNBC|NBC1|NBC2|NBCe1-A|SLC4A5|hhNMC|kNBC1|pNBC | |
| Cytomap | 4q21.1 | 4q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclin-G2 | electrogenic sodium bicarbonate cotransporter 1Na(+)/HCO3(-) cotransportersodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas)solute carrier family 4 (sodium bicarbonate cotransporter | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q16589 | Q9Y6R1 | |
| Ensembl transtripts involved in fusion gene | ENST00000497512, ENST00000316355, ENST00000354403, ENST00000502280, ENST00000395640, ENST00000509972, | ENST00000264485, ENST00000425175, ENST00000351898, ENST00000340595, ENST00000514331, ENST00000512686, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 10 X 8 X 5=400 |
| # samples | 1 | 11 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(11/400*10)=-1.86249647625006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CCNG2 [Title/Abstract] AND SLC4A4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SLC4A4 | GO:0006814 | sodium ion transport | 16769890 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-CH-5751-01A | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-5UTR | ENST00000497512 | ENST00000264485 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 3UTR-5UTR | ENST00000497512 | ENST00000425175 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 3UTR-5UTR | ENST00000497512 | ENST00000351898 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 3UTR-intron | ENST00000497512 | ENST00000340595 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 3UTR-intron | ENST00000497512 | ENST00000514331 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 3UTR-intron | ENST00000497512 | ENST00000512686 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-5UTR | ENST00000316355 | ENST00000264485 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-5UTR | ENST00000316355 | ENST00000425175 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-5UTR | ENST00000316355 | ENST00000351898 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-intron | ENST00000316355 | ENST00000340595 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-intron | ENST00000316355 | ENST00000514331 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-intron | ENST00000316355 | ENST00000512686 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-5UTR | ENST00000354403 | ENST00000264485 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-5UTR | ENST00000354403 | ENST00000425175 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-5UTR | ENST00000354403 | ENST00000351898 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-intron | ENST00000354403 | ENST00000340595 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-intron | ENST00000354403 | ENST00000514331 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-intron | ENST00000354403 | ENST00000512686 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-5UTR | ENST00000502280 | ENST00000264485 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-5UTR | ENST00000502280 | ENST00000425175 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-5UTR | ENST00000502280 | ENST00000351898 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-intron | ENST00000502280 | ENST00000340595 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-intron | ENST00000502280 | ENST00000514331 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-intron | ENST00000502280 | ENST00000512686 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-5UTR | ENST00000395640 | ENST00000264485 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-5UTR | ENST00000395640 | ENST00000425175 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-5UTR | ENST00000395640 | ENST00000351898 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-intron | ENST00000395640 | ENST00000340595 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-intron | ENST00000395640 | ENST00000514331 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-intron | ENST00000395640 | ENST00000512686 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-5UTR | ENST00000509972 | ENST00000264485 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-5UTR | ENST00000509972 | ENST00000425175 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-5UTR | ENST00000509972 | ENST00000351898 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-intron | ENST00000509972 | ENST00000340595 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-intron | ENST00000509972 | ENST00000514331 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
| 5CDS-intron | ENST00000509972 | ENST00000512686 | CCNG2 | chr4 | 78085632 | + | SLC4A4 | chr4 | 72102293 | + |
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FusionProtFeatures for CCNG2_SLC4A4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCNG2 | SLC4A4 |