|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 5987 |
FusionGeneSummary for CCND1_CCND1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCND1_CCND1 | Fusion gene ID: 5987 | Hgene | Tgene | Gene symbol | CCND1 | CCND1 | Gene ID | 595 | 595 |
| Gene name | cyclin D1 | cyclin D1 | |
| Synonyms | BCL1|D11S287E|PRAD1|U21B31 | BCL1|D11S287E|PRAD1|U21B31 | |
| Cytomap | 11q13.3 | 11q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | G1/S-specific cyclin-D1B-cell CLL/lymphoma 1B-cell lymphoma 1 proteinBCL-1 oncogenePRAD1 oncogene | G1/S-specific cyclin-D1B-cell CLL/lymphoma 1B-cell lymphoma 1 proteinBCL-1 oncogenePRAD1 oncogene | |
| Modification date | 20180527 | 20180527 | |
| UniProtAcc | P24385 | P24385 | |
| Ensembl transtripts involved in fusion gene | ENST00000227507, ENST00000536559, | ENST00000227507, ENST00000536559, | |
| Fusion gene scores | * DoF score | 8 X 7 X 3=168 | 10 X 10 X 4=400 |
| # samples | 8 | 10 | |
| ** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/400*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CCND1 [Title/Abstract] AND CCND1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CCND1 | GO:0000082 | G1/S transition of mitotic cell cycle | 19412162 |
| Hgene | CCND1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16569215|18417529 |
| Hgene | CCND1 | GO:0001934 | positive regulation of protein phosphorylation | 8114739 |
| Hgene | CCND1 | GO:0006974 | cellular response to DNA damage stimulus | 19412162 |
| Hgene | CCND1 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle | 19124461 |
| Hgene | CCND1 | GO:0031571 | mitotic G1 DNA damage checkpoint | 19412162 |
| Hgene | CCND1 | GO:0044321 | response to leptin | 17344214 |
| Hgene | CCND1 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | 8114739 |
| Hgene | CCND1 | GO:0070141 | response to UV-A | 18483258 |
| Hgene | CCND1 | GO:0071157 | negative regulation of cell cycle arrest | 19124461 |
| Tgene | CCND1 | GO:0000082 | G1/S transition of mitotic cell cycle | 19412162 |
| Tgene | CCND1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16569215|18417529 |
| Tgene | CCND1 | GO:0001934 | positive regulation of protein phosphorylation | 8114739 |
| Tgene | CCND1 | GO:0006974 | cellular response to DNA damage stimulus | 19412162 |
| Tgene | CCND1 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle | 19124461 |
| Tgene | CCND1 | GO:0031571 | mitotic G1 DNA damage checkpoint | 19412162 |
| Tgene | CCND1 | GO:0044321 | response to leptin | 17344214 |
| Tgene | CCND1 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | 8114739 |
| Tgene | CCND1 | GO:0070141 | response to UV-A | 18483258 |
| Tgene | CCND1 | GO:0071157 | negative regulation of cell cycle arrest | 19124461 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | W24017 | CCND1 | chr11 | 69467944 | + | CCND1 | chr11 | 69462837 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000227507 | ENST00000227507 | CCND1 | chr11 | 69467944 | + | CCND1 | chr11 | 69462837 | + |
| 3UTR-3UTR | ENST00000227507 | ENST00000536559 | CCND1 | chr11 | 69467944 | + | CCND1 | chr11 | 69462837 | + |
| intron-3CDS | ENST00000536559 | ENST00000227507 | CCND1 | chr11 | 69467944 | + | CCND1 | chr11 | 69462837 | + |
| intron-3UTR | ENST00000536559 | ENST00000536559 | CCND1 | chr11 | 69467944 | + | CCND1 | chr11 | 69462837 | + |
Top |
FusionProtFeatures for CCND1_CCND1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCND1 | CCND1 |