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Fusion gene ID: 5967 |
FusionGeneSummary for CCL4_MCL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCL4_MCL1 | Fusion gene ID: 5967 | Hgene | Tgene | Gene symbol | CCL4 | MCL1 | Gene ID | 6351 | 4170 |
| Gene name | C-C motif chemokine ligand 4 | MCL1, BCL2 family apoptosis regulator | |
| Synonyms | ACT2|AT744.1|G-26|HC21|LAG-1|LAG1|MIP-1-beta|MIP1B|MIP1B1|SCYA2|SCYA4 | BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT | |
| Cytomap | 17q12 | 1q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | C-C motif chemokine 4G-26 T-lymphocyte-secreted proteinMIP-1-beta(1-69)PAT 744SIS-gammaT-cell activation protein 2chemokine (C-C motif) ligand 4lymphocyte activation gene 1 proteinmacrophage inflammatory protein 1-betasecreted protein G-26small | induced myeloid leukemia cell differentiation protein Mcl-1BCL2 family apoptosis regulatorbcl-2-like protein 3bcl-2-related protein EAT/mcl1myeloid cell leukemia 1myeloid cell leukemia ESmyeloid cell leukemia sequence 1 (BCL2-related) | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P13236 | Q07820 | |
| Ensembl transtripts involved in fusion gene | ENST00000250151, ENST00000394495, | ENST00000369026, ENST00000464132, ENST00000307940, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 4 X 5 X 1=20 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CCL4 [Title/Abstract] AND MCL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CCL4 | GO:0009636 | response to toxic substance | 10841574 |
| Hgene | CCL4 | GO:0043922 | negative regulation by host of viral transcription | 10841574 |
| Hgene | CCL4 | GO:0051928 | positive regulation of calcium ion transport | 8699119 |
| Hgene | CCL4 | GO:2000503 | positive regulation of natural killer cell chemotaxis | 7545673 |
| Tgene | MCL1 | GO:0034097 | response to cytokine | 9184696 |
| Tgene | MCL1 | GO:0043066 | negative regulation of apoptotic process | 20041405 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CA307816 | CCL4 | chr17 | 34432700 | - | MCL1 | chr1 | 150550874 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000250151 | ENST00000369026 | CCL4 | chr17 | 34432700 | - | MCL1 | chr1 | 150550874 | + |
| 5CDS-5UTR | ENST00000250151 | ENST00000464132 | CCL4 | chr17 | 34432700 | - | MCL1 | chr1 | 150550874 | + |
| 5CDS-intron | ENST00000250151 | ENST00000307940 | CCL4 | chr17 | 34432700 | - | MCL1 | chr1 | 150550874 | + |
| Frame-shift | ENST00000394495 | ENST00000369026 | CCL4 | chr17 | 34432700 | - | MCL1 | chr1 | 150550874 | + |
| 5CDS-5UTR | ENST00000394495 | ENST00000464132 | CCL4 | chr17 | 34432700 | - | MCL1 | chr1 | 150550874 | + |
| 5CDS-intron | ENST00000394495 | ENST00000307940 | CCL4 | chr17 | 34432700 | - | MCL1 | chr1 | 150550874 | + |
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FusionProtFeatures for CCL4_MCL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCL4 | MCL1 |