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Fusion gene ID: 5937 |
FusionGeneSummary for CCDC91_PDZRN4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCDC91_PDZRN4 | Fusion gene ID: 5937 | Hgene | Tgene | Gene symbol | CCDC91 | PDZRN4 | Gene ID | 55297 | 29951 |
| Gene name | coiled-coil domain containing 91 | PDZ domain containing ring finger 4 | |
| Synonyms | HSD8|p56 | LNX4|SAMCAP3L | |
| Cytomap | 12p11.22 | 12q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | coiled-coil domain-containing protein 91GGA-binding partnerp56 accessory protein | PDZ domain-containing RING finger protein 4IMAGE5767589SEMACAP3-like proteinligand of Numb protein X 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q7Z6B0 | Q6ZMN7 | |
| Ensembl transtripts involved in fusion gene | ENST00000539107, ENST00000545336, ENST00000381256, ENST00000381259, ENST00000540401, ENST00000306172, | ENST00000402685, ENST00000539469, ENST00000298919, | |
| Fusion gene scores | * DoF score | 11 X 8 X 7=616 | 10 X 5 X 7=350 |
| # samples | 11 | 10 | |
| ** MAII score | log2(11/616*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/350*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CCDC91 [Title/Abstract] AND PDZRN4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-22-4595-01A | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000539107 | ENST00000402685 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| In-frame | ENST00000539107 | ENST00000539469 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| In-frame | ENST00000539107 | ENST00000298919 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| In-frame | ENST00000545336 | ENST00000402685 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| In-frame | ENST00000545336 | ENST00000539469 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| In-frame | ENST00000545336 | ENST00000298919 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| In-frame | ENST00000381256 | ENST00000402685 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| In-frame | ENST00000381256 | ENST00000539469 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| In-frame | ENST00000381256 | ENST00000298919 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| In-frame | ENST00000381259 | ENST00000402685 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| In-frame | ENST00000381259 | ENST00000539469 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| In-frame | ENST00000381259 | ENST00000298919 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| 3UTR-3CDS | ENST00000540401 | ENST00000402685 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| 3UTR-3CDS | ENST00000540401 | ENST00000539469 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| 3UTR-3CDS | ENST00000540401 | ENST00000298919 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| In-frame | ENST00000306172 | ENST00000402685 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| In-frame | ENST00000306172 | ENST00000539469 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
| In-frame | ENST00000306172 | ENST00000298919 | CCDC91 | chr12 | 28637098 | + | PDZRN4 | chr12 | 41900258 | + |
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FusionProtFeatures for CCDC91_PDZRN4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCDC91 | PDZRN4 |