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Fusion gene ID: 5931 |
FusionGeneSummary for CCDC91_FAR2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCDC91_FAR2 | Fusion gene ID: 5931 | Hgene | Tgene | Gene symbol | CCDC91 | FAR2 | Gene ID | 55297 | 55711 |
| Gene name | coiled-coil domain containing 91 | fatty acyl-CoA reductase 2 | |
| Synonyms | HSD8|p56 | HEL-S-81|MLSTD1|SDR10E2 | |
| Cytomap | 12p11.22 | 12p11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | coiled-coil domain-containing protein 91GGA-binding partnerp56 accessory protein | fatty acyl-CoA reductase 2epididymis secretory protein Li 81male sterility domain-containing protein 1short chain dehydrogenase/reductase family 10E, member 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q7Z6B0 | Q96K12 | |
| Ensembl transtripts involved in fusion gene | ENST00000539107, ENST00000545336, ENST00000381256, ENST00000381259, ENST00000540401, ENST00000306172, | ENST00000536681, ENST00000549080, ENST00000182377, ENST00000547116, | |
| Fusion gene scores | * DoF score | 11 X 8 X 7=616 | 3 X 2 X 3=18 |
| # samples | 11 | 3 | |
| ** MAII score | log2(11/616*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CCDC91 [Title/Abstract] AND FAR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FAR2 | GO:0035336 | long-chain fatty-acyl-CoA metabolic process | 15220348 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-HT-7873-01B | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000539107 | ENST00000536681 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| 5CDS-intron | ENST00000539107 | ENST00000549080 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| 5CDS-5UTR | ENST00000539107 | ENST00000182377 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| 5CDS-intron | ENST00000539107 | ENST00000547116 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| 5CDS-5UTR | ENST00000545336 | ENST00000536681 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| 5CDS-intron | ENST00000545336 | ENST00000549080 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| 5CDS-5UTR | ENST00000545336 | ENST00000182377 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| 5CDS-intron | ENST00000545336 | ENST00000547116 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| 5CDS-5UTR | ENST00000381256 | ENST00000536681 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| 5CDS-intron | ENST00000381256 | ENST00000549080 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| 5CDS-5UTR | ENST00000381256 | ENST00000182377 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| 5CDS-intron | ENST00000381256 | ENST00000547116 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| 5CDS-5UTR | ENST00000381259 | ENST00000536681 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| 5CDS-intron | ENST00000381259 | ENST00000549080 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| 5CDS-5UTR | ENST00000381259 | ENST00000182377 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| 5CDS-intron | ENST00000381259 | ENST00000547116 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| intron-5UTR | ENST00000540401 | ENST00000536681 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| intron-intron | ENST00000540401 | ENST00000549080 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| intron-5UTR | ENST00000540401 | ENST00000182377 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| intron-intron | ENST00000540401 | ENST00000547116 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| intron-5UTR | ENST00000306172 | ENST00000536681 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| intron-intron | ENST00000306172 | ENST00000549080 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| intron-5UTR | ENST00000306172 | ENST00000182377 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
| intron-intron | ENST00000306172 | ENST00000547116 | CCDC91 | chr12 | 28412375 | + | FAR2 | chr12 | 29423345 | + |
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FusionProtFeatures for CCDC91_FAR2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCDC91 | FAR2 |