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Fusion gene ID: 5864 |
FusionGeneSummary for CCDC50_TBC1D5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCDC50_TBC1D5 | Fusion gene ID: 5864 | Hgene | Tgene | Gene symbol | CCDC50 | TBC1D5 | Gene ID | 152137 | 9779 |
| Gene name | coiled-coil domain containing 50 | TBC1 domain family member 5 | |
| Synonyms | C3orf6|DFNA44|YMER | - | |
| Cytomap | 3q28 | 3p24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | coiled-coil domain-containing protein 50protein Ymer | TBC1 domain family member 5 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IVM0 | Q92609 | |
| Ensembl transtripts involved in fusion gene | ENST00000392455, ENST00000392456, | ENST00000414318, ENST00000253692, ENST00000429383, ENST00000446818, ENST00000429924, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 7 X 7 X 5=245 |
| # samples | 5 | 7 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CCDC50 [Title/Abstract] AND TBC1D5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TBC1D5 | GO:0006914 | autophagy | 22354992 |
| Tgene | TBC1D5 | GO:0042594 | response to starvation | 22354992 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | MESO | TCGA-XT-AASU-01A | CCDC50 | chr3 | 191087825 | + | TBC1D5 | chr3 | 17665405 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000392455 | ENST00000414318 | CCDC50 | chr3 | 191087825 | + | TBC1D5 | chr3 | 17665405 | - |
| 5CDS-5UTR | ENST00000392455 | ENST00000253692 | CCDC50 | chr3 | 191087825 | + | TBC1D5 | chr3 | 17665405 | - |
| 5CDS-intron | ENST00000392455 | ENST00000429383 | CCDC50 | chr3 | 191087825 | + | TBC1D5 | chr3 | 17665405 | - |
| 5CDS-5UTR | ENST00000392455 | ENST00000446818 | CCDC50 | chr3 | 191087825 | + | TBC1D5 | chr3 | 17665405 | - |
| 5CDS-intron | ENST00000392455 | ENST00000429924 | CCDC50 | chr3 | 191087825 | + | TBC1D5 | chr3 | 17665405 | - |
| 5CDS-intron | ENST00000392456 | ENST00000414318 | CCDC50 | chr3 | 191087825 | + | TBC1D5 | chr3 | 17665405 | - |
| 5CDS-5UTR | ENST00000392456 | ENST00000253692 | CCDC50 | chr3 | 191087825 | + | TBC1D5 | chr3 | 17665405 | - |
| 5CDS-intron | ENST00000392456 | ENST00000429383 | CCDC50 | chr3 | 191087825 | + | TBC1D5 | chr3 | 17665405 | - |
| 5CDS-5UTR | ENST00000392456 | ENST00000446818 | CCDC50 | chr3 | 191087825 | + | TBC1D5 | chr3 | 17665405 | - |
| 5CDS-intron | ENST00000392456 | ENST00000429924 | CCDC50 | chr3 | 191087825 | + | TBC1D5 | chr3 | 17665405 | - |
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FusionProtFeatures for CCDC50_TBC1D5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCDC50 | TBC1D5 |