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Fusion gene ID: 5840 |
FusionGeneSummary for CCDC28B_PLEKHG1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCDC28B_PLEKHG1 | Fusion gene ID: 5840 | Hgene | Tgene | Gene symbol | CCDC28B | PLEKHG1 | Gene ID | 79140 | 57480 |
| Gene name | coiled-coil domain containing 28B | pleckstrin homology and RhoGEF domain containing G1 | |
| Synonyms | - | ARHGEF41 | |
| Cytomap | 1p35.2 | 6q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | coiled-coil domain-containing protein 28B | pleckstrin homology domain-containing family G member 1pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9BUN5 | Q9ULL1 | |
| Ensembl transtripts involved in fusion gene | ENST00000373602, ENST00000421922, ENST00000483009, | ENST00000367328, ENST00000358517, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 8 X 4=224 |
| # samples | 1 | 8 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CCDC28B [Title/Abstract] AND PLEKHG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA344455 | CCDC28B | chr1 | 32670632 | - | PLEKHG1 | chr6 | 151003671 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000373602 | ENST00000367328 | CCDC28B | chr1 | 32670632 | - | PLEKHG1 | chr6 | 151003671 | + |
| intron-intron | ENST00000373602 | ENST00000358517 | CCDC28B | chr1 | 32670632 | - | PLEKHG1 | chr6 | 151003671 | + |
| 3UTR-intron | ENST00000421922 | ENST00000367328 | CCDC28B | chr1 | 32670632 | - | PLEKHG1 | chr6 | 151003671 | + |
| 3UTR-intron | ENST00000421922 | ENST00000358517 | CCDC28B | chr1 | 32670632 | - | PLEKHG1 | chr6 | 151003671 | + |
| intron-intron | ENST00000483009 | ENST00000367328 | CCDC28B | chr1 | 32670632 | - | PLEKHG1 | chr6 | 151003671 | + |
| intron-intron | ENST00000483009 | ENST00000358517 | CCDC28B | chr1 | 32670632 | - | PLEKHG1 | chr6 | 151003671 | + |
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FusionProtFeatures for CCDC28B_PLEKHG1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCDC28B | PLEKHG1 |