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Fusion gene ID: 5692 |
FusionGeneSummary for CBL_PHLDB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CBL_PHLDB1 | Fusion gene ID: 5692 | Hgene | Tgene | Gene symbol | CBL | PHLDB1 | Gene ID | 867 | 23187 |
| Gene name | Cbl proto-oncogene | pleckstrin homology like domain family B member 1 | |
| Synonyms | C-CBL|CBL2|FRA11B|NSLL|RNF55 | LL5A | |
| Cytomap | 11q23.3 | 11q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase CBLCas-Br-M (murine) ecotropic retroviral transforming sequenceCbl proto-oncogene, E3 ubiquitin protein ligaseRING finger protein 55RING-type E3 ubiquitin transferase CBLcasitas B-lineage lymphoma proto-oncogenefragile si | pleckstrin homology-like domain family B member 1LL5alphapleckstrin homology-like domain family B member 1 variant 3pleckstrin homology-like domain family B member 1 variant 4protein LL5-alpha | |
| Modification date | 20180523 | 20180520 | |
| UniProtAcc | P22681 | Q86UU1 | |
| Ensembl transtripts involved in fusion gene | ENST00000264033, | ENST00000361417, ENST00000356063, ENST00000534672, ENST00000527898, ENST00000524713, | |
| Fusion gene scores | * DoF score | 10 X 7 X 7=490 | 4 X 5 X 3=60 |
| # samples | 11 | 6 | |
| ** MAII score | log2(11/490*10)=-2.15527822547791 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/60*10)=0 | |
| Context | PubMed: CBL [Title/Abstract] AND PHLDB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-GM-A2DD-01A | CBL | chr11 | 119156276 | + | PHLDB1 | chr11 | 118514518 | + |
| TCGA | RV | ESCA | TCGA-L5-A4OQ-01A | CBL | chr11 | 119077322 | + | PHLDB1 | chr11 | 118484531 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000264033 | ENST00000361417 | CBL | chr11 | 119156276 | + | PHLDB1 | chr11 | 118514518 | + |
| In-frame | ENST00000264033 | ENST00000356063 | CBL | chr11 | 119156276 | + | PHLDB1 | chr11 | 118514518 | + |
| 5CDS-3UTR | ENST00000264033 | ENST00000534672 | CBL | chr11 | 119156276 | + | PHLDB1 | chr11 | 118514518 | + |
| 5CDS-5UTR | ENST00000264033 | ENST00000527898 | CBL | chr11 | 119156276 | + | PHLDB1 | chr11 | 118514518 | + |
| 5CDS-5UTR | ENST00000264033 | ENST00000524713 | CBL | chr11 | 119156276 | + | PHLDB1 | chr11 | 118514518 | + |
| 5CDS-5UTR | ENST00000264033 | ENST00000361417 | CBL | chr11 | 119077322 | + | PHLDB1 | chr11 | 118484531 | + |
| 5CDS-5UTR | ENST00000264033 | ENST00000356063 | CBL | chr11 | 119077322 | + | PHLDB1 | chr11 | 118484531 | + |
| 5CDS-intron | ENST00000264033 | ENST00000534672 | CBL | chr11 | 119077322 | + | PHLDB1 | chr11 | 118484531 | + |
| 5CDS-intron | ENST00000264033 | ENST00000527898 | CBL | chr11 | 119077322 | + | PHLDB1 | chr11 | 118484531 | + |
| 5CDS-intron | ENST00000264033 | ENST00000524713 | CBL | chr11 | 119077322 | + | PHLDB1 | chr11 | 118484531 | + |
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FusionProtFeatures for CBL_PHLDB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CBL | PHLDB1 |