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Fusion gene ID: 5678 |
FusionGeneSummary for CBFB_TIGD7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CBFB_TIGD7 | Fusion gene ID: 5678 | Hgene | Tgene | Gene symbol | CBFB | TIGD7 | Gene ID | 865 | 91151 |
| Gene name | core-binding factor subunit beta | tigger transposable element derived 7 | |
| Synonyms | PEBP2B | Sancho | |
| Cytomap | 16q22.1 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | core-binding factor subunit betaCBF-betaPEA2-betaPEBP2-betaSL3-3 enhancer factor 1 beta subunitSL3-3 enhancer factor 1 subunit betaSL3/AKV core-binding factor beta subunitcore-binding factor beta subunitpolyomavirus enhancer binding protein 2, bet | tigger transposable element-derived protein 7 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q13951 | Q6NT04 | |
| Ensembl transtripts involved in fusion gene | ENST00000561924, ENST00000290858, ENST00000412916, ENST00000568858, | ENST00000396862, ENST00000268674, ENST00000574598, | |
| Fusion gene scores | * DoF score | 14 X 14 X 9=1764 | 1 X 1 X 1=1 |
| # samples | 26 | 1 | |
| ** MAII score | log2(26/1764*10)=-2.76226703252907 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CBFB [Title/Abstract] AND TIGD7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A1B6-01A | CBFB | chr16 | 67116211 | + | TIGD7 | chr16 | 3352009 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000561924 | ENST00000396862 | CBFB | chr16 | 67116211 | + | TIGD7 | chr16 | 3352009 | - |
| 5CDS-intron | ENST00000561924 | ENST00000268674 | CBFB | chr16 | 67116211 | + | TIGD7 | chr16 | 3352009 | - |
| 5CDS-5UTR | ENST00000561924 | ENST00000574598 | CBFB | chr16 | 67116211 | + | TIGD7 | chr16 | 3352009 | - |
| 5CDS-5UTR | ENST00000290858 | ENST00000396862 | CBFB | chr16 | 67116211 | + | TIGD7 | chr16 | 3352009 | - |
| 5CDS-intron | ENST00000290858 | ENST00000268674 | CBFB | chr16 | 67116211 | + | TIGD7 | chr16 | 3352009 | - |
| 5CDS-5UTR | ENST00000290858 | ENST00000574598 | CBFB | chr16 | 67116211 | + | TIGD7 | chr16 | 3352009 | - |
| 5CDS-5UTR | ENST00000412916 | ENST00000396862 | CBFB | chr16 | 67116211 | + | TIGD7 | chr16 | 3352009 | - |
| 5CDS-intron | ENST00000412916 | ENST00000268674 | CBFB | chr16 | 67116211 | + | TIGD7 | chr16 | 3352009 | - |
| 5CDS-5UTR | ENST00000412916 | ENST00000574598 | CBFB | chr16 | 67116211 | + | TIGD7 | chr16 | 3352009 | - |
| intron-5UTR | ENST00000568858 | ENST00000396862 | CBFB | chr16 | 67116211 | + | TIGD7 | chr16 | 3352009 | - |
| intron-intron | ENST00000568858 | ENST00000268674 | CBFB | chr16 | 67116211 | + | TIGD7 | chr16 | 3352009 | - |
| intron-5UTR | ENST00000568858 | ENST00000574598 | CBFB | chr16 | 67116211 | + | TIGD7 | chr16 | 3352009 | - |
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FusionProtFeatures for CBFB_TIGD7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CBFB | TIGD7 |