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Fusion gene ID: 5670 |
FusionGeneSummary for CBFB_GSE1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CBFB_GSE1 | Fusion gene ID: 5670 | Hgene | Tgene | Gene symbol | CBFB | GSE1 | Gene ID | 865 | 23199 |
| Gene name | core-binding factor subunit beta | Gse1 coiled-coil protein | |
| Synonyms | PEBP2B | CRHSP24|KIAA0182 | |
| Cytomap | 16q22.1 | 16q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | core-binding factor subunit betaCBF-betaPEA2-betaPEBP2-betaSL3-3 enhancer factor 1 beta subunitSL3-3 enhancer factor 1 subunit betaSL3/AKV core-binding factor beta subunitcore-binding factor beta subunitpolyomavirus enhancer binding protein 2, bet | genetic suppressor element 1CTC-786C10.1Gse1 coiled-coil protein homolog | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q13951 | Q14687 | |
| Ensembl transtripts involved in fusion gene | ENST00000561924, ENST00000290858, ENST00000412916, ENST00000568858, | ENST00000405402, ENST00000253458, ENST00000393243, ENST00000471070, | |
| Fusion gene scores | * DoF score | 14 X 14 X 9=1764 | 7 X 7 X 5=245 |
| # samples | 26 | 7 | |
| ** MAII score | log2(26/1764*10)=-2.76226703252907 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CBFB [Title/Abstract] AND GSE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-23-2084-01A | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000561924 | ENST00000405402 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| 5CDS-intron | ENST00000561924 | ENST00000253458 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| 5CDS-intron | ENST00000561924 | ENST00000393243 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| 5CDS-intron | ENST00000561924 | ENST00000471070 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| 5CDS-intron | ENST00000290858 | ENST00000405402 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| 5CDS-intron | ENST00000290858 | ENST00000253458 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| 5CDS-intron | ENST00000290858 | ENST00000393243 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| 5CDS-intron | ENST00000290858 | ENST00000471070 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| 5CDS-intron | ENST00000412916 | ENST00000405402 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| 5CDS-intron | ENST00000412916 | ENST00000253458 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| 5CDS-intron | ENST00000412916 | ENST00000393243 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| 5CDS-intron | ENST00000412916 | ENST00000471070 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| intron-intron | ENST00000568858 | ENST00000405402 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| intron-intron | ENST00000568858 | ENST00000253458 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| intron-intron | ENST00000568858 | ENST00000393243 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
| intron-intron | ENST00000568858 | ENST00000471070 | CBFB | chr16 | 67116211 | + | GSE1 | chr16 | 85205195 | + |
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FusionProtFeatures for CBFB_GSE1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CBFB | GSE1 |