|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 561 |
FusionGeneSummary for ACTG1_TADA2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACTG1_TADA2B | Fusion gene ID: 561 | Hgene | Tgene | Gene symbol | ACTG1 | TADA2B | Gene ID | 71 | 93624 |
| Gene name | actin gamma 1 | transcriptional adaptor 2B | |
| Synonyms | ACT|ACTG|DFNA20|DFNA26|HEL-176 | ADA2(beta)|ADA2B | |
| Cytomap | 17q25.3 | 4p16.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | actin, cytoplasmic 2cytoskeletal gamma-actinepididymis luminal protein 176 | transcriptional adapter 2-betaADA2-betaADA2-like protein betatranscriptional adaptor 2 (ADA2 homolog, yeast)-beta | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P63261 | Q86TJ2 | |
| Ensembl transtripts involved in fusion gene | ENST00000331925, ENST00000573283, ENST00000575842, ENST00000575087, | ENST00000310074, ENST00000512388, ENST00000515646, | |
| Fusion gene scores | * DoF score | 25 X 19 X 11=5225 | 2 X 2 X 2=8 |
| # samples | 34 | 2 | |
| ** MAII score | log2(34/5225*10)=-3.94182438571791 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ACTG1 [Title/Abstract] AND TADA2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI040029 | ACTG1 | chr17 | 79479086 | + | TADA2B | chr4 | 7057993 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000331925 | ENST00000310074 | ACTG1 | chr17 | 79479086 | + | TADA2B | chr4 | 7057993 | + |
| intron-intron | ENST00000331925 | ENST00000512388 | ACTG1 | chr17 | 79479086 | + | TADA2B | chr4 | 7057993 | + |
| intron-3UTR | ENST00000331925 | ENST00000515646 | ACTG1 | chr17 | 79479086 | + | TADA2B | chr4 | 7057993 | + |
| intron-3UTR | ENST00000573283 | ENST00000310074 | ACTG1 | chr17 | 79479086 | + | TADA2B | chr4 | 7057993 | + |
| intron-intron | ENST00000573283 | ENST00000512388 | ACTG1 | chr17 | 79479086 | + | TADA2B | chr4 | 7057993 | + |
| intron-3UTR | ENST00000573283 | ENST00000515646 | ACTG1 | chr17 | 79479086 | + | TADA2B | chr4 | 7057993 | + |
| intron-3UTR | ENST00000575842 | ENST00000310074 | ACTG1 | chr17 | 79479086 | + | TADA2B | chr4 | 7057993 | + |
| intron-intron | ENST00000575842 | ENST00000512388 | ACTG1 | chr17 | 79479086 | + | TADA2B | chr4 | 7057993 | + |
| intron-3UTR | ENST00000575842 | ENST00000515646 | ACTG1 | chr17 | 79479086 | + | TADA2B | chr4 | 7057993 | + |
| intron-3UTR | ENST00000575087 | ENST00000310074 | ACTG1 | chr17 | 79479086 | + | TADA2B | chr4 | 7057993 | + |
| intron-intron | ENST00000575087 | ENST00000512388 | ACTG1 | chr17 | 79479086 | + | TADA2B | chr4 | 7057993 | + |
| intron-3UTR | ENST00000575087 | ENST00000515646 | ACTG1 | chr17 | 79479086 | + | TADA2B | chr4 | 7057993 | + |
Top |
FusionProtFeatures for ACTG1_TADA2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACTG1 | TADA2B |