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Fusion gene ID: 5549 |
FusionGeneSummary for CARS2_ATP11A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CARS2_ATP11A | Fusion gene ID: 5549 | Hgene | Tgene | Gene symbol | CARS2 | ATP11A | Gene ID | 79587 | 23250 |
| Gene name | cysteinyl-tRNA synthetase 2, mitochondrial | ATPase phospholipid transporting 11A | |
| Synonyms | COXPD27|cysRS | ATPIH|ATPIS | |
| Cytomap | 13q34 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable cysteine--tRNA ligase, mitochondrialcysteine tRNA ligase 2, mitochondrial (putative)cysteinyl-tRNA synthetase 2, mitochondrial (putative) | probable phospholipid-transporting ATPase IHATPase, class VI, type 11AP4-ATPase flippase complex alpha subunit ATP11Aphospholipid-translocating ATPasepotential phospholipid-transporting ATPase IH | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9HA77 | P98196 | |
| Ensembl transtripts involved in fusion gene | ENST00000257347, ENST00000535398, | ENST00000283558, ENST00000375630, ENST00000487903, ENST00000375645, ENST00000419448, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 11 X 10 X 4=440 |
| # samples | 1 | 13 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(13/440*10)=-1.7589919004962 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CARS2 [Title/Abstract] AND ATP11A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-69-7979-01A | CARS2 | chr13 | 111365484 | - | ATP11A | chr13 | 113508593 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000257347 | ENST00000283558 | CARS2 | chr13 | 111365484 | - | ATP11A | chr13 | 113508593 | + |
| intron-3CDS | ENST00000257347 | ENST00000375630 | CARS2 | chr13 | 111365484 | - | ATP11A | chr13 | 113508593 | + |
| intron-3CDS | ENST00000257347 | ENST00000487903 | CARS2 | chr13 | 111365484 | - | ATP11A | chr13 | 113508593 | + |
| intron-3CDS | ENST00000257347 | ENST00000375645 | CARS2 | chr13 | 111365484 | - | ATP11A | chr13 | 113508593 | + |
| intron-intron | ENST00000257347 | ENST00000419448 | CARS2 | chr13 | 111365484 | - | ATP11A | chr13 | 113508593 | + |
| 5UTR-3CDS | ENST00000535398 | ENST00000283558 | CARS2 | chr13 | 111365484 | - | ATP11A | chr13 | 113508593 | + |
| 5UTR-3CDS | ENST00000535398 | ENST00000375630 | CARS2 | chr13 | 111365484 | - | ATP11A | chr13 | 113508593 | + |
| 5UTR-3CDS | ENST00000535398 | ENST00000487903 | CARS2 | chr13 | 111365484 | - | ATP11A | chr13 | 113508593 | + |
| 5UTR-3CDS | ENST00000535398 | ENST00000375645 | CARS2 | chr13 | 111365484 | - | ATP11A | chr13 | 113508593 | + |
| 5UTR-intron | ENST00000535398 | ENST00000419448 | CARS2 | chr13 | 111365484 | - | ATP11A | chr13 | 113508593 | + |
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FusionProtFeatures for CARS2_ATP11A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CARS2 | ATP11A |