|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 5524 |
FusionGeneSummary for CARD10_CAMK2N1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CARD10_CAMK2N1 | Fusion gene ID: 5524 | Hgene | Tgene | Gene symbol | CARD10 | CAMK2N1 | Gene ID | 29775 | 55450 |
| Gene name | caspase recruitment domain family member 10 | calcium/calmodulin dependent protein kinase II inhibitor 1 | |
| Synonyms | BIMP1|CARMA3 | PRO1489 | |
| Cytomap | 22q13.1 | 1p36.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | caspase recruitment domain-containing protein 10Bcl10 binding protein and activator of NFKBCARD-containing MAGUK 3 proteinCARD-containing MAGUK protein 3carma 3 | calcium/calmodulin-dependent protein kinase II inhibitor 1CaMKIINalphacaMKII inhibitory protein alphacaMKIIN-alpha | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9BWT7 | Q7Z7J9 | |
| Ensembl transtripts involved in fusion gene | ENST00000403299, ENST00000406271, ENST00000251973, ENST00000494166, | ENST00000375078, ENST00000489020, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 3 X 3 X 1=9 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CARD10 [Title/Abstract] AND CAMK2N1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CARD10 | GO:0007250 | activation of NF-kappaB-inducing kinase activity | 11259443 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA316883 | CARD10 | chr22 | 37903857 | - | CAMK2N1 | chr1 | 20809975 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000403299 | ENST00000375078 | CARD10 | chr22 | 37903857 | - | CAMK2N1 | chr1 | 20809975 | - |
| intron-5UTR | ENST00000403299 | ENST00000489020 | CARD10 | chr22 | 37903857 | - | CAMK2N1 | chr1 | 20809975 | - |
| intron-3UTR | ENST00000406271 | ENST00000375078 | CARD10 | chr22 | 37903857 | - | CAMK2N1 | chr1 | 20809975 | - |
| intron-5UTR | ENST00000406271 | ENST00000489020 | CARD10 | chr22 | 37903857 | - | CAMK2N1 | chr1 | 20809975 | - |
| intron-3UTR | ENST00000251973 | ENST00000375078 | CARD10 | chr22 | 37903857 | - | CAMK2N1 | chr1 | 20809975 | - |
| intron-5UTR | ENST00000251973 | ENST00000489020 | CARD10 | chr22 | 37903857 | - | CAMK2N1 | chr1 | 20809975 | - |
| intron-3UTR | ENST00000494166 | ENST00000375078 | CARD10 | chr22 | 37903857 | - | CAMK2N1 | chr1 | 20809975 | - |
| intron-5UTR | ENST00000494166 | ENST00000489020 | CARD10 | chr22 | 37903857 | - | CAMK2N1 | chr1 | 20809975 | - |
Top |
FusionProtFeatures for CARD10_CAMK2N1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CARD10 | CAMK2N1 |