|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 5497 |
FusionGeneSummary for CAPS2_GLIPR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CAPS2_GLIPR1 | Fusion gene ID: 5497 | Hgene | Tgene | Gene symbol | CAPS2 | GLIPR1 | Gene ID | 93664 | 11010 |
| Gene name | calcium dependent secretion activator 2 | GLI pathogenesis related 1 | |
| Synonyms | CAPS2 | CRISP7|GLIPR|RTVP1 | |
| Cytomap | 7q31.32 | 12q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calcium-dependent secretion activator 2CAPS-2Ca++-dependent secretion activator 2Ca2+ dependent secretion activator 2Ca2+-dependent activator protein for secretion 2calcium-dependent activator protein for secretion 2 | glioma pathogenesis-related protein 1GLI pathogenesis-related 1 (glioma)gliPR 1protein RTVP-1related to testis-specific, vespid, and pathogenesis proteins 1testes-specific vespid and pathogenesis protein 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9BXY5 | P48060 | |
| Ensembl transtripts involved in fusion gene | ENST00000442339, ENST00000409004, ENST00000409799, ENST00000409445, ENST00000393284, | ENST00000266659, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CAPS2 [Title/Abstract] AND GLIPR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-EW-A1P6-01A | CAPS2 | chr12 | 75784102 | - | GLIPR1 | chr12 | 75875614 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000442339 | ENST00000266659 | CAPS2 | chr12 | 75784102 | - | GLIPR1 | chr12 | 75875614 | + |
| intron-3CDS | ENST00000409004 | ENST00000266659 | CAPS2 | chr12 | 75784102 | - | GLIPR1 | chr12 | 75875614 | + |
| intron-3CDS | ENST00000409799 | ENST00000266659 | CAPS2 | chr12 | 75784102 | - | GLIPR1 | chr12 | 75875614 | + |
| intron-3CDS | ENST00000409445 | ENST00000266659 | CAPS2 | chr12 | 75784102 | - | GLIPR1 | chr12 | 75875614 | + |
| intron-3CDS | ENST00000393284 | ENST00000266659 | CAPS2 | chr12 | 75784102 | - | GLIPR1 | chr12 | 75875614 | + |
Top |
FusionProtFeatures for CAPS2_GLIPR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CAPS2 | GLIPR1 |