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Fusion gene ID: 5339 |
FusionGeneSummary for CAMK1D_ARL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CAMK1D_ARL3 | Fusion gene ID: 5339 | Hgene | Tgene | Gene symbol | CAMK1D | ARL3 | Gene ID | 57118 | 403 |
| Gene name | calcium/calmodulin dependent protein kinase ID | ADP ribosylation factor like GTPase 3 | |
| Synonyms | CKLiK|CaM-K1|CaMKID | ARFL3 | |
| Cytomap | 10p13 | 10q24.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI delta | ADP-ribosylation factor-like protein 3ADP-ribosylation factor-like 3ARF-like 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8IU85 | P36405 | |
| Ensembl transtripts involved in fusion gene | ENST00000378847, ENST00000487696, ENST00000378845, | ENST00000260746, | |
| Fusion gene scores | * DoF score | 10 X 10 X 6=600 | 6 X 4 X 5=120 |
| # samples | 14 | 7 | |
| ** MAII score | log2(14/600*10)=-2.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CAMK1D [Title/Abstract] AND ARL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CAMK1D | GO:0032793 | positive regulation of CREB transcription factor activity | 16324104 |
| Tgene | ARL3 | GO:0007264 | small GTPase mediated signal transduction | 22085962 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-44-3917-01A | CAMK1D | chr10 | 12833232 | + | ARL3 | chr10 | 104465246 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000378847 | ENST00000260746 | CAMK1D | chr10 | 12833232 | + | ARL3 | chr10 | 104465246 | - |
| intron-3CDS | ENST00000487696 | ENST00000260746 | CAMK1D | chr10 | 12833232 | + | ARL3 | chr10 | 104465246 | - |
| Frame-shift | ENST00000378845 | ENST00000260746 | CAMK1D | chr10 | 12833232 | + | ARL3 | chr10 | 104465246 | - |
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FusionProtFeatures for CAMK1D_ARL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CAMK1D | ARL3 |