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Fusion gene ID: 5308 |
FusionGeneSummary for CALM1_UNC5CL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CALM1_UNC5CL | Fusion gene ID: 5308 | Hgene | Tgene | Gene symbol | CALM1 | UNC5CL | Gene ID | 801 | 222643 |
| Gene name | calmodulin 1 | unc-5 family C-terminal like | |
| Synonyms | CALML2|CAMI|CPVT4|DD132|LQT14|PHKD|caM | MUXA|ZUD | |
| Cytomap | 14q32.11 | 6p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calmodulin-1calmodulin 1 (phosphorylase kinase, delta)phosphorylase kinase subunit deltaphosphorylase kinase, delta subunitprepro-calmodulin 1 | UNC5C-like proteinZU5 and death domain containingprotein unc-5 homolog C-likeunc-5 homolog C-like | |
| Modification date | 20180529 | 20180519 | |
| UniProtAcc | Q8IV45 | ||
| Ensembl transtripts involved in fusion gene | ENST00000356978, ENST00000447653, ENST00000555132, ENST00000553542, ENST00000544280, | ENST00000244565, ENST00000373164, ENST00000470102, | |
| Fusion gene scores | * DoF score | 10 X 10 X 2=200 | 1 X 1 X 1=1 |
| # samples | 21 | 1 | |
| ** MAII score | log2(21/200*10)=0.070389327891398 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CALM1 [Title/Abstract] AND UNC5CL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CALM1 | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 20226167 |
| Hgene | CALM1 | GO:0030801 | positive regulation of cyclic nucleotide metabolic process | 8631777 |
| Hgene | CALM1 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 8631777 |
| Hgene | CALM1 | GO:0035307 | positive regulation of protein dephosphorylation | 8631777 |
| Hgene | CALM1 | GO:0051343 | positive regulation of cyclic-nucleotide phosphodiesterase activity | 8631777 |
| Hgene | CALM1 | GO:0051592 | response to calcium ion | 7607248 |
| Hgene | CALM1 | GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 22067155 |
| Hgene | CALM1 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 26164367 |
| Hgene | CALM1 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 20226167 |
| Tgene | UNC5CL | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 22158417 |
| Tgene | UNC5CL | GO:0046330 | positive regulation of JNK cascade | 22158417 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA496229 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000356978 | ENST00000244565 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
| 3UTR-intron | ENST00000356978 | ENST00000373164 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
| 3UTR-intron | ENST00000356978 | ENST00000470102 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
| intron-intron | ENST00000447653 | ENST00000244565 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
| intron-intron | ENST00000447653 | ENST00000373164 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
| intron-intron | ENST00000447653 | ENST00000470102 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
| intron-intron | ENST00000555132 | ENST00000244565 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
| intron-intron | ENST00000555132 | ENST00000373164 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
| intron-intron | ENST00000555132 | ENST00000470102 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
| intron-intron | ENST00000553542 | ENST00000244565 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
| intron-intron | ENST00000553542 | ENST00000373164 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
| intron-intron | ENST00000553542 | ENST00000470102 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
| intron-intron | ENST00000544280 | ENST00000244565 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
| intron-intron | ENST00000544280 | ENST00000373164 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
| intron-intron | ENST00000544280 | ENST00000470102 | CALM1 | chr14 | 90872653 | + | UNC5CL | chr6 | 41029533 | + |
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FusionProtFeatures for CALM1_UNC5CL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CALM1 | UNC5CL |