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Fusion gene ID: 5268 |
FusionGeneSummary for CADPS2_DNAH11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CADPS2_DNAH11 | Fusion gene ID: 5268 | Hgene | Tgene | Gene symbol | CADPS2 | DNAH11 | Gene ID | 93664 | 8701 |
| Gene name | calcium dependent secretion activator 2 | dynein axonemal heavy chain 11 | |
| Synonyms | CAPS2 | CILD7|DNAHBL|DNAHC11|DNHBL|DPL11 | |
| Cytomap | 7q31.32 | 7p15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calcium-dependent secretion activator 2CAPS-2Ca++-dependent secretion activator 2Ca2+ dependent secretion activator 2Ca2+-dependent activator protein for secretion 2calcium-dependent activator protein for secretion 2 | dynein heavy chain 11, axonemalaxonemal beta dynein heavy chain 11axonemal dynein heavy chain 11ciliary dynein heavy chain 11dynein, axonemal, heavy polypeptide 11dynein, ciliary, heavy chain 11 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q86UW7 | Q96DT5 | |
| Ensembl transtripts involved in fusion gene | ENST00000313070, ENST00000334010, ENST00000412584, ENST00000449022, ENST00000476131, | ENST00000409508, ENST00000328843, ENST00000465593, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 4 X 4 X 4=64 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CADPS2 [Title/Abstract] AND DNAH11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-7330-01A | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000313070 | ENST00000409508 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
| Frame-shift | ENST00000313070 | ENST00000328843 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
| 5CDS-intron | ENST00000313070 | ENST00000465593 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
| Frame-shift | ENST00000334010 | ENST00000409508 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
| Frame-shift | ENST00000334010 | ENST00000328843 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
| 5CDS-intron | ENST00000334010 | ENST00000465593 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
| Frame-shift | ENST00000412584 | ENST00000409508 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
| Frame-shift | ENST00000412584 | ENST00000328843 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
| 5CDS-intron | ENST00000412584 | ENST00000465593 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
| Frame-shift | ENST00000449022 | ENST00000409508 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
| Frame-shift | ENST00000449022 | ENST00000328843 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
| 5CDS-intron | ENST00000449022 | ENST00000465593 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
| intron-3CDS | ENST00000476131 | ENST00000409508 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
| intron-3CDS | ENST00000476131 | ENST00000328843 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
| intron-intron | ENST00000476131 | ENST00000465593 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
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FusionProtFeatures for CADPS2_DNAH11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CADPS2 | DNAH11 |