FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 5262

FusionGeneSummary for CADM3_CALM3

check button Fusion gene summary
Fusion gene informationFusion gene name: CADM3_CALM3
Fusion gene ID: 5262
HgeneTgene
Gene symbol

CADM3

CALM3

Gene ID

57863

808

Gene namecell adhesion molecule 3calmodulin 3
SynonymsBIgR|IGSF4B|NECL1|Necl-1|TSLL1|synCAM3CaM|CaMIII|HEL-S-72|PHKD|PHKD3
Cytomap

1q23.2

19q13.32

Type of geneprotein-codingprotein-coding
Descriptioncell adhesion molecule 3TSLC1-like 1brain immunoglobulin receptordendritic cell nectin-like protein 1 short isoformimmunoglobulin superfamily member 4Bsynaptic cell adhesion molecule 3calmodulin-3epididymis secretory protein Li 72phosphorylase kinase subunit deltaprepro-calmodulin 3
Modification date2018052220180523
UniProtAcc

Q8N126

Ensembl transtripts involved in fusion geneENST00000368124, ENST00000368125, 
ENST00000497636, 		ENST00000391918, 
ENST00000291295, ENST00000597743, 
ENST00000477244, ENST00000598871, 
ENST00000594523, ENST00000599839, 
ENST00000596362, 
Fusion gene scores* DoF score2 X 2 X 1=48 X 9 X 3=216
# samples 210
** MAII scorelog2(2/4*10)=2.32192809488736log2(10/216*10)=-1.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CADM3 [Title/Abstract] AND CALM3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCALM3

GO:0010880

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

20226167

TgeneCALM3

GO:0030801

positive regulation of cyclic nucleotide metabolic process

8631777

TgeneCALM3

GO:0032516

positive regulation of phosphoprotein phosphatase activity

8631777

TgeneCALM3

GO:0035307

positive regulation of protein dephosphorylation

8631777

TgeneCALM3

GO:0051343

positive regulation of cyclic-nucleotide phosphodiesterase activity

8631777

TgeneCALM3

GO:0051592

response to calcium ion

7607248

TgeneCALM3

GO:0060316

positive regulation of ryanodine-sensitive calcium-release channel activity

20226167


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF947810CADM3chr1

159172123

-CALM3chr19

47113040

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000368124ENST00000391918CADM3chr1

159172123

-CALM3chr19

47113040

+
intron-3UTRENST00000368124ENST00000291295CADM3chr1

159172123

-CALM3chr19

47113040

+
intron-intronENST00000368124ENST00000597743CADM3chr1

159172123

-CALM3chr19

47113040

+
intron-intronENST00000368124ENST00000477244CADM3chr1

159172123

-CALM3chr19

47113040

+
intron-intronENST00000368124ENST00000598871CADM3chr1

159172123

-CALM3chr19

47113040

+
intron-intronENST00000368124ENST00000594523CADM3chr1

159172123

-CALM3chr19

47113040

+
intron-3UTRENST00000368124ENST00000599839CADM3chr1

159172123

-CALM3chr19

47113040

+
intron-intronENST00000368124ENST00000596362CADM3chr1

159172123

-CALM3chr19

47113040

+
3UTR-intronENST00000368125ENST00000391918CADM3chr1

159172123

-CALM3chr19

47113040

+
3UTR-3UTRENST00000368125ENST00000291295CADM3chr1

159172123

-CALM3chr19

47113040

+
3UTR-intronENST00000368125ENST00000597743CADM3chr1

159172123

-CALM3chr19

47113040

+
3UTR-intronENST00000368125ENST00000477244CADM3chr1

159172123

-CALM3chr19

47113040

+
3UTR-intronENST00000368125ENST00000598871CADM3chr1

159172123

-CALM3chr19

47113040

+
3UTR-intronENST00000368125ENST00000594523CADM3chr1

159172123

-CALM3chr19

47113040

+
3UTR-3UTRENST00000368125ENST00000599839CADM3chr1

159172123

-CALM3chr19

47113040

+
3UTR-intronENST00000368125ENST00000596362CADM3chr1

159172123

-CALM3chr19

47113040

+
intron-intronENST00000497636ENST00000391918CADM3chr1

159172123

-CALM3chr19

47113040

+
intron-3UTRENST00000497636ENST00000291295CADM3chr1

159172123

-CALM3chr19

47113040

+
intron-intronENST00000497636ENST00000597743CADM3chr1

159172123

-CALM3chr19

47113040

+
intron-intronENST00000497636ENST00000477244CADM3chr1

159172123

-CALM3chr19

47113040

+
intron-intronENST00000497636ENST00000598871CADM3chr1

159172123

-CALM3chr19

47113040

+
intron-intronENST00000497636ENST00000594523CADM3chr1

159172123

-CALM3chr19

47113040

+
intron-3UTRENST00000497636ENST00000599839CADM3chr1

159172123

-CALM3chr19

47113040

+
intron-intronENST00000497636ENST00000596362CADM3chr1

159172123

-CALM3chr19

47113040

+

Top

FusionProtFeatures for CADM3_CALM3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CADM3

Q8N126

CALM3

Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4,NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulatestructure or function of cell-cell junctions (By similarity).{ECO:0000250}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CADM3_CALM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CADM3_CALM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CADM3_CALM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CADM3_CALM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource