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Fusion gene ID: 5246 |
FusionGeneSummary for CACUL1_CACUL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CACUL1_CACUL1 | Fusion gene ID: 5246 | Hgene | Tgene | Gene symbol | CACUL1 | CACUL1 | Gene ID | 143384 | 143384 |
| Gene name | CDK2 associated cullin domain 1 | CDK2 associated cullin domain 1 | |
| Synonyms | C10orf46|CAC1 | C10orf46|CAC1 | |
| Cytomap | 10q26.11 | 10q26.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CDK2-associated and cullin domain-containing protein 1Cdk-Associated Cullin1cullin | CDK2-associated and cullin domain-containing protein 1Cdk-Associated Cullin1cullin | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q86Y37 | Q86Y37 | |
| Ensembl transtripts involved in fusion gene | ENST00000544392, ENST00000369151, ENST00000340214, | ENST00000544392, ENST00000369151, ENST00000340214, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 3 X 4 X 2=24 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CACUL1 [Title/Abstract] AND CACUL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI829926 | CACUL1 | chr10 | 120514198 | + | CACUL1 | chr10 | 120443446 | + | ||
| ChiTaRS3.1 | BF530533 | CACUL1 | chr10 | 120442646 | + | CACUL1 | chr10 | 120442576 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000544392 | ENST00000544392 | CACUL1 | chr10 | 120514198 | + | CACUL1 | chr10 | 120443446 | + |
| intron-3UTR | ENST00000544392 | ENST00000369151 | CACUL1 | chr10 | 120514198 | + | CACUL1 | chr10 | 120443446 | + |
| intron-intron | ENST00000544392 | ENST00000340214 | CACUL1 | chr10 | 120514198 | + | CACUL1 | chr10 | 120443446 | + |
| intron-intron | ENST00000369151 | ENST00000544392 | CACUL1 | chr10 | 120514198 | + | CACUL1 | chr10 | 120443446 | + |
| intron-3UTR | ENST00000369151 | ENST00000369151 | CACUL1 | chr10 | 120514198 | + | CACUL1 | chr10 | 120443446 | + |
| intron-intron | ENST00000369151 | ENST00000340214 | CACUL1 | chr10 | 120514198 | + | CACUL1 | chr10 | 120443446 | + |
| intron-intron | ENST00000340214 | ENST00000544392 | CACUL1 | chr10 | 120514198 | + | CACUL1 | chr10 | 120443446 | + |
| intron-3UTR | ENST00000340214 | ENST00000369151 | CACUL1 | chr10 | 120514198 | + | CACUL1 | chr10 | 120443446 | + |
| intron-intron | ENST00000340214 | ENST00000340214 | CACUL1 | chr10 | 120514198 | + | CACUL1 | chr10 | 120443446 | + |
| intron-intron | ENST00000544392 | ENST00000544392 | CACUL1 | chr10 | 120442646 | + | CACUL1 | chr10 | 120442576 | - |
| intron-3UTR | ENST00000544392 | ENST00000369151 | CACUL1 | chr10 | 120442646 | + | CACUL1 | chr10 | 120442576 | - |
| intron-intron | ENST00000544392 | ENST00000340214 | CACUL1 | chr10 | 120442646 | + | CACUL1 | chr10 | 120442576 | - |
| intron-intron | ENST00000369151 | ENST00000544392 | CACUL1 | chr10 | 120442646 | + | CACUL1 | chr10 | 120442576 | - |
| intron-3UTR | ENST00000369151 | ENST00000369151 | CACUL1 | chr10 | 120442646 | + | CACUL1 | chr10 | 120442576 | - |
| intron-intron | ENST00000369151 | ENST00000340214 | CACUL1 | chr10 | 120442646 | + | CACUL1 | chr10 | 120442576 | - |
| intron-intron | ENST00000340214 | ENST00000544392 | CACUL1 | chr10 | 120442646 | + | CACUL1 | chr10 | 120442576 | - |
| intron-3UTR | ENST00000340214 | ENST00000369151 | CACUL1 | chr10 | 120442646 | + | CACUL1 | chr10 | 120442576 | - |
| intron-intron | ENST00000340214 | ENST00000340214 | CACUL1 | chr10 | 120442646 | + | CACUL1 | chr10 | 120442576 | - |
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FusionProtFeatures for CACUL1_CACUL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CACUL1 | CACUL1 |