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Fusion gene ID: 5230 |
FusionGeneSummary for CACNB1_LASP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CACNB1_LASP1 | Fusion gene ID: 5230 | Hgene | Tgene | Gene symbol | CACNB1 | LASP1 | Gene ID | 782 | 3927 |
| Gene name | calcium voltage-gated channel auxiliary subunit beta 1 | LIM and SH3 protein 1 | |
| Synonyms | CAB1|CACNLB1|CCHLB1 | Lasp-1|MLN50 | |
| Cytomap | 17q12 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | voltage-dependent L-type calcium channel subunit beta-1calcium channel voltage-dependent subunit beta 1calcium channel, L type, beta 1 polypeptidecalcium channel, voltage-dependent, beta 1 subunitdihydropyridine-sensitive L-type, calcium channel beta- | LIM and SH3 domain protein 1metastatic lymph node gene 50 protein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q02641 | Q14847 | |
| Ensembl transtripts involved in fusion gene | ENST00000394303, ENST00000394310, ENST00000344140, ENST00000582877, | ENST00000318008, ENST00000433206, ENST00000435347, | |
| Fusion gene scores | * DoF score | 13 X 8 X 3=312 | 13 X 12 X 7=1092 |
| # samples | 12 | 16 | |
| ** MAII score | log2(12/312*10)=-1.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/1092*10)=-2.77082904603249 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CACNB1 [Title/Abstract] AND LASP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A0B7-01A | CACNB1 | chr17 | 37351137 | - | LASP1 | chr17 | 37054665 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394303 | ENST00000318008 | CACNB1 | chr17 | 37351137 | - | LASP1 | chr17 | 37054665 | + |
| In-frame | ENST00000394303 | ENST00000433206 | CACNB1 | chr17 | 37351137 | - | LASP1 | chr17 | 37054665 | + |
| In-frame | ENST00000394303 | ENST00000435347 | CACNB1 | chr17 | 37351137 | - | LASP1 | chr17 | 37054665 | + |
| In-frame | ENST00000394310 | ENST00000318008 | CACNB1 | chr17 | 37351137 | - | LASP1 | chr17 | 37054665 | + |
| In-frame | ENST00000394310 | ENST00000433206 | CACNB1 | chr17 | 37351137 | - | LASP1 | chr17 | 37054665 | + |
| In-frame | ENST00000394310 | ENST00000435347 | CACNB1 | chr17 | 37351137 | - | LASP1 | chr17 | 37054665 | + |
| In-frame | ENST00000344140 | ENST00000318008 | CACNB1 | chr17 | 37351137 | - | LASP1 | chr17 | 37054665 | + |
| In-frame | ENST00000344140 | ENST00000433206 | CACNB1 | chr17 | 37351137 | - | LASP1 | chr17 | 37054665 | + |
| In-frame | ENST00000344140 | ENST00000435347 | CACNB1 | chr17 | 37351137 | - | LASP1 | chr17 | 37054665 | + |
| 5UTR-3CDS | ENST00000582877 | ENST00000318008 | CACNB1 | chr17 | 37351137 | - | LASP1 | chr17 | 37054665 | + |
| 5UTR-3CDS | ENST00000582877 | ENST00000433206 | CACNB1 | chr17 | 37351137 | - | LASP1 | chr17 | 37054665 | + |
| 5UTR-3CDS | ENST00000582877 | ENST00000435347 | CACNB1 | chr17 | 37351137 | - | LASP1 | chr17 | 37054665 | + |
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FusionProtFeatures for CACNB1_LASP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CACNB1 | LASP1 |