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Fusion gene ID: 5224 |
FusionGeneSummary for CACNB1_CDC6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CACNB1_CDC6 | Fusion gene ID: 5224 | Hgene | Tgene | Gene symbol | CACNB1 | CDC6 | Gene ID | 782 | 990 |
| Gene name | calcium voltage-gated channel auxiliary subunit beta 1 | cell division cycle 6 | |
| Synonyms | CAB1|CACNLB1|CCHLB1 | CDC18L|HsCDC18|HsCDC6|MGORS5 | |
| Cytomap | 17q12 | 17q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | voltage-dependent L-type calcium channel subunit beta-1calcium channel voltage-dependent subunit beta 1calcium channel, L type, beta 1 polypeptidecalcium channel, voltage-dependent, beta 1 subunitdihydropyridine-sensitive L-type, calcium channel beta- | cell division control protein 6 homologCDC6 cell division cycle 6 homologCDC6-related proteincdc18-related proteincell division cycle 6 homologp62(cdc6) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q02641 | Q99741 | |
| Ensembl transtripts involved in fusion gene | ENST00000394303, ENST00000394310, ENST00000344140, ENST00000582877, | ENST00000209728, | |
| Fusion gene scores | * DoF score | 13 X 8 X 3=312 | 8 X 4 X 7=224 |
| # samples | 12 | 9 | |
| ** MAII score | log2(12/312*10)=-1.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/224*10)=-1.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CACNB1 [Title/Abstract] AND CDC6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CDC6 | GO:0051984 | positive regulation of chromosome segregation | 21041660 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AR-A0TX-01A | CACNB1 | chr17 | 37351137 | - | CDC6 | chr17 | 38445660 | + |
| TCGA | LD | BRCA | TCGA-BH-A0B7-01A | CACNB1 | chr17 | 37351137 | - | CDC6 | chr17 | 38457080 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000394303 | ENST00000209728 | CACNB1 | chr17 | 37351137 | - | CDC6 | chr17 | 38445660 | + |
| 5CDS-5UTR | ENST00000394310 | ENST00000209728 | CACNB1 | chr17 | 37351137 | - | CDC6 | chr17 | 38445660 | + |
| 5CDS-5UTR | ENST00000344140 | ENST00000209728 | CACNB1 | chr17 | 37351137 | - | CDC6 | chr17 | 38445660 | + |
| 5UTR-5UTR | ENST00000582877 | ENST00000209728 | CACNB1 | chr17 | 37351137 | - | CDC6 | chr17 | 38445660 | + |
| Frame-shift | ENST00000394303 | ENST00000209728 | CACNB1 | chr17 | 37351137 | - | CDC6 | chr17 | 38457080 | + |
| Frame-shift | ENST00000394310 | ENST00000209728 | CACNB1 | chr17 | 37351137 | - | CDC6 | chr17 | 38457080 | + |
| Frame-shift | ENST00000344140 | ENST00000209728 | CACNB1 | chr17 | 37351137 | - | CDC6 | chr17 | 38457080 | + |
| 5UTR-3CDS | ENST00000582877 | ENST00000209728 | CACNB1 | chr17 | 37351137 | - | CDC6 | chr17 | 38457080 | + |
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FusionProtFeatures for CACNB1_CDC6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CACNB1 | CDC6 |