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Fusion gene ID: 5222 |
FusionGeneSummary for CACNB1_ARRB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CACNB1_ARRB1 | Fusion gene ID: 5222 | Hgene | Tgene | Gene symbol | CACNB1 | ARRB1 | Gene ID | 782 | 408 |
| Gene name | calcium voltage-gated channel auxiliary subunit beta 1 | arrestin beta 1 | |
| Synonyms | CAB1|CACNLB1|CCHLB1 | ARB1|ARR1 | |
| Cytomap | 17q12 | 11q13.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | voltage-dependent L-type calcium channel subunit beta-1calcium channel voltage-dependent subunit beta 1calcium channel, L type, beta 1 polypeptidecalcium channel, voltage-dependent, beta 1 subunitdihydropyridine-sensitive L-type, calcium channel beta- | beta-arrestin-1arrestin 2non-visual arrestin-2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q02641 | P49407 | |
| Ensembl transtripts involved in fusion gene | ENST00000394303, ENST00000394310, ENST00000344140, ENST00000582877, | ENST00000420843, ENST00000393505, ENST00000360025, | |
| Fusion gene scores | * DoF score | 13 X 8 X 3=312 | 4 X 3 X 4=48 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/312*10)=-1.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CACNB1 [Title/Abstract] AND ARRB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ARRB1 | GO:0031397 | negative regulation of protein ubiquitination | 16378096 |
| Tgene | ARRB1 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 16378096 |
| Tgene | ARRB1 | GO:0032715 | negative regulation of interleukin-6 production | 16378096 |
| Tgene | ARRB1 | GO:0032717 | negative regulation of interleukin-8 production | 16378096 |
| Tgene | ARRB1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10644702 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A0HY-01A | CACNB1 | chr17 | 37343046 | - | ARRB1 | chr11 | 74985255 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394303 | ENST00000420843 | CACNB1 | chr17 | 37343046 | - | ARRB1 | chr11 | 74985255 | - |
| In-frame | ENST00000394303 | ENST00000393505 | CACNB1 | chr17 | 37343046 | - | ARRB1 | chr11 | 74985255 | - |
| In-frame | ENST00000394303 | ENST00000360025 | CACNB1 | chr17 | 37343046 | - | ARRB1 | chr11 | 74985255 | - |
| In-frame | ENST00000394310 | ENST00000420843 | CACNB1 | chr17 | 37343046 | - | ARRB1 | chr11 | 74985255 | - |
| In-frame | ENST00000394310 | ENST00000393505 | CACNB1 | chr17 | 37343046 | - | ARRB1 | chr11 | 74985255 | - |
| In-frame | ENST00000394310 | ENST00000360025 | CACNB1 | chr17 | 37343046 | - | ARRB1 | chr11 | 74985255 | - |
| In-frame | ENST00000344140 | ENST00000420843 | CACNB1 | chr17 | 37343046 | - | ARRB1 | chr11 | 74985255 | - |
| In-frame | ENST00000344140 | ENST00000393505 | CACNB1 | chr17 | 37343046 | - | ARRB1 | chr11 | 74985255 | - |
| In-frame | ENST00000344140 | ENST00000360025 | CACNB1 | chr17 | 37343046 | - | ARRB1 | chr11 | 74985255 | - |
| 5UTR-3CDS | ENST00000582877 | ENST00000420843 | CACNB1 | chr17 | 37343046 | - | ARRB1 | chr11 | 74985255 | - |
| 5UTR-3CDS | ENST00000582877 | ENST00000393505 | CACNB1 | chr17 | 37343046 | - | ARRB1 | chr11 | 74985255 | - |
| 5UTR-3CDS | ENST00000582877 | ENST00000360025 | CACNB1 | chr17 | 37343046 | - | ARRB1 | chr11 | 74985255 | - |
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FusionProtFeatures for CACNB1_ARRB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CACNB1 | ARRB1 |
| The beta subunit of voltage-dependent calcium channelscontributes to the function of the calcium channel by increasingpeak calcium current, shifting the voltage dependencies ofactivation and inactivation, modulating G protein inhibition andcontrolling the alpha-1 subunit membrane targeting. | Functions in regulating agonist-mediated G-proteincoupled receptor (GPCR) signaling by mediating both receptordesensitization and resensitization processes. During homologousdesensitization, beta-arrestins bind to the GPRK-phosphorylatedreceptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptordeterminants exposed only in the active receptor conformation. Thebeta-arrestins target many receptors for internalization by actingas endocytic adapters (CLASPs, clathrin-associated sortingproteins) and recruiting the GPRCs to the adapter protein 2complex 2 (AP-2) in clathrin-coated pits (CCPs). However, theextent of beta-arrestin involvement appears to vary significantlydepending on the receptor, agonist and cell type. Internalizedarrestin-receptor complexes traffic to intracellular endosomes,where they remain uncoupled from G-proteins. Two different modesof arrestin-mediated internalization occur. Class A receptors,like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapidrecycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR andTACR1 internalize as a complex with arrestin and traffic with itto endosomal vesicles, presumably as desensitized receptors, forextended periods of time. Receptor resensitization then requiresthat receptor-bound arrestin is removed so that the receptor canbe dephosphorylated and returned to the plasma membrane. Involvedin internalization of P2RY4 and UTP-stimulated internalization ofP2RY2. Involved in phosphorylation-dependent internalization ofOPRD1 ands subsequent recycling. Involved in the degradation ofcAMP by recruiting cAMP phosphodiesterases to ligand-activatedreceptors. Beta-arrestins function as multivalent adapter proteinsthat can switch the GPCR from a G-protein signaling mode thattransmits short-lived signals from the plasma membrane via smallmolecule second messengers and ion channels to a beta-arrestinsignaling mode that transmits a distinct set of signals that areinitiated as the receptor internalizes and transits theintracellular compartment. Acts as signaling scaffold for MAPKpathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus andconfined to cytoplasmic locations such as endocytic vesicles, alsocalled beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependentregulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs thebeta-arrestin-mediated signaling relies on either ARRB1 or ARRB2and is inhibited by the other respective beta-arrestin form(reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- andAVPR2-mediated activation (reciprocal regulation). Is required forSP-stimulated endocytosis of NK1R and recruits c-Src/SRC tointernalized NK1R resulting in ERK1/2 activation, which isrequired for the antiapoptotic effects of SP. Is involved inproteinase-activated F2RL1-mediated ERK activity. Acts assignaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulatedAKT1 signaling leading to increased protection from apoptosis.Involved in activation of the p38 MAPK signaling pathway and inactin bundle formation. Involved in F2RL1-mediated cytoskeletalrearrangement and chemotaxis. Involved in AGTR1-mediated stressfiber formation by acting together with GNAQ to activate RHOA.Appears to function as signaling scaffold involved in regulationof MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved inattenuation of NF-kappa-B-dependent transcription in response toGPCR or cytokine stimulation by interacting with and stabilizingCHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1Band FOS promoter regions and recruiting EP300 resulting inacetylation of histone H4. Involved in regulation of LEF1transcriptional activity via interaction with DVL1 and/or DVL2Also involved in regulation of receptors other than GPCRs.Involved in Toll-like receptor and IL-1 receptor signaling throughthe interaction with TRAF6 which prevents TRAF6 autoubiquitinationand oligomerization required for activation of NF-kappa-B and JUN.Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6)(By similarity). Involved in IL8-mediated granule release inneutrophils. Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin(CFL1) and for the up-regulation of ACKR2 from endosomalcompartment to cell membrane, increasing its efficiency inchemokine uptake and degradation. Involved in the internalizationof the atypical chemokine receptor ACKR3. Negatively regulates theNOTCH signaling pathway by mediating the ubiquitination anddegradation of NOTCH1 by ITCH. Participates to the recruitment ofthe ubiquitin-protein ligase to the receptor (PubMed:23886940).{ECO:0000250, ECO:0000269|PubMed:12464600,ECO:0000269|PubMed:14711824, ECO:0000269|PubMed:15475570,ECO:0000269|PubMed:15611106, ECO:0000269|PubMed:15671180,ECO:0000269|PubMed:15878855, ECO:0000269|PubMed:16144840,ECO:0000269|PubMed:16280323, ECO:0000269|PubMed:16378096,ECO:0000269|PubMed:16492667, ECO:0000269|PubMed:16709866,ECO:0000269|PubMed:18337459, ECO:0000269|PubMed:18419762,ECO:0000269|PubMed:19620252, ECO:0000269|PubMed:19643177,ECO:0000269|PubMed:22457824, ECO:0000269|PubMed:23341447,ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:23886940}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CACNB1 | chr17:37343046 | chr11:74985255 | ENST00000344140 | - | 5 | 13 | 100_169 | 183 | 524 | Domain | SH3 |
| Hgene | CACNB1 | chr17:37343046 | chr11:74985255 | ENST00000394303 | - | 5 | 14 | 100_169 | 183 | 599 | Domain | SH3 |
| Hgene | CACNB1 | chr17:37343046 | chr11:74985255 | ENST00000394310 | - | 5 | 13 | 100_169 | 183 | 479 | Domain | SH3 |
| Tgene | >ARRB1 | chr17:37343046 | chr11:74985255 | ENST00000360025 | - | 9 | 15 | 385_395 | 258 | 411 | Motif | Note=[DE]-X(1%2C2)-F-X-X-[FL]-X-X-X-R motif |
| Tgene | >ARRB1 | chr17:37343046 | chr11:74985255 | ENST00000420843 | - | 9 | 16 | 385_395 | 258 | 419 | Motif | Note=[DE]-X(1%2C2)-F-X-X-[FL]-X-X-X-R motif |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CACNB1_ARRB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CACNB1_ENST00000394303_chr17_37343046_-_ARRB1_ENST00000420843_chr11_74985255_-_344aa MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQAL AQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR LGSSDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAV >In-frame_CACNB1_ENST00000394303_chr17_37343046_-_ARRB1_ENST00000393505_chr11_74985255_-_344aa MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQAL AQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR LGSSDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLRGLCFSDVAV >In-frame_CACNB1_ENST00000394303_chr17_37343046_-_ARRB1_ENST00000360025_chr11_74985255_-_336aa MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQAL AQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR LGSSDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGDVAVELPFTLMH >In-frame_CACNB1_ENST00000394310_chr17_37343046_-_ARRB1_ENST00000420843_chr11_74985255_-_344aa MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQAL AQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR LGSSDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAV >In-frame_CACNB1_ENST00000394310_chr17_37343046_-_ARRB1_ENST00000393505_chr11_74985255_-_344aa MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQAL AQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR LGSSDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLRGLCFSDVAV >In-frame_CACNB1_ENST00000394310_chr17_37343046_-_ARRB1_ENST00000360025_chr11_74985255_-_336aa MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQAL AQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR LGSSDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGDVAVELPFTLMH >In-frame_CACNB1_ENST00000344140_chr17_37343046_-_ARRB1_ENST00000420843_chr11_74985255_-_344aa MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQAL AQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR LGSSDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAV >In-frame_CACNB1_ENST00000344140_chr17_37343046_-_ARRB1_ENST00000393505_chr11_74985255_-_344aa MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQAL AQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR LGSSDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLRGLCFSDVAV >In-frame_CACNB1_ENST00000344140_chr17_37343046_-_ARRB1_ENST00000360025_chr11_74985255_-_336aa MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQAL AQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR LGSSDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGDVAVELPFTLMH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CACNB1_ENST00000394303_chr17_37343046_-_ARRB1_ENST00000420843_chr11_74985255_-_1032nt ATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGAGGTCTTCGACCCCAGCCCGCAGGGCAAA TACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATCCAACAGCTTTGTCCGCCAGGGCTCAGCG GAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTTAAGGAAGGAAGCAGAGCGCCAGGCATTA GCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTACAATCCGTCTCCAGGGGATGAGGTGCCT GTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAATAATGACTGGTGGATCGGGCGGCTGGTG AAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCTGCAGGAACAGAAGCTGCGCCAGAACCGC CTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCCCTTCCTAGCCAATAACCGAGAGAAGCGG GGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTTGAGGGAAGGTGCCAACCGTGAGATCCTG GGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCCTGTTGGGAGATCTTGCATCCAGCGACGTGGCCGTG GAACTGCCCTTCACCCTAATGCACCCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCAGAGAACGAGACGCCAGTAGATACCAAT CTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACTGAAAGGCATGAAGGATGACAAGGAGGAA >In-frame_CACNB1_ENST00000394303_chr17_37343046_-_ARRB1_ENST00000393505_chr11_74985255_-_1032nt ATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGAGGTCTTCGACCCCAGCCCGCAGGGCAAA TACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATCCAACAGCTTTGTCCGCCAGGGCTCAGCG GAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTTAAGGAAGGAAGCAGAGCGCCAGGCATTA GCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTACAATCCGTCTCCAGGGGATGAGGTGCCT GTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAATAATGACTGGTGGATCGGGCGGCTGGTG AAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCTGCAGGAACAGAAGCTGCGCCAGAACCGC CTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCCCTTCCTAGCCAATAACCGAGAGAAGCGG GGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTTGAGGGAAGGTGCCAACCGTGAGATCCTG GGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCCTTCTCAGGGGTCTCTGTTTCAGCGACGTGGCCGTG GAACTGCCCTTCACCCTAATGCACCCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCAGAGAACGAGACGCCAGTAGATACCAAT CTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACTGAAAGGCATGAAGGATGACAAGGAGGAA >In-frame_CACNB1_ENST00000394303_chr17_37343046_-_ARRB1_ENST00000360025_chr11_74985255_-_1008nt ATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGAGGTCTTCGACCCCAGCCCGCAGGGCAAA TACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATCCAACAGCTTTGTCCGCCAGGGCTCAGCG GAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTTAAGGAAGGAAGCAGAGCGCCAGGCATTA GCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTACAATCCGTCTCCAGGGGATGAGGTGCCT GTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAATAATGACTGGTGGATCGGGCGGCTGGTG AAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCTGCAGGAACAGAAGCTGCGCCAGAACCGC CTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCCCTTCCTAGCCAATAACCGAGAGAAGCGG GGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTTGAGGGAAGGTGCCAACCGTGAGATCCTG GGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCGACGTGGCCGTGGAACTGCCCTTCACCCTAATGCAC CCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCAGAGAACGAGACGCCAGTAGATACCAATCTCATAGAACTTGACACAAATGAT GACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACTGAAAGGCATGAAGGATGACAAGGAGGAAGAGGAGGATGGTACCGGCTCTCCA >In-frame_CACNB1_ENST00000394310_chr17_37343046_-_ARRB1_ENST00000420843_chr11_74985255_-_1032nt ATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGAGGTCTTCGACCCCAGCCCGCAGGGCAAA TACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATCCAACAGCTTTGTCCGCCAGGGCTCAGCG GAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTTAAGGAAGGAAGCAGAGCGCCAGGCATTA GCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTACAATCCGTCTCCAGGGGATGAGGTGCCT GTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAATAATGACTGGTGGATCGGGCGGCTGGTG AAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCTGCAGGAACAGAAGCTGCGCCAGAACCGC CTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCCCTTCCTAGCCAATAACCGAGAGAAGCGG GGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTTGAGGGAAGGTGCCAACCGTGAGATCCTG GGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCCTGTTGGGAGATCTTGCATCCAGCGACGTGGCCGTG GAACTGCCCTTCACCCTAATGCACCCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCAGAGAACGAGACGCCAGTAGATACCAAT CTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACTGAAAGGCATGAAGGATGACAAGGAGGAA >In-frame_CACNB1_ENST00000394310_chr17_37343046_-_ARRB1_ENST00000393505_chr11_74985255_-_1032nt ATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGAGGTCTTCGACCCCAGCCCGCAGGGCAAA TACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATCCAACAGCTTTGTCCGCCAGGGCTCAGCG GAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTTAAGGAAGGAAGCAGAGCGCCAGGCATTA GCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTACAATCCGTCTCCAGGGGATGAGGTGCCT GTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAATAATGACTGGTGGATCGGGCGGCTGGTG AAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCTGCAGGAACAGAAGCTGCGCCAGAACCGC CTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCCCTTCCTAGCCAATAACCGAGAGAAGCGG GGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTTGAGGGAAGGTGCCAACCGTGAGATCCTG GGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCCTTCTCAGGGGTCTCTGTTTCAGCGACGTGGCCGTG GAACTGCCCTTCACCCTAATGCACCCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCAGAGAACGAGACGCCAGTAGATACCAAT CTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACTGAAAGGCATGAAGGATGACAAGGAGGAA >In-frame_CACNB1_ENST00000394310_chr17_37343046_-_ARRB1_ENST00000360025_chr11_74985255_-_1008nt ATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGAGGTCTTCGACCCCAGCCCGCAGGGCAAA TACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATCCAACAGCTTTGTCCGCCAGGGCTCAGCG GAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTTAAGGAAGGAAGCAGAGCGCCAGGCATTA GCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTACAATCCGTCTCCAGGGGATGAGGTGCCT GTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAATAATGACTGGTGGATCGGGCGGCTGGTG AAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCTGCAGGAACAGAAGCTGCGCCAGAACCGC CTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCCCTTCCTAGCCAATAACCGAGAGAAGCGG GGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTTGAGGGAAGGTGCCAACCGTGAGATCCTG GGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCGACGTGGCCGTGGAACTGCCCTTCACCCTAATGCAC CCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCAGAGAACGAGACGCCAGTAGATACCAATCTCATAGAACTTGACACAAATGAT GACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACTGAAAGGCATGAAGGATGACAAGGAGGAAGAGGAGGATGGTACCGGCTCTCCA >In-frame_CACNB1_ENST00000344140_chr17_37343046_-_ARRB1_ENST00000420843_chr11_74985255_-_1032nt ATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGAGGTCTTCGACCCCAGCCCGCAGGGCAAA TACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATCCAACAGCTTTGTCCGCCAGGGCTCAGCG GAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTTAAGGAAGGAAGCAGAGCGCCAGGCATTA GCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTACAATCCGTCTCCAGGGGATGAGGTGCCT GTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAATAATGACTGGTGGATCGGGCGGCTGGTG AAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCTGCAGGAACAGAAGCTGCGCCAGAACCGC CTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCCCTTCCTAGCCAATAACCGAGAGAAGCGG GGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTTGAGGGAAGGTGCCAACCGTGAGATCCTG GGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCCTGTTGGGAGATCTTGCATCCAGCGACGTGGCCGTG GAACTGCCCTTCACCCTAATGCACCCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCAGAGAACGAGACGCCAGTAGATACCAAT CTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACTGAAAGGCATGAAGGATGACAAGGAGGAA >In-frame_CACNB1_ENST00000344140_chr17_37343046_-_ARRB1_ENST00000393505_chr11_74985255_-_1032nt ATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGAGGTCTTCGACCCCAGCCCGCAGGGCAAA TACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATCCAACAGCTTTGTCCGCCAGGGCTCAGCG GAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTTAAGGAAGGAAGCAGAGCGCCAGGCATTA GCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTACAATCCGTCTCCAGGGGATGAGGTGCCT GTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAATAATGACTGGTGGATCGGGCGGCTGGTG AAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCTGCAGGAACAGAAGCTGCGCCAGAACCGC CTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCCCTTCCTAGCCAATAACCGAGAGAAGCGG GGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTTGAGGGAAGGTGCCAACCGTGAGATCCTG GGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCCTTCTCAGGGGTCTCTGTTTCAGCGACGTGGCCGTG GAACTGCCCTTCACCCTAATGCACCCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCAGAGAACGAGACGCCAGTAGATACCAAT CTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACTGAAAGGCATGAAGGATGACAAGGAGGAA >In-frame_CACNB1_ENST00000344140_chr17_37343046_-_ARRB1_ENST00000360025_chr11_74985255_-_1008nt ATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGAGGTCTTCGACCCCAGCCCGCAGGGCAAA TACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATCCAACAGCTTTGTCCGCCAGGGCTCAGCG GAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTTAAGGAAGGAAGCAGAGCGCCAGGCATTA GCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTACAATCCGTCTCCAGGGGATGAGGTGCCT GTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAATAATGACTGGTGGATCGGGCGGCTGGTG AAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCTGCAGGAACAGAAGCTGCGCCAGAACCGC CTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCCCTTCCTAGCCAATAACCGAGAGAAGCGG GGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTTGAGGGAAGGTGCCAACCGTGAGATCCTG GGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCGACGTGGCCGTGGAACTGCCCTTCACCCTAATGCAC CCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCAGAGAACGAGACGCCAGTAGATACCAATCTCATAGAACTTGACACAAATGAT GACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACTGAAAGGCATGAAGGATGACAAGGAGGAAGAGGAGGATGGTACCGGCTCTCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CACNB1_ENST00000394303_chr17_37343046_-_ARRB1_ENST00000420843_chr11_74985255_-_3221nt GAGATGCTGAGCCTACGGGGGAGGCGGCGGCGGCAGTGGAGAGAGCGGGAGGAGCGAGGGAAGGCAGGAAGGAGGCAGCCGAAGGCCGAG CTGGGTGGCTGGACCGGGTGCTGGCTGCGCCGCGCTGCTTTCGGCTCCCACGGCCTCTCCCATGCGCTGAGGGAGCCCGGCTGGGCCGGG CCGGCGGCGGGAGGGGAGGCTCCTCTCCATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGA GGTCTTCGACCCCAGCCCGCAGGGCAAATACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATC CAACAGCTTTGTCCGCCAGGGCTCAGCGGAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTT AAGGAAGGAAGCAGAGCGCCAGGCATTAGCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTA CAATCCGTCTCCAGGGGATGAGGTGCCTGTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAA TAATGACTGGTGGATCGGGCGGCTGGTGAAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCT GCAGGAACAGAAGCTGCGCCAGAACCGCCTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCC CTTCCTAGCCAATAACCGAGAGAAGCGGGGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTT GAGGGAAGGTGCCAACCGTGAGATCCTGGGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCCTGTTGGG AGATCTTGCATCCAGCGACGTGGCCGTGGAACTGCCCTTCACCCTAATGCACCCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCC AGAGAACGAGACGCCAGTAGATACCAATCTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACT GAAAGGCATGAAGGATGACAAGGAGGAAGAGGAGGATGGTACCGGCTCTCCACAGCTCAACAACAGATAGACGGGCCGGCCCTGCCTCCA CGTGGCTCCGGCTCCACTCTCGTGCACTCGGATGCTTACTCGTCTTCTTCCTGTTCTGGTTTCTTTTCCCCTTTGTTCTTCCAGTTTCTA CCAGGGGGCCCCGTGGGCTTCCAGATCACGGTGATGAACCTCTGGCCTCAGGATTGGCCCCACATCACCACGCCAACAGGACCACAGCGC ACTGGCTCCACCCCATCTCTGCCATCTCCACTCCCCTCCTTTTCATGCTGTCTCCCAGAAAAGCTGCCAGGGCTCTGGCCTTGGAATTGG ACTTGAGATGGGGAGCAGACAGGGGAGGATGGGGAATGTGGGACACGGTGTGGTGGGCATGAGGGCTTGGAGGGGTGGGGATGAGGGCTC AAGACACGAGAGAAGATGTCCACGGTCCCAGGTGGTTAACAAAGTTCTGGCAGCTAAAAGATGACCGCGTTGAAGGCCACCTCCTTCTGG CTGGGAGGGGCAGAACTGTGGACAGATTCTCAATGCCTTTTTGAAGTTCTGACCCACCAAAGACCTTCTGCCTTCACCCTCCTCCCCACC TGATGTCCCTCTGTGTCTGATAGTGATGTTGGTGAAAGTTCGTAGACCCCAGGAGTAGAGAAAAGCAACTGGACTGACTTTCTTACCAGC AGTTACCTAGACTGAGGCAAGCTGTGTGGACTCACCCAAGTATATTTCAGTACTGTCAGGCTGTGACATCTTAGCTACCTTGTATTTCAA GTGCATGGCCCTGTCTAGAGATATGCACAGAGAGAAAAGCAGAGGGAGGGAGGGAGGGGGTCTTCAGCAAGCACCAGCCCCCAGCAGAGT GAGCTGAAGCTCCTGAGGAGGGTTCCCGAAGGGGGGCGCTCAGAGATGGGGGCAGGGGGCGGGGAGAGGAGAGTCTGCCTTATGTCCCTT CCTTGTGGACTTCACATGGTCATGCAGGAAGTGAGGATGGGTGTCCAGCGGGGGCCGAGGCCACTAGTATCCTCCTGCTTCCCCCTGCCA TTCTCCAGGGCTGGACTGACCCTATGGACTGGGAGAGAGTGCCTGAGGCCACCATGCCACAGTCAAAGGGGGTCCTATCTCAGAAGGTGG CAGCATCCACTGAGATATCCTCACCCGAAGGGAAGGAGGCTGCTGGGTAGCAAATAAGCCCCTTCTTTTCTTGGTGAGTTGATGACCTCC AATAGCTCCCAGTGTCATGGGTACCCAGTACGCATTAGCTGGTGTTGGGTTGATTGAGACCTGGGGCAGTTCCTGGGGCAAGAAGCCAGA TGGGAGATGAGATAGAAAGTGTTAGGAGTTATCCTCTTTGCCTGGCCTTTGAGAATAACTTACTGTGTGACTTTGGGCAAGTTCCTTCCC CACTCTGGGCCTCAGTTTCTCACTTGGGAAAGCAAGGAGTTTGACCAGATGATCACAATGGGCCTTCCTAGCTCTGGCCACCAAGAATTT GTGAACATTAGAGCTCCTGGTCTGGTGGGTAGAGCCAGAGCTGCTGACTGGTCTCTCTGCCTCCAGAGGGGATTTATTGGACCTCAGAGG TGGCAGGGCCCTATGGAGCACCAACTGCCCTCAACCCCACCCTGTGCCCAAGACTGGGAAGGGATTGATGTCAGGCTGTGGCCATAGGTA GCATGAGTTGCCCAAGGAGGGACAGAGCATATCTTTGCTGAGGCTTGGCTGAGGGGCTTATGATAGGGCTTGCAGTACCTCACAGCCCCC TGTGGGCACAGACACCCTGAGGTTTACCCAGGCAAATATATTGATTAGCAGGACAAGGGCTCTCTCCTCAGTTTCTGCTCCCTTCCATCT CTCTCCCATACTTGTCTGAAAAGGGAGACAAAAAATCTTATACAAGTGGCATCTCAATCCTTTCCAGTCCAGCACCTCCTGGGGCAGGCA >In-frame_CACNB1_ENST00000394303_chr17_37343046_-_ARRB1_ENST00000393505_chr11_74985255_-_1965nt GAGATGCTGAGCCTACGGGGGAGGCGGCGGCGGCAGTGGAGAGAGCGGGAGGAGCGAGGGAAGGCAGGAAGGAGGCAGCCGAAGGCCGAG CTGGGTGGCTGGACCGGGTGCTGGCTGCGCCGCGCTGCTTTCGGCTCCCACGGCCTCTCCCATGCGCTGAGGGAGCCCGGCTGGGCCGGG CCGGCGGCGGGAGGGGAGGCTCCTCTCCATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGA GGTCTTCGACCCCAGCCCGCAGGGCAAATACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATC CAACAGCTTTGTCCGCCAGGGCTCAGCGGAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTT AAGGAAGGAAGCAGAGCGCCAGGCATTAGCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTA CAATCCGTCTCCAGGGGATGAGGTGCCTGTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAA TAATGACTGGTGGATCGGGCGGCTGGTGAAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCT GCAGGAACAGAAGCTGCGCCAGAACCGCCTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCC CTTCCTAGCCAATAACCGAGAGAAGCGGGGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTT GAGGGAAGGTGCCAACCGTGAGATCCTGGGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCCTTCTCAG GGGTCTCTGTTTCAGCGACGTGGCCGTGGAACTGCCCTTCACCCTAATGCACCCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCC AGAGAACGAGACGCCAGTAGATACCAATCTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACT GAAAGGCATGAAGGATGACAAGGAGGAAGAGGAGGATGGTACCGGCTCTCCACAGCTCAACAACAGATAGACGGGCCGGCCCTGCCTCCA CGTGGCTCCGGCTCCACTCTCGTGCACTCGGATGCTTACTCGTCTTCTTCCTGTTCTGGTTTCTTTTCCCCTTTGTTCTTCCAGTTTCTA CCAGGGGGCCCCGTGGGCTTCCAGATCACGGTGATGAACCTCTGGCCTCAGGATTGGCCCCACATCACCACGCCAACAGGACCACAGCGC ACTGGCTCCACCCCATCTCTGCCATCTCCACTCCCCTCCTTTTCATGCTGTCTCCCAGAAAAGCTGCCAGGGCTCTGGCCTTGGAATTGG ACTTGAGATGGGGAGCAGACAGGGGAGGATGGGGAATGTGGGACACGGTGTGGTGGGCATGAGGGCTTGGAGGGGTGGGGATGAGGGCTC AAGACACGAGAGAAGATGTCCACGGTCCCAGGTGGTTAACAAAGTTCTGGCAGCTAAAAGATGACCGCGTTGAAGGCCACCTCCTTCTGG CTGGGAGGGGCAGAACTGTGGACAGATTCTCAATGCCTTTTTGAAGTTCTGACCCACCAAAGACCTTCTGCCTTCACCCTCCTCCCCACC TGATGTCCCTCTGTGTCTGATAGTGATGTTGGTGAAAGTTCGTAGACCCCAGGAGTAGAGAAAAGCAACTGGACTGACTTTCTTACCAGC >In-frame_CACNB1_ENST00000394303_chr17_37343046_-_ARRB1_ENST00000360025_chr11_74985255_-_1780nt GAGATGCTGAGCCTACGGGGGAGGCGGCGGCGGCAGTGGAGAGAGCGGGAGGAGCGAGGGAAGGCAGGAAGGAGGCAGCCGAAGGCCGAG CTGGGTGGCTGGACCGGGTGCTGGCTGCGCCGCGCTGCTTTCGGCTCCCACGGCCTCTCCCATGCGCTGAGGGAGCCCGGCTGGGCCGGG CCGGCGGCGGGAGGGGAGGCTCCTCTCCATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGA GGTCTTCGACCCCAGCCCGCAGGGCAAATACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATC CAACAGCTTTGTCCGCCAGGGCTCAGCGGAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTT AAGGAAGGAAGCAGAGCGCCAGGCATTAGCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTA CAATCCGTCTCCAGGGGATGAGGTGCCTGTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAA TAATGACTGGTGGATCGGGCGGCTGGTGAAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCT GCAGGAACAGAAGCTGCGCCAGAACCGCCTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCC CTTCCTAGCCAATAACCGAGAGAAGCGGGGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTT GAGGGAAGGTGCCAACCGTGAGATCCTGGGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCGACGTGGC CGTGGAACTGCCCTTCACCCTAATGCACCCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCAGAGAACGAGACGCCAGTAGATAC CAATCTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACTGAAAGGCATGAAGGATGACAAGGA GGAAGAGGAGGATGGTACCGGCTCTCCACAGCTCAACAACAGATAGACGGGCCGGCCCTGCCTCCACGTGGCTCCGGCTCCACTCTCGTG CACTCGGATGCTTACTCGTCTTCTTCCTGTTCTGGTTTCTTTTCCCCTTTGTTCTTCCAGTTTCTACCAGGGGGCCCCGTGGGCTTCCAG ATCACGGTGATGAACCTCTGGCCTCAGGATTGGCCCCACATCACCACGCCAACAGGACCACAGCGCACTGGCTCCACCCCATCTCTGCCA TCTCCACTCCCCTCCTTTTCATGCTGTCTCCCAGAAAAGCTGCCAGGGCTCTGGCCTTGGAATTGGACTTGAGATGGGGAGCAGACAGGG GAGGATGGGGAATGTGGGACACGGTGTGGTGGGCATGAGGGCTTGGAGGGGTGGGGATGAGGGCTCAAGACACGAGAGAAGATGTCCACG GTCCCAGGTGGTTAACAAAGTTCTGGCAGCTAAAAGATGACCGCGTTGAAGGCCACCTCCTTCTGGCTGGGAGGGGCAGAACTGTGGACA >In-frame_CACNB1_ENST00000394310_chr17_37343046_-_ARRB1_ENST00000420843_chr11_74985255_-_3220nt AGATGCTGAGCCTACGGGGGAGGCGGCGGCGGCAGTGGAGAGAGCGGGAGGAGCGAGGGAAGGCAGGAAGGAGGCAGCCGAAGGCCGAGC TGGGTGGCTGGACCGGGTGCTGGCTGCGCCGCGCTGCTTTCGGCTCCCACGGCCTCTCCCATGCGCTGAGGGAGCCCGGCTGGGCCGGGC CGGCGGCGGGAGGGGAGGCTCCTCTCCATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGAG GTCTTCGACCCCAGCCCGCAGGGCAAATACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATCC AACAGCTTTGTCCGCCAGGGCTCAGCGGAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTTA AGGAAGGAAGCAGAGCGCCAGGCATTAGCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTAC AATCCGTCTCCAGGGGATGAGGTGCCTGTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAAT AATGACTGGTGGATCGGGCGGCTGGTGAAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCTG CAGGAACAGAAGCTGCGCCAGAACCGCCTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCCC TTCCTAGCCAATAACCGAGAGAAGCGGGGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTTG AGGGAAGGTGCCAACCGTGAGATCCTGGGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCCTGTTGGGA GATCTTGCATCCAGCGACGTGGCCGTGGAACTGCCCTTCACCCTAATGCACCCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCA GAGAACGAGACGCCAGTAGATACCAATCTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACTG AAAGGCATGAAGGATGACAAGGAGGAAGAGGAGGATGGTACCGGCTCTCCACAGCTCAACAACAGATAGACGGGCCGGCCCTGCCTCCAC GTGGCTCCGGCTCCACTCTCGTGCACTCGGATGCTTACTCGTCTTCTTCCTGTTCTGGTTTCTTTTCCCCTTTGTTCTTCCAGTTTCTAC CAGGGGGCCCCGTGGGCTTCCAGATCACGGTGATGAACCTCTGGCCTCAGGATTGGCCCCACATCACCACGCCAACAGGACCACAGCGCA CTGGCTCCACCCCATCTCTGCCATCTCCACTCCCCTCCTTTTCATGCTGTCTCCCAGAAAAGCTGCCAGGGCTCTGGCCTTGGAATTGGA CTTGAGATGGGGAGCAGACAGGGGAGGATGGGGAATGTGGGACACGGTGTGGTGGGCATGAGGGCTTGGAGGGGTGGGGATGAGGGCTCA AGACACGAGAGAAGATGTCCACGGTCCCAGGTGGTTAACAAAGTTCTGGCAGCTAAAAGATGACCGCGTTGAAGGCCACCTCCTTCTGGC TGGGAGGGGCAGAACTGTGGACAGATTCTCAATGCCTTTTTGAAGTTCTGACCCACCAAAGACCTTCTGCCTTCACCCTCCTCCCCACCT GATGTCCCTCTGTGTCTGATAGTGATGTTGGTGAAAGTTCGTAGACCCCAGGAGTAGAGAAAAGCAACTGGACTGACTTTCTTACCAGCA GTTACCTAGACTGAGGCAAGCTGTGTGGACTCACCCAAGTATATTTCAGTACTGTCAGGCTGTGACATCTTAGCTACCTTGTATTTCAAG TGCATGGCCCTGTCTAGAGATATGCACAGAGAGAAAAGCAGAGGGAGGGAGGGAGGGGGTCTTCAGCAAGCACCAGCCCCCAGCAGAGTG AGCTGAAGCTCCTGAGGAGGGTTCCCGAAGGGGGGCGCTCAGAGATGGGGGCAGGGGGCGGGGAGAGGAGAGTCTGCCTTATGTCCCTTC CTTGTGGACTTCACATGGTCATGCAGGAAGTGAGGATGGGTGTCCAGCGGGGGCCGAGGCCACTAGTATCCTCCTGCTTCCCCCTGCCAT TCTCCAGGGCTGGACTGACCCTATGGACTGGGAGAGAGTGCCTGAGGCCACCATGCCACAGTCAAAGGGGGTCCTATCTCAGAAGGTGGC AGCATCCACTGAGATATCCTCACCCGAAGGGAAGGAGGCTGCTGGGTAGCAAATAAGCCCCTTCTTTTCTTGGTGAGTTGATGACCTCCA ATAGCTCCCAGTGTCATGGGTACCCAGTACGCATTAGCTGGTGTTGGGTTGATTGAGACCTGGGGCAGTTCCTGGGGCAAGAAGCCAGAT GGGAGATGAGATAGAAAGTGTTAGGAGTTATCCTCTTTGCCTGGCCTTTGAGAATAACTTACTGTGTGACTTTGGGCAAGTTCCTTCCCC ACTCTGGGCCTCAGTTTCTCACTTGGGAAAGCAAGGAGTTTGACCAGATGATCACAATGGGCCTTCCTAGCTCTGGCCACCAAGAATTTG TGAACATTAGAGCTCCTGGTCTGGTGGGTAGAGCCAGAGCTGCTGACTGGTCTCTCTGCCTCCAGAGGGGATTTATTGGACCTCAGAGGT GGCAGGGCCCTATGGAGCACCAACTGCCCTCAACCCCACCCTGTGCCCAAGACTGGGAAGGGATTGATGTCAGGCTGTGGCCATAGGTAG CATGAGTTGCCCAAGGAGGGACAGAGCATATCTTTGCTGAGGCTTGGCTGAGGGGCTTATGATAGGGCTTGCAGTACCTCACAGCCCCCT GTGGGCACAGACACCCTGAGGTTTACCCAGGCAAATATATTGATTAGCAGGACAAGGGCTCTCTCCTCAGTTTCTGCTCCCTTCCATCTC TCTCCCATACTTGTCTGAAAAGGGAGACAAAAAATCTTATACAAGTGGCATCTCAATCCTTTCCAGTCCAGCACCTCCTGGGGCAGGCAG >In-frame_CACNB1_ENST00000394310_chr17_37343046_-_ARRB1_ENST00000393505_chr11_74985255_-_1964nt AGATGCTGAGCCTACGGGGGAGGCGGCGGCGGCAGTGGAGAGAGCGGGAGGAGCGAGGGAAGGCAGGAAGGAGGCAGCCGAAGGCCGAGC TGGGTGGCTGGACCGGGTGCTGGCTGCGCCGCGCTGCTTTCGGCTCCCACGGCCTCTCCCATGCGCTGAGGGAGCCCGGCTGGGCCGGGC CGGCGGCGGGAGGGGAGGCTCCTCTCCATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGAG GTCTTCGACCCCAGCCCGCAGGGCAAATACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATCC AACAGCTTTGTCCGCCAGGGCTCAGCGGAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTTA AGGAAGGAAGCAGAGCGCCAGGCATTAGCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTAC AATCCGTCTCCAGGGGATGAGGTGCCTGTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAAT AATGACTGGTGGATCGGGCGGCTGGTGAAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCTG CAGGAACAGAAGCTGCGCCAGAACCGCCTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCCC TTCCTAGCCAATAACCGAGAGAAGCGGGGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTTG AGGGAAGGTGCCAACCGTGAGATCCTGGGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCCTTCTCAGG GGTCTCTGTTTCAGCGACGTGGCCGTGGAACTGCCCTTCACCCTAATGCACCCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCA GAGAACGAGACGCCAGTAGATACCAATCTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACTG AAAGGCATGAAGGATGACAAGGAGGAAGAGGAGGATGGTACCGGCTCTCCACAGCTCAACAACAGATAGACGGGCCGGCCCTGCCTCCAC GTGGCTCCGGCTCCACTCTCGTGCACTCGGATGCTTACTCGTCTTCTTCCTGTTCTGGTTTCTTTTCCCCTTTGTTCTTCCAGTTTCTAC CAGGGGGCCCCGTGGGCTTCCAGATCACGGTGATGAACCTCTGGCCTCAGGATTGGCCCCACATCACCACGCCAACAGGACCACAGCGCA CTGGCTCCACCCCATCTCTGCCATCTCCACTCCCCTCCTTTTCATGCTGTCTCCCAGAAAAGCTGCCAGGGCTCTGGCCTTGGAATTGGA CTTGAGATGGGGAGCAGACAGGGGAGGATGGGGAATGTGGGACACGGTGTGGTGGGCATGAGGGCTTGGAGGGGTGGGGATGAGGGCTCA AGACACGAGAGAAGATGTCCACGGTCCCAGGTGGTTAACAAAGTTCTGGCAGCTAAAAGATGACCGCGTTGAAGGCCACCTCCTTCTGGC TGGGAGGGGCAGAACTGTGGACAGATTCTCAATGCCTTTTTGAAGTTCTGACCCACCAAAGACCTTCTGCCTTCACCCTCCTCCCCACCT GATGTCCCTCTGTGTCTGATAGTGATGTTGGTGAAAGTTCGTAGACCCCAGGAGTAGAGAAAAGCAACTGGACTGACTTTCTTACCAGCA >In-frame_CACNB1_ENST00000394310_chr17_37343046_-_ARRB1_ENST00000360025_chr11_74985255_-_1779nt AGATGCTGAGCCTACGGGGGAGGCGGCGGCGGCAGTGGAGAGAGCGGGAGGAGCGAGGGAAGGCAGGAAGGAGGCAGCCGAAGGCCGAGC TGGGTGGCTGGACCGGGTGCTGGCTGCGCCGCGCTGCTTTCGGCTCCCACGGCCTCTCCCATGCGCTGAGGGAGCCCGGCTGGGCCGGGC CGGCGGCGGGAGGGGAGGCTCCTCTCCATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGAG GTCTTCGACCCCAGCCCGCAGGGCAAATACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATCC AACAGCTTTGTCCGCCAGGGCTCAGCGGAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTTA AGGAAGGAAGCAGAGCGCCAGGCATTAGCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTAC AATCCGTCTCCAGGGGATGAGGTGCCTGTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAAT AATGACTGGTGGATCGGGCGGCTGGTGAAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCTG CAGGAACAGAAGCTGCGCCAGAACCGCCTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCCC TTCCTAGCCAATAACCGAGAGAAGCGGGGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTTG AGGGAAGGTGCCAACCGTGAGATCCTGGGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCGACGTGGCC GTGGAACTGCCCTTCACCCTAATGCACCCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCAGAGAACGAGACGCCAGTAGATACC AATCTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACTGAAAGGCATGAAGGATGACAAGGAG GAAGAGGAGGATGGTACCGGCTCTCCACAGCTCAACAACAGATAGACGGGCCGGCCCTGCCTCCACGTGGCTCCGGCTCCACTCTCGTGC ACTCGGATGCTTACTCGTCTTCTTCCTGTTCTGGTTTCTTTTCCCCTTTGTTCTTCCAGTTTCTACCAGGGGGCCCCGTGGGCTTCCAGA TCACGGTGATGAACCTCTGGCCTCAGGATTGGCCCCACATCACCACGCCAACAGGACCACAGCGCACTGGCTCCACCCCATCTCTGCCAT CTCCACTCCCCTCCTTTTCATGCTGTCTCCCAGAAAAGCTGCCAGGGCTCTGGCCTTGGAATTGGACTTGAGATGGGGAGCAGACAGGGG AGGATGGGGAATGTGGGACACGGTGTGGTGGGCATGAGGGCTTGGAGGGGTGGGGATGAGGGCTCAAGACACGAGAGAAGATGTCCACGG TCCCAGGTGGTTAACAAAGTTCTGGCAGCTAAAAGATGACCGCGTTGAAGGCCACCTCCTTCTGGCTGGGAGGGGCAGAACTGTGGACAG >In-frame_CACNB1_ENST00000344140_chr17_37343046_-_ARRB1_ENST00000420843_chr11_74985255_-_3221nt GAGATGCTGAGCCTACGGGGGAGGCGGCGGCGGCAGTGGAGAGAGCGGGAGGAGCGAGGGAAGGCAGGAAGGAGGCAGCCGAAGGCCGAG CTGGGTGGCTGGACCGGGTGCTGGCTGCGCCGCGCTGCTTTCGGCTCCCACGGCCTCTCCCATGCGCTGAGGGAGCCCGGCTGGGCCGGG CCGGCGGCGGGAGGGGAGGCTCCTCTCCATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGA GGTCTTCGACCCCAGCCCGCAGGGCAAATACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATC CAACAGCTTTGTCCGCCAGGGCTCAGCGGAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTT AAGGAAGGAAGCAGAGCGCCAGGCATTAGCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTA CAATCCGTCTCCAGGGGATGAGGTGCCTGTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAA TAATGACTGGTGGATCGGGCGGCTGGTGAAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCT GCAGGAACAGAAGCTGCGCCAGAACCGCCTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCC CTTCCTAGCCAATAACCGAGAGAAGCGGGGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTT GAGGGAAGGTGCCAACCGTGAGATCCTGGGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCCTGTTGGG AGATCTTGCATCCAGCGACGTGGCCGTGGAACTGCCCTTCACCCTAATGCACCCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCC AGAGAACGAGACGCCAGTAGATACCAATCTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACT GAAAGGCATGAAGGATGACAAGGAGGAAGAGGAGGATGGTACCGGCTCTCCACAGCTCAACAACAGATAGACGGGCCGGCCCTGCCTCCA CGTGGCTCCGGCTCCACTCTCGTGCACTCGGATGCTTACTCGTCTTCTTCCTGTTCTGGTTTCTTTTCCCCTTTGTTCTTCCAGTTTCTA CCAGGGGGCCCCGTGGGCTTCCAGATCACGGTGATGAACCTCTGGCCTCAGGATTGGCCCCACATCACCACGCCAACAGGACCACAGCGC ACTGGCTCCACCCCATCTCTGCCATCTCCACTCCCCTCCTTTTCATGCTGTCTCCCAGAAAAGCTGCCAGGGCTCTGGCCTTGGAATTGG ACTTGAGATGGGGAGCAGACAGGGGAGGATGGGGAATGTGGGACACGGTGTGGTGGGCATGAGGGCTTGGAGGGGTGGGGATGAGGGCTC AAGACACGAGAGAAGATGTCCACGGTCCCAGGTGGTTAACAAAGTTCTGGCAGCTAAAAGATGACCGCGTTGAAGGCCACCTCCTTCTGG CTGGGAGGGGCAGAACTGTGGACAGATTCTCAATGCCTTTTTGAAGTTCTGACCCACCAAAGACCTTCTGCCTTCACCCTCCTCCCCACC TGATGTCCCTCTGTGTCTGATAGTGATGTTGGTGAAAGTTCGTAGACCCCAGGAGTAGAGAAAAGCAACTGGACTGACTTTCTTACCAGC AGTTACCTAGACTGAGGCAAGCTGTGTGGACTCACCCAAGTATATTTCAGTACTGTCAGGCTGTGACATCTTAGCTACCTTGTATTTCAA GTGCATGGCCCTGTCTAGAGATATGCACAGAGAGAAAAGCAGAGGGAGGGAGGGAGGGGGTCTTCAGCAAGCACCAGCCCCCAGCAGAGT GAGCTGAAGCTCCTGAGGAGGGTTCCCGAAGGGGGGCGCTCAGAGATGGGGGCAGGGGGCGGGGAGAGGAGAGTCTGCCTTATGTCCCTT CCTTGTGGACTTCACATGGTCATGCAGGAAGTGAGGATGGGTGTCCAGCGGGGGCCGAGGCCACTAGTATCCTCCTGCTTCCCCCTGCCA TTCTCCAGGGCTGGACTGACCCTATGGACTGGGAGAGAGTGCCTGAGGCCACCATGCCACAGTCAAAGGGGGTCCTATCTCAGAAGGTGG CAGCATCCACTGAGATATCCTCACCCGAAGGGAAGGAGGCTGCTGGGTAGCAAATAAGCCCCTTCTTTTCTTGGTGAGTTGATGACCTCC AATAGCTCCCAGTGTCATGGGTACCCAGTACGCATTAGCTGGTGTTGGGTTGATTGAGACCTGGGGCAGTTCCTGGGGCAAGAAGCCAGA TGGGAGATGAGATAGAAAGTGTTAGGAGTTATCCTCTTTGCCTGGCCTTTGAGAATAACTTACTGTGTGACTTTGGGCAAGTTCCTTCCC CACTCTGGGCCTCAGTTTCTCACTTGGGAAAGCAAGGAGTTTGACCAGATGATCACAATGGGCCTTCCTAGCTCTGGCCACCAAGAATTT GTGAACATTAGAGCTCCTGGTCTGGTGGGTAGAGCCAGAGCTGCTGACTGGTCTCTCTGCCTCCAGAGGGGATTTATTGGACCTCAGAGG TGGCAGGGCCCTATGGAGCACCAACTGCCCTCAACCCCACCCTGTGCCCAAGACTGGGAAGGGATTGATGTCAGGCTGTGGCCATAGGTA GCATGAGTTGCCCAAGGAGGGACAGAGCATATCTTTGCTGAGGCTTGGCTGAGGGGCTTATGATAGGGCTTGCAGTACCTCACAGCCCCC TGTGGGCACAGACACCCTGAGGTTTACCCAGGCAAATATATTGATTAGCAGGACAAGGGCTCTCTCCTCAGTTTCTGCTCCCTTCCATCT CTCTCCCATACTTGTCTGAAAAGGGAGACAAAAAATCTTATACAAGTGGCATCTCAATCCTTTCCAGTCCAGCACCTCCTGGGGCAGGCA >In-frame_CACNB1_ENST00000344140_chr17_37343046_-_ARRB1_ENST00000393505_chr11_74985255_-_1965nt GAGATGCTGAGCCTACGGGGGAGGCGGCGGCGGCAGTGGAGAGAGCGGGAGGAGCGAGGGAAGGCAGGAAGGAGGCAGCCGAAGGCCGAG CTGGGTGGCTGGACCGGGTGCTGGCTGCGCCGCGCTGCTTTCGGCTCCCACGGCCTCTCCCATGCGCTGAGGGAGCCCGGCTGGGCCGGG CCGGCGGCGGGAGGGGAGGCTCCTCTCCATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGA GGTCTTCGACCCCAGCCCGCAGGGCAAATACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATC CAACAGCTTTGTCCGCCAGGGCTCAGCGGAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTT AAGGAAGGAAGCAGAGCGCCAGGCATTAGCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTA CAATCCGTCTCCAGGGGATGAGGTGCCTGTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAA TAATGACTGGTGGATCGGGCGGCTGGTGAAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCT GCAGGAACAGAAGCTGCGCCAGAACCGCCTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCC CTTCCTAGCCAATAACCGAGAGAAGCGGGGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTT GAGGGAAGGTGCCAACCGTGAGATCCTGGGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCCTTCTCAG GGGTCTCTGTTTCAGCGACGTGGCCGTGGAACTGCCCTTCACCCTAATGCACCCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCC AGAGAACGAGACGCCAGTAGATACCAATCTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACT GAAAGGCATGAAGGATGACAAGGAGGAAGAGGAGGATGGTACCGGCTCTCCACAGCTCAACAACAGATAGACGGGCCGGCCCTGCCTCCA CGTGGCTCCGGCTCCACTCTCGTGCACTCGGATGCTTACTCGTCTTCTTCCTGTTCTGGTTTCTTTTCCCCTTTGTTCTTCCAGTTTCTA CCAGGGGGCCCCGTGGGCTTCCAGATCACGGTGATGAACCTCTGGCCTCAGGATTGGCCCCACATCACCACGCCAACAGGACCACAGCGC ACTGGCTCCACCCCATCTCTGCCATCTCCACTCCCCTCCTTTTCATGCTGTCTCCCAGAAAAGCTGCCAGGGCTCTGGCCTTGGAATTGG ACTTGAGATGGGGAGCAGACAGGGGAGGATGGGGAATGTGGGACACGGTGTGGTGGGCATGAGGGCTTGGAGGGGTGGGGATGAGGGCTC AAGACACGAGAGAAGATGTCCACGGTCCCAGGTGGTTAACAAAGTTCTGGCAGCTAAAAGATGACCGCGTTGAAGGCCACCTCCTTCTGG CTGGGAGGGGCAGAACTGTGGACAGATTCTCAATGCCTTTTTGAAGTTCTGACCCACCAAAGACCTTCTGCCTTCACCCTCCTCCCCACC TGATGTCCCTCTGTGTCTGATAGTGATGTTGGTGAAAGTTCGTAGACCCCAGGAGTAGAGAAAAGCAACTGGACTGACTTTCTTACCAGC >In-frame_CACNB1_ENST00000344140_chr17_37343046_-_ARRB1_ENST00000360025_chr11_74985255_-_1780nt GAGATGCTGAGCCTACGGGGGAGGCGGCGGCGGCAGTGGAGAGAGCGGGAGGAGCGAGGGAAGGCAGGAAGGAGGCAGCCGAAGGCCGAG CTGGGTGGCTGGACCGGGTGCTGGCTGCGCCGCGCTGCTTTCGGCTCCCACGGCCTCTCCCATGCGCTGAGGGAGCCCGGCTGGGCCGGG CCGGCGGCGGGAGGGGAGGCTCCTCTCCATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGA GGTCTTCGACCCCAGCCCGCAGGGCAAATACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTCGGATACCACATC CAACAGCTTTGTCCGCCAGGGCTCAGCGGAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTT AAGGAAGGAAGCAGAGCGCCAGGCATTAGCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTA CAATCCGTCTCCAGGGGATGAGGTGCCTGTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACAA TAATGACTGGTGGATCGGGCGGCTGGTGAAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCAAACTGGACAGCCTTCGCCTGCT GCAGGAACAGAAGCTGCGCCAGAACCGCCTCGGCTCCAGTGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGACCCC CTTCCTAGCCAATAACCGAGAGAAGCGGGGCCTCGCCTTGGACGGGAAGCTCAAGCACGAAGACACGAACTTGGCCTCTAGCACCCTGTT GAGGGAAGGTGCCAACCGTGAGATCCTGGGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCGACGTGGC CGTGGAACTGCCCTTCACCCTAATGCACCCCAAGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCAGAGAACGAGACGCCAGTAGATAC CAATCTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGAGACTGAAAGGCATGAAGGATGACAAGGA GGAAGAGGAGGATGGTACCGGCTCTCCACAGCTCAACAACAGATAGACGGGCCGGCCCTGCCTCCACGTGGCTCCGGCTCCACTCTCGTG CACTCGGATGCTTACTCGTCTTCTTCCTGTTCTGGTTTCTTTTCCCCTTTGTTCTTCCAGTTTCTACCAGGGGGCCCCGTGGGCTTCCAG ATCACGGTGATGAACCTCTGGCCTCAGGATTGGCCCCACATCACCACGCCAACAGGACCACAGCGCACTGGCTCCACCCCATCTCTGCCA TCTCCACTCCCCTCCTTTTCATGCTGTCTCCCAGAAAAGCTGCCAGGGCTCTGGCCTTGGAATTGGACTTGAGATGGGGAGCAGACAGGG GAGGATGGGGAATGTGGGACACGGTGTGGTGGGCATGAGGGCTTGGAGGGGTGGGGATGAGGGCTCAAGACACGAGAGAAGATGTCCACG GTCCCAGGTGGTTAACAAAGTTCTGGCAGCTAAAAGATGACCGCGTTGAAGGCCACCTCCTTCTGGCTGGGAGGGGCAGAACTGTGGACA |
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FusionGenePPI for CACNB1_ARRB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CACNB1 | NEDD4L, ATN1, APP, SRPK1, CACNB2, CACNB3, C19orf26, KLHL15, WDR75 | ARRB1 | ZBTB43, GNMT, KHK, NOLC1, AP3B1, TCOF1, CHD1, BOP1, ARR3, ARRB2, PES1, DDX27, KPNA3, ZRANB2, RPL7L1, CCL14, JAK1, RTF1, HDGFRP2, CSNK2A1, CMBL, CCR5, MAPK10, DVL2, DVL1, RALGDS, ARF6, CYTH2, OPRD1, CXCR2, ADRB1, CSK, MDM2, NSF, PTHLH, NEDD4, ITCH, CDC42, JUN, SREBF2, USP33, PARK2, HGS, STAM, SLC9A1, MAP3K5, STUB1, PDE4D, MAPK3, MAPK1, GSK3B, IGF1R, SAG, YWHAB, YWHAG, YWHAQ, YWHAH, YWHAE, YWHAZ, RANBP9, STK38, SCYL2, DGKZ, DGKE, DGKG, ROCK1, YES1, ATR, PPM1A, PPM1B, CLTA, CLTC, AP3D1, RAB11FIP5, LRP4, LRP1B, DNM1, RGS3, RAB1A, ANXA2, PTCH2, SDC3, HIST1H1C, HIST1H2BO, HIST2H4A, HIST2H2AB, H3F3B, PRMT5, NPM1, POLR1A, POLR1C, POLR1E, CD3EAP, THRAP3, TMPO, YBX1, ALYREF, NOP10, RBM10, SF3B2, NCL, SNRPD1, SRRM2, HNRNPM, HNRNPK, DKC1, HNRNPA3, EIF4B, EEF1A2, RPL22, RPS3A, RPS17, IGF2BP2, ACTA1, TUBA4A, TUBA3C, TUBA1C, TUBB, VIM, TUBB2A, FLNA, GSN, LIMA1, MPRIP, CALD1, MAP1B, SPTAN1, TPM4, CKAP4, MYH9, MYL12B, KIF26A, MYH1, FASN, PKM, DHRS2, ATP5A1, ATP5B, PFKFB3, P4HB, HSPA8, HSP90AA1, CNGA3, HSPA5, APLP1, HSPA9, BCLAF1, RPS27A, UBB, UBC, UBA52, CPA1, CSN2, WDR77, DGKH, STK38L, MAP3K1, PIK3R2, PIK3C2A, STXBP5, CPNE8, ARHGAP32, G3BP1, S100A9, ZYX, HIST1H2AG, H2AFX, H1FX, XRCC5, POLR2E, BACH2, HNRNPU, HNRNPH1, HNRNPA1, RPL3, RPS2, RPS8, RPL6, RPL7A, EIF3I, TMOD3, CFL1, CTTN, ARPC5, KTN1, TTN, INA, DMD, MYO1C, MYL6, KIF2C, KIF3A, DNAH3, ACACA, HSPA1B, HSPA7, KCTD3, USP24, SPIN1, HDLBP, DPY30, CALM3, PRPF4, POT1, ADRBK1, TRAF6, HCRTR1, GNB1, GNG2, SNCA, SLC9A5, GPR50, C5AR1, ARRDC3, ARRDC4, NFKBIA, YY1, EDNRA, SRC, AXIN1, MAP2K4, AGTR1, AKT1, PDXP, LIMK1, PTAFR, AP2A1, MAP2K3, MAPK14, ARRDC1, NOTCH1, RPL15, BAG1, NEK6, BTK, ADH6, MAPK9, PTGER4, EGFR, CYTH1, DRD4, KLHL12, CUL3, KBTBD8, BRPF1, DOCK4, ALDH4A1, LYRM7, ACIN1, DCAF5, ELMO2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | ARRB1 | chr17:37343046 | chr11:74985255 | ENST00000360025 | - | 9 | 15 | 318_418 | 258 | 411 | TRAF6 |
| Tgene | ARRB1 | chr17:37343046 | chr11:74985255 | ENST00000420843 | - | 9 | 16 | 318_418 | 258 | 419 | TRAF6 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | ARRB1 | chr17:37343046 | chr11:74985255 | ENST00000360025 | - | 9 | 15 | 45_86 | 258 | 411 | CHRM2 |
| Tgene | ARRB1 | chr17:37343046 | chr11:74985255 | ENST00000420843 | - | 9 | 16 | 45_86 | 258 | 419 | CHRM2 |
| Tgene | ARRB1 | chr17:37343046 | chr11:74985255 | ENST00000360025 | - | 9 | 15 | 1_163 | 258 | 411 | SRC |
| Tgene | ARRB1 | chr17:37343046 | chr11:74985255 | ENST00000420843 | - | 9 | 16 | 1_163 | 258 | 419 | SRC |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CACNB1_ARRB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | CACNB1 | Q02641 | DB00308 | Ibutilide | Voltage-dependent L-type calcium channel subunit beta-1 | small molecule | approved |
| Hgene | CACNB1 | Q02641 | DB00661 | Verapamil | Voltage-dependent L-type calcium channel subunit beta-1 | small molecule | approved |
| Hgene | CACNB1 | Q02641 | DB00898 | Ethanol | Voltage-dependent L-type calcium channel subunit beta-1 | small molecule | approved |
| Hgene | CACNB1 | Q02641 | DB04855 | Dronedarone | Voltage-dependent L-type calcium channel subunit beta-1 | small molecule | approved |
| Hgene | CACNB1 | Q02641 | DB00393 | Nimodipine | Voltage-dependent L-type calcium channel subunit beta-1 | small molecule | approved|investigational |
| Hgene | CACNB1 | Q02641 | DB00653 | Magnesium sulfate | Voltage-dependent L-type calcium channel subunit beta-1 | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for CACNB1_ARRB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ARRB1 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Tgene | ARRB1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | ARRB1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | ARRB1 | C3178803 | Social Anhedonia | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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