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Fusion gene ID: 5215

FusionGeneSummary for CACNA2D3_DAP3

Fusion gene summary

Fusion gene information	Fusion gene name: CACNA2D3_DAP3
	Fusion gene ID: 5215
		Hgene	Tgene
	Gene symbol	CACNA2D3	DAP3
	Gene ID	55799	58512
	Gene name	calcium voltage-gated channel auxiliary subunit alpha2delta 3	DLG associated protein 3
	Synonyms	HSA272268	DAP3\|SAPAP3
	Cytomap	3p21.1-p14.3	1p34.3
	Type of gene	protein-coding	protein-coding
	Description	voltage-dependent calcium channel subunit alpha-2/delta-3calcium channel alpha2-delta3 subunitcalcium channel, voltage-dependent, alpha 2/delta 3 subunitcalcium channel, voltage-dependent, alpha 2/delta subunit 3voltage-gated calcium channel subunit a	disks large-associated protein 3DAP-3PSD-95/SAP90-binding protein 3SAP90/PSD-95-associated protein 3discs large homolog associated protein 3
	Modification date	20180522	20180519
	UniProtAcc	Q8IZS8	P51398
	Ensembl transtripts involved in fusion gene	ENST00000415676, ENST00000288197, ENST00000474759, ENST00000490478, ENST00000478261,	ENST00000471642, ENST00000368336, ENST00000343043, ENST00000496863, ENST00000535183, ENST00000421487, ENST00000465375,
Fusion gene scores	* DoF score	7 X 7 X 5=245	3 X 2 X 2=12
	# samples	7	3
	** MAII score	log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CACNA2D3 [Title/Abstract] AND DAP3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	OV	TCGA-20-1684-01A	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000415676	ENST00000471642	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
In-frame	ENST00000415676	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
Frame-shift	ENST00000415676	ENST00000343043	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000415676	ENST00000496863	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000415676	ENST00000535183	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000415676	ENST00000421487	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000415676	ENST00000465375	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
Frame-shift	ENST00000288197	ENST00000471642	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
In-frame	ENST00000288197	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
Frame-shift	ENST00000288197	ENST00000343043	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000288197	ENST00000496863	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000288197	ENST00000535183	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000288197	ENST00000421487	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000288197	ENST00000465375	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
Frame-shift	ENST00000474759	ENST00000471642	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
In-frame	ENST00000474759	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
Frame-shift	ENST00000474759	ENST00000343043	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000474759	ENST00000496863	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000474759	ENST00000535183	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000474759	ENST00000421487	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000474759	ENST00000465375	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
Frame-shift	ENST00000490478	ENST00000471642	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
In-frame	ENST00000490478	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
Frame-shift	ENST00000490478	ENST00000343043	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000490478	ENST00000496863	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000490478	ENST00000535183	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000490478	ENST00000421487	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
5CDS-intron	ENST00000490478	ENST00000465375	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
intron-3CDS	ENST00000478261	ENST00000471642	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
intron-3CDS	ENST00000478261	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
intron-3CDS	ENST00000478261	ENST00000343043	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
intron-intron	ENST00000478261	ENST00000496863	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
intron-intron	ENST00000478261	ENST00000535183	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
intron-intron	ENST00000478261	ENST00000421487	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
intron-intron	ENST00000478261	ENST00000465375	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+

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FusionProtFeatures for CACNA2D3_DAP3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CACNA2D3 Q8IZS8	DAP3 P51398

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Fusion gene ID: 5215

FusionGeneSummary for CACNA2D3_DAP3

FusionProtFeatures for CACNA2D3_DAP3