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Fusion gene ID: 5144 |
FusionGeneSummary for CAB39_CAB39 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CAB39_CAB39 | Fusion gene ID: 5144 | Hgene | Tgene | Gene symbol | CAB39 | CAB39 | Gene ID | 51719 | 51719 |
| Gene name | calcium binding protein 39 | calcium binding protein 39 | |
| Synonyms | CGI-66|MO25 | CGI-66|MO25 | |
| Cytomap | 2q37.1 | 2q37.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calcium-binding protein 39MO25alpha | calcium-binding protein 39MO25alpha | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y376 | Q9Y376 | |
| Ensembl transtripts involved in fusion gene | ENST00000258418, ENST00000410084, ENST00000409788, ENST00000484398, | ENST00000258418, ENST00000410084, ENST00000409788, ENST00000484398, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 5 X 5 X 3=75 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/75*10)=-0.0995356735509144 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CAB39 [Title/Abstract] AND CAB39 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CAB39 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 24393035 |
| Hgene | CAB39 | GO:0018105 | peptidyl-serine phosphorylation | 24393035 |
| Hgene | CAB39 | GO:0023014 | signal transduction by protein phosphorylation | 24393035 |
| Hgene | CAB39 | GO:0035556 | intracellular signal transduction | 24393035 |
| Hgene | CAB39 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 19892943|24393035 |
| Tgene | CAB39 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 24393035 |
| Tgene | CAB39 | GO:0018105 | peptidyl-serine phosphorylation | 24393035 |
| Tgene | CAB39 | GO:0023014 | signal transduction by protein phosphorylation | 24393035 |
| Tgene | CAB39 | GO:0035556 | intracellular signal transduction | 24393035 |
| Tgene | CAB39 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 19892943|24393035 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AF134480 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - | ||
| ChiTaRS3.1 | F00930 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - | ||
| ChiTaRS3.1 | AF151824 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000258418 | ENST00000258418 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| 3UTR-intron | ENST00000258418 | ENST00000410084 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| 3UTR-intron | ENST00000258418 | ENST00000409788 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| 3UTR-intron | ENST00000258418 | ENST00000484398 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| intron-3UTR | ENST00000410084 | ENST00000258418 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| intron-intron | ENST00000410084 | ENST00000410084 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| intron-intron | ENST00000410084 | ENST00000409788 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| intron-intron | ENST00000410084 | ENST00000484398 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| intron-3UTR | ENST00000409788 | ENST00000258418 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| intron-intron | ENST00000409788 | ENST00000410084 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| intron-intron | ENST00000409788 | ENST00000409788 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| intron-intron | ENST00000409788 | ENST00000484398 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| intron-3UTR | ENST00000484398 | ENST00000258418 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| intron-intron | ENST00000484398 | ENST00000410084 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| intron-intron | ENST00000484398 | ENST00000409788 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
| intron-intron | ENST00000484398 | ENST00000484398 | CAB39 | chr2 | 231683960 | + | CAB39 | chr2 | 231683565 | - |
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FusionProtFeatures for CAB39_CAB39 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CAB39 | CAB39 |