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Fusion gene ID: 5101 |
FusionGeneSummary for C8orf76_ATAD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C8orf76_ATAD2 | Fusion gene ID: 5101 | Hgene | Tgene | Gene symbol | C8orf76 | ATAD2 | Gene ID | 84933 | 29028 |
| Gene name | chromosome 8 open reading frame 76 | ATPase family, AAA domain containing 2 | |
| Synonyms | - | ANCCA|CT137|PRO2000 | |
| Cytomap | 8q24.13 | 8q24.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | uncharacterized protein C8orf76 | ATPase family AAA domain-containing protein 2AAA nuclear coregulator cancer-associated protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96K31 | Q6PL18 | |
| Ensembl transtripts involved in fusion gene | ENST00000276704, ENST00000521310, | ENST00000287394, ENST00000521903, ENST00000534257, | |
| Fusion gene scores | * DoF score | 2 X 3 X 4=24 | 6 X 6 X 7=252 |
| # samples | 4 | 8 | |
| ** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/252*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: C8orf76 [Title/Abstract] AND ATAD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ATAD2 | GO:0045893 | positive regulation of transcription, DNA-templated | 17998543 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-4Z-AA7Q-01A | C8orf76 | chr8 | 124238740 | - | ATAD2 | chr8 | 124335306 | - |
| TCGA | RV | KIRC | TCGA-BP-4962-01A | C8orf76 | chr8 | 124250038 | - | ATAD2 | chr8 | 124351686 | - |
| TCGA | RV | PRAD | TCGA-HC-7233-01A | C8orf76 | chr8 | 124253470 | - | ATAD2 | chr8 | 124361684 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000276704 | ENST00000287394 | C8orf76 | chr8 | 124238740 | - | ATAD2 | chr8 | 124335306 | - |
| In-frame | ENST00000276704 | ENST00000521903 | C8orf76 | chr8 | 124238740 | - | ATAD2 | chr8 | 124335306 | - |
| 5CDS-intron | ENST00000276704 | ENST00000534257 | C8orf76 | chr8 | 124238740 | - | ATAD2 | chr8 | 124335306 | - |
| In-frame | ENST00000521310 | ENST00000287394 | C8orf76 | chr8 | 124238740 | - | ATAD2 | chr8 | 124335306 | - |
| In-frame | ENST00000521310 | ENST00000521903 | C8orf76 | chr8 | 124238740 | - | ATAD2 | chr8 | 124335306 | - |
| 5CDS-intron | ENST00000521310 | ENST00000534257 | C8orf76 | chr8 | 124238740 | - | ATAD2 | chr8 | 124335306 | - |
| In-frame | ENST00000276704 | ENST00000287394 | C8orf76 | chr8 | 124250038 | - | ATAD2 | chr8 | 124351686 | - |
| In-frame | ENST00000276704 | ENST00000521903 | C8orf76 | chr8 | 124250038 | - | ATAD2 | chr8 | 124351686 | - |
| 5CDS-intron | ENST00000276704 | ENST00000534257 | C8orf76 | chr8 | 124250038 | - | ATAD2 | chr8 | 124351686 | - |
| 5UTR-3CDS | ENST00000521310 | ENST00000287394 | C8orf76 | chr8 | 124250038 | - | ATAD2 | chr8 | 124351686 | - |
| 5UTR-3CDS | ENST00000521310 | ENST00000521903 | C8orf76 | chr8 | 124250038 | - | ATAD2 | chr8 | 124351686 | - |
| 5UTR-intron | ENST00000521310 | ENST00000534257 | C8orf76 | chr8 | 124250038 | - | ATAD2 | chr8 | 124351686 | - |
| Frame-shift | ENST00000276704 | ENST00000287394 | C8orf76 | chr8 | 124253470 | - | ATAD2 | chr8 | 124361684 | - |
| 5CDS-intron | ENST00000276704 | ENST00000521903 | C8orf76 | chr8 | 124253470 | - | ATAD2 | chr8 | 124361684 | - |
| 5CDS-intron | ENST00000276704 | ENST00000534257 | C8orf76 | chr8 | 124253470 | - | ATAD2 | chr8 | 124361684 | - |
| 5UTR-3CDS | ENST00000521310 | ENST00000287394 | C8orf76 | chr8 | 124253470 | - | ATAD2 | chr8 | 124361684 | - |
| 5UTR-intron | ENST00000521310 | ENST00000521903 | C8orf76 | chr8 | 124253470 | - | ATAD2 | chr8 | 124361684 | - |
| 5UTR-intron | ENST00000521310 | ENST00000534257 | C8orf76 | chr8 | 124253470 | - | ATAD2 | chr8 | 124361684 | - |
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FusionProtFeatures for C8orf76_ATAD2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C8orf76 | ATAD2 |