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Fusion gene ID: 5086 |
FusionGeneSummary for C7orf50_CD177 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C7orf50_CD177 | Fusion gene ID: 5086 | Hgene | Tgene | Gene symbol | C7orf50 | CD177 | Gene ID | 84310 | 57126 |
| Gene name | chromosome 7 open reading frame 50 | CD177 molecule | |
| Synonyms | YCR016W | HNA-2a|HNA2A|NB1|NB1 GP|PRV-1|PRV1 | |
| Cytomap | 7p22.3 | 19q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | uncharacterized protein C7orf50 | CD177 antigenNB1 glycoproteincell surface receptorhuman neutrophil alloantigen 2apolycythemia rubra vera protein 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9BRJ6 | Q8N6Q3 | |
| Ensembl transtripts involved in fusion gene | ENST00000357429, ENST00000397100, ENST00000397098, ENST00000488073, | ENST00000607517, ENST00000378012, ENST00000378009, | |
| Fusion gene scores | * DoF score | 7 X 4 X 7=196 | 3 X 2 X 3=18 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/196*10)=-0.970853654340483 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: C7orf50 [Title/Abstract] AND CD177 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CD177 | GO:0030100 | regulation of endocytosis | 28807980 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRP | TCGA-B9-A44B-01A | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000357429 | ENST00000607517 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| In-frame | ENST00000357429 | ENST00000378012 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| In-frame | ENST00000357429 | ENST00000378009 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| Frame-shift | ENST00000397100 | ENST00000607517 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| Frame-shift | ENST00000397100 | ENST00000378012 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| Frame-shift | ENST00000397100 | ENST00000378009 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| Frame-shift | ENST00000397098 | ENST00000607517 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| Frame-shift | ENST00000397098 | ENST00000378012 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| Frame-shift | ENST00000397098 | ENST00000378009 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| 5UTR-3CDS | ENST00000488073 | ENST00000607517 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| 5UTR-3CDS | ENST00000488073 | ENST00000378012 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| 5UTR-3CDS | ENST00000488073 | ENST00000378009 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
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FusionProtFeatures for C7orf50_CD177 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C7orf50 | CD177 |